7WN6

Cryo-EM structure of VWF D'D3 dimer (R1136M/E1143M mutant) complexed with D1D2 at 3.29 angstron resolution (2 units)

Summary for 7WN6

• Entry DOI: 10.2210/pdb7wn6/pdb
• Related: 7WN4 7WPP 7WPQ 7WQT
• EMDB information: 32621 32622 32687 32688 32691 32692 32713
• Descriptor: von Willebrand antigen 2, von Willebrand factor, CALCIUM ION, ... (4 entities in total)
• Functional Keywords: blood, vwf, von willebrand factor, von willebrand disease, blood coagulation, blood clotting, multimer assembly, vwf assembly, d'd3 domain, d1d2 domain, d'd3 dimer, d1d2 dimer, vwf tube, repeating unit
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 547611.78

Authors

Zeng, J.W.,Shu, Z.M.,Zhou, A.W. (deposition date: 2022-01-17, release date: 2022-05-18, Last modification date: 2024-10-23)

• Primary citation: Shu, Z.,Zeng, J.,Xia, L.,Cai, H.,Zhou, A.; Structural mechanism of VWF D'D3 dimer formation.; Cell Discov, 8:14-14, 2022; PubMed: 35169124; DOI: 10.1038/s41421-022-00378-2

Experimental method

ELECTRON MICROSCOPY (3.29 Å)