7QUF

The STK17A (DRAK1) Kinase Domain Bound to CK156

Summary for 7QUF

Entry DOI	10.2210/pdb7quf/pdb
Descriptor	Serine/threonine-protein kinase 17A, ~{N}-~{tert}-butyl-7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.1^{2,6}.0^{17,20}]docosa-1(20),2(22),3,5,14(21),15,18-heptaene-5-carboxamide (3 entities in total)
Functional Keywords	kinase inhibitor small-molecule binder macrocycle, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	63799.29
Authors	Mathea, S.,Preuss, F.,Chatterjee, D.,Dederer, V.,Kurz, C.,Hanke, T.,Knapp, S. (deposition date: 2022-01-17, release date: 2022-02-02, Last modification date: 2024-01-31)
Primary citation	Kurz, C.G.,Preuss, F.,Tjaden, A.,Cusack, M.,Amrhein, J.A.,Chatterjee, D.,Mathea, S.,Berger, L.M.,Berger, B.T.,Kramer, A.,Weller, M.,Weiss, T.,Muller, S.,Knapp, S.,Hanke, T. Illuminating the Dark: Highly Selective Inhibition of Serine/Threonine Kinase 17A with Pyrazolo[1,5- a ]pyrimidine-Based Macrocycles. J.Med.Chem., 65:7799-7817, 2022 Cited by PubMed: 35608370 DOI: 10.1021/acs.jmedchem.2c00173 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation