7TMR
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![BU of 7tmr by Molmil](/molmil-images/mine/7tmr) | V-ATPase from Saccharomyces cerevisiae, State 1 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, H(+)-transporting two-sector ATPase, V-type proton ATPase subunit C, ... | Authors: | Vasanthakumar, T, Keon, K.A, Bueler, S.A, Jaskolka, M.C, Rubinstein, J.L. | Deposit date: | 2022-01-19 | Release date: | 2022-04-13 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Coordinated conformational changes in the V 1 complex during V-ATPase reversible dissociation. Nat.Struct.Mol.Biol., 29, 2022
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7TLJ
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![BU of 7tlj by Molmil](/molmil-images/mine/7tlj) | Rhodobacter sphaeroides Mitochondrial respiratory chain complex | Descriptor: | (1R)-2-{[(R)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(DODECANOYLOXY)METHYL]ETHYL (9Z)-OCTADEC-9-ENOATE, (5S)-3-anilino-5-methyl-5-(6-phenoxypyridin-3-yl)-1,3-oxazolidine-2,4-dione, 14 kDa peptide of ubiquinol-cytochrome c2 oxidoreductase complex, ... | Authors: | Xia, D, Zhou, F, Esser, L, Huang, R. | Deposit date: | 2022-01-18 | Release date: | 2023-02-08 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | Conformation Switch of Rieske ISP subunit is revealed by the Crystal Structure of Bacterial Cytochrome bc1 in Complex with Azoxystrobin to be published
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7QUH
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![BU of 7quh by Molmil](/molmil-images/mine/7quh) | Siglec-8 in complex with therapeutic Fab AK002. | Descriptor: | Sialic acid-binding Ig-like lectin 8, Sialic acid-binding immunoglobulin-type lectin | Authors: | Lenza, M.P, Oyenarte, I, Jimenez Barbero, J, Ereno Orbea, J. | Deposit date: | 2022-01-18 | Release date: | 2023-05-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.867 Å) | Cite: | Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody. Jacs Au, 3, 2023
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7TLE
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![BU of 7tle by Molmil](/molmil-images/mine/7tle) | Crystal Structure of small molecule beta-lactone 1 covalently bound to K-Ras(G12S) | Descriptor: | (3R,4R)-1-[7-(8-chloronaphthalen-1-yl)-2-{[(2S)-1-methylpyrrolidin-2-yl]methoxy}-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl]-3-hydroxypiperidine-4-carbaldehyde, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Ziyang, Z, Guiley, K.Z, Shokat, K.M. | Deposit date: | 2022-01-18 | Release date: | 2022-08-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.98716748 Å) | Cite: | Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S). Nat.Chem.Biol., 18, 2022
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7TLK
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![BU of 7tlk by Molmil](/molmil-images/mine/7tlk) | Crystal Structure of K-Ras(G12S) | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Ziyang, Z, Guiley, K.Z, Shokat, K.M. | Deposit date: | 2022-01-18 | Release date: | 2022-08-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.71102226 Å) | Cite: | Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S). Nat.Chem.Biol., 18, 2022
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7TLG
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![BU of 7tlg by Molmil](/molmil-images/mine/7tlg) | Crystal Structure of small molecule beta-lactone 5 covalently bound to K-Ras(G12S) | Descriptor: | (3R,4R)-1-[7-(8-chloronaphthalen-1-yl)-8-fluoro-2-{[(4S,7as)-tetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy}pyrido[4,3-d]pyrimidin-4-yl]-3-hydroxypiperidine-4-carbaldehyde, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Ziyang, Z, Guiley, K.Z, Shokat, K.M. | Deposit date: | 2022-01-18 | Release date: | 2022-08-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.80000722 Å) | Cite: | Chemical acylation of an acquired serine suppresses oncogenic signaling of K-Ras(G12S). Nat.Chem.Biol., 18, 2022
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7WNL
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![BU of 7wnl by Molmil](/molmil-images/mine/7wnl) | Crystal structure of a mutant Staphylococcus equorum manganese superoxide dismutase K38R and A121Y | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AZIDE ION, BROMIDE ION, ... | Authors: | Retnoningrum, D.S, Yoshida, H, Artarini, A.A, Ismaya, W.T. | Deposit date: | 2022-01-18 | Release date: | 2023-01-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Introducing Intermolecular Interaction to Strengthen the Stability of MnSOD Dimer. Appl.Biochem.Biotechnol., 195, 2023
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7QUQ
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![BU of 7quq by Molmil](/molmil-images/mine/7quq) | BtubA(R284G,K286D,F287G):BtubB bacterial tubulin M-loop mutant forming a single protofilament (Prosthecobacter dejongeii) | Descriptor: | PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, Tubulin beta, Tubulin domain-containing protein | Authors: | Wagstaff, J, Planelles-Herrero, V.J, Derivery, E, Lowe, J. | Deposit date: | 2022-01-18 | Release date: | 2022-09-21 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics. Sci Adv, 9, 2023
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7QUP
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![BU of 7qup by Molmil](/molmil-images/mine/7qup) | D. melanogaster 13-protofilament microtubule | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wagstaff, J, Planelles-Herrero, V.J, Derivery, E, Lowe, J. | Deposit date: | 2022-01-18 | Release date: | 2022-11-02 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics. Sci Adv, 9, 2023
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7TLO
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![BU of 7tlo by Molmil](/molmil-images/mine/7tlo) | |
7WNK
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![BU of 7wnk by Molmil](/molmil-images/mine/7wnk) | Crystal structure of a mutant Staphylococcus equorum manganese superoxide dismutase K38R and A121E | Descriptor: | AZIDE ION, BROMIDE ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Retnoningrum, D.S, Yoshida, H, Artarini, A.A, Ismaya, W.T. | Deposit date: | 2022-01-18 | Release date: | 2023-01-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Introducing Intermolecular Interaction to Strengthen the Stability of MnSOD Dimer. Appl.Biochem.Biotechnol., 195, 2023
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7QTZ
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![BU of 7qtz by Molmil](/molmil-images/mine/7qtz) | Crystal structure of Iripin-1 serpin from tick Ixodes ricinus | Descriptor: | MAGNESIUM ION, Putative salivary serpin | Authors: | Kascakova, B, Kuta Smatanova, I, Chmelar, J, Prudnikova, T. | Deposit date: | 2022-01-17 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Iripin-1, a new anti-inflammatory tick serpin, inhibits leukocyte recruitment in vivo while altering the levels of chemokines and adhesion molecules. Front Immunol, 14, 2023
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7QU4
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![BU of 7qu4 by Molmil](/molmil-images/mine/7qu4) | Recombinant Human Fetal Hemoglobin mutant - alpha subunit mutations K11E,K56E,N78D,K90E | Descriptor: | Hemoglobin subunit alpha, Hemoglobin subunit gamma-2, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Kettisen, K, Nyblom, M, Bulow, L. | Deposit date: | 2022-01-17 | Release date: | 2023-01-25 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Structural and oxidative investigation of a recombinant high-yielding fetal hemoglobin mutant. Front Mol Biosci, 10, 2023
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7WN6
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![BU of 7wn6 by Molmil](/molmil-images/mine/7wn6) | Cryo-EM structure of VWF D'D3 dimer (R1136M/E1143M mutant) complexed with D1D2 at 3.29 angstron resolution (2 units) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, von Willebrand antigen 2, ... | Authors: | Zeng, J.W, Shu, Z.M, Zhou, A.W. | Deposit date: | 2022-01-17 | Release date: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Structural mechanism of VWF D'D3 dimer formation. Cell Discov, 8, 2022
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7WN4
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![BU of 7wn4 by Molmil](/molmil-images/mine/7wn4) | Cryo-EM structure of VWF D'D3 dimer (wild type) complexed with D1D2 at 3.4 angstron resolution (1 unit) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, von Willebrand antigen 2, ... | Authors: | Zeng, J.W, Shu, Z.M, Zhou, A.W. | Deposit date: | 2022-01-17 | Release date: | 2022-05-18 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural mechanism of VWF D'D3 dimer formation. Cell Discov, 8, 2022
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7WN3
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![BU of 7wn3 by Molmil](/molmil-images/mine/7wn3) | Cryo-EM structure of VWF D'D3 dimer (2M mutant) complexed with D1D2 at 3.29 angstron resolution (2 units) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, von Willebrand antigen 2, ... | Authors: | Zeng, J.W, Shu, Z.M, Zhou, A.W. | Deposit date: | 2022-01-17 | Release date: | 2022-05-25 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | Structural mechanism of VWF D'D3 dimer formation. Cell Discov, 8, 2022
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7TKT
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![BU of 7tkt by Molmil](/molmil-images/mine/7tkt) | SthK closed state, cAMP-bound in the presence of detergent | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Putative transcriptional regulator, ... | Authors: | Rheinberger, J, Schmidpeter, P.A, Nimigean, C.M. | Deposit date: | 2022-01-17 | Release date: | 2022-10-26 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Anionic lipids unlock the gates of select ion channels in the pacemaker family. Nat.Struct.Mol.Biol., 29, 2022
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7QUE
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![BU of 7que by Molmil](/molmil-images/mine/7que) | The STK17A (DRAK1) Kinase Domain Bound to CKJB68 | Descriptor: | Serine/threonine-protein kinase 17A, ~{N}-(phenylmethyl)-7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.1^{2,6}.0^{17,20}]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxamide | Authors: | Mathea, S, Preuss, F, Chatterjee, D, Dederer, V, Kurz, C.G, Amrhein, J.A, Hanke, T, Knapp, S. | Deposit date: | 2022-01-17 | Release date: | 2022-02-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5- a ]pyrimidine-Based Macrocycles. J.Med.Chem., 65, 2022
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7QUF
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![BU of 7quf by Molmil](/molmil-images/mine/7quf) | The STK17A (DRAK1) Kinase Domain Bound to CK156 | Descriptor: | Serine/threonine-protein kinase 17A, ~{N}-~{tert}-butyl-7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.1^{2,6}.0^{17,20}]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxamide | Authors: | Mathea, S, Preuss, F, Chatterjee, D, Dederer, V, Kurz, C, Hanke, T, Knapp, S. | Deposit date: | 2022-01-17 | Release date: | 2022-02-02 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5- a ]pyrimidine-Based Macrocycles. J.Med.Chem., 65, 2022
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7TKU
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![BU of 7tku by Molmil](/molmil-images/mine/7tku) | Structure of the yeast clamp loader (Replication Factor C RFC) bound to the open sliding clamp (Proliferating Cell Nuclear Antigen PCNA) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | Authors: | Gaubitz, C, Liu, X, Pajak, J, Stone, N, Hayes, J, Demo, G, Kelch, B.A. | Deposit date: | 2022-01-17 | Release date: | 2022-02-16 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-EM structures reveal high-resolution mechanism of a DNA polymerase sliding clamp loader. Elife, 11, 2022
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7QUC
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![BU of 7quc by Molmil](/molmil-images/mine/7quc) | D. melanogaster alpha/beta tubulin heterodimer in the GDP form | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wagstaff, J, Planelles-Herrero, V.J, Derivery, E, Lowe, J. | Deposit date: | 2022-01-17 | Release date: | 2022-09-21 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics. Sci Adv, 9, 2023
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7QUD
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![BU of 7qud by Molmil](/molmil-images/mine/7qud) | D. melanogaster alpha/beta tubulin heterodimer in the GTP form | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Tubulin alpha-1 chain, ... | Authors: | Wagstaff, J, Planelles-Herrero, V.J, Derivery, E, Lowe, J. | Deposit date: | 2022-01-17 | Release date: | 2022-09-21 | Last modified: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.47 Å) | Cite: | Diverse cytomotive actins and tubulins share a polymerization switch mechanism conferring robust dynamics. Sci Adv, 9, 2023
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7QR4
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![BU of 7qr4 by Molmil](/molmil-images/mine/7qr4) | human CPEB3 HDV-like ribozyme | Descriptor: | RNA CPEB3 ribozyme, U1 small nuclear ribonucleoprotein A | Authors: | Przytula-Mally, A.I, Engilberge, S, Johannsen, S, Olieric, V, Masquida, B, Sigel, R.K.O. | Deposit date: | 2022-01-17 | Release date: | 2022-10-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Anticodon-like loop-mediated dimerization in the crystal structures of HdV-like CPEB3 ribozymes Biorxiv, 2022
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7TK5
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![BU of 7tk5 by Molmil](/molmil-images/mine/7tk5) | |
7TKE
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![BU of 7tke by Molmil](/molmil-images/mine/7tke) | |