8DVR
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![BU of 8dvr by Molmil](/molmil-images/mine/8dvr) | Cryo-EM structure of RIG-I bound to the end of p3SLR30 (+AMPPNP) | Descriptor: | Antiviral innate immune response receptor RIG-I, GUANOSINE-5'-TRIPHOSPHATE, ZINC ION, ... | Authors: | Wang, W, Pyle, A.M. | Deposit date: | 2022-07-29 | Release date: | 2022-11-02 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Mol.Cell, 82, 2022
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8DVS
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![BU of 8dvs by Molmil](/molmil-images/mine/8dvs) | Cryo-EM structure of RIG-I bound to the end of OHSLR30 (+ATP) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Antiviral innate immune response receptor RIG-I, MAGNESIUM ION, ... | Authors: | Wang, W, Pyle, A.M. | Deposit date: | 2022-07-29 | Release date: | 2022-11-16 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Mol.Cell, 82, 2022
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8DVU
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![BU of 8dvu by Molmil](/molmil-images/mine/8dvu) | |
7TNY
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![BU of 7tny by Molmil](/molmil-images/mine/7tny) | Cryo-EM structure of RIG-I in complex with p2dsRNA | Descriptor: | Antiviral innate immune response receptor RIG-I, ZINC ION, p2dsRNA | Authors: | Wang, W, Pyle, A.M. | Deposit date: | 2022-01-22 | Release date: | 2022-11-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Mol.Cell, 82, 2022
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7TNX
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![BU of 7tnx by Molmil](/molmil-images/mine/7tnx) | Cryo-EM structure of RIG-I in complex with p3dsRNA | Descriptor: | Antiviral innate immune response receptor RIG-I, ZINC ION, p3dsRNAa, ... | Authors: | Wang, W, Pyle, A.M. | Deposit date: | 2022-01-22 | Release date: | 2022-11-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Mol.Cell, 82, 2022
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7TO2
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7TO1
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![BU of 7to1 by Molmil](/molmil-images/mine/7to1) | Cryo-EM structure of RIG-I bound to the end of p3SLR30 (+ATP) | Descriptor: | Antiviral innate immune response receptor RIG-I, ZINC ION, p3SLR30 | Authors: | Wang, W, Pyle, A.M. | Deposit date: | 2022-01-22 | Release date: | 2022-11-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.66 Å) | Cite: | The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Mol.Cell, 82, 2022
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7TO0
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![BU of 7to0 by Molmil](/molmil-images/mine/7to0) | Cryo-EM structure of RIG-I in complex with OHdsRNA | Descriptor: | Antiviral innate immune response receptor RIG-I, OHdsRNA, ZINC ION | Authors: | Wang, W, Pyle, A.M. | Deposit date: | 2022-01-22 | Release date: | 2022-11-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Mol.Cell, 82, 2022
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7TNZ
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![BU of 7tnz by Molmil](/molmil-images/mine/7tnz) | Cryo-EM structure of RIG-I in complex with p1dsRNA | Descriptor: | Antiviral innate immune response receptor RIG-I, ZINC ION, p1dsRNA | Authors: | Wang, W, Pyle, A.M. | Deposit date: | 2022-01-22 | Release date: | 2022-11-02 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | The RIG-I receptor adopts two different conformations for distinguishing host from viral RNA ligands. Mol.Cell, 82, 2022
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7PNE
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![BU of 7pne by Molmil](/molmil-images/mine/7pne) | |
7PNG
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![BU of 7png by Molmil](/molmil-images/mine/7png) | |
8S86
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![BU of 8s86 by Molmil](/molmil-images/mine/8s86) | human PLD3 homodimer structure | Descriptor: | 5'-3' exonuclease PLD3 | Authors: | Lammens, K. | Deposit date: | 2024-03-05 | Release date: | 2024-05-15 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Lysosomal endonuclease RNase T2 and PLD exonucleases cooperatively generate RNA ligands for TLR7 activation. Immunity, 57, 2024
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6YX2
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![BU of 6yx2 by Molmil](/molmil-images/mine/6yx2) | Crystal structure of SHANK1 PDZ in complex with a peptide-small molecule hybrid | Descriptor: | 4-[[(~{E})-5-oxidanylidenepentanoyldiazenyl]methyl]benzoic acid, PWW-THR-ARG-LEU, SH3 and multiple ankyrin repeat domains protein 1 | Authors: | Hegedus, Z, Hobor, F, Shoemark, D.K, Celis, S, Lian, L.J, Trinh, C.H, Sessions, R.B, Edwards, T.A, Wilson, A.J. | Deposit date: | 2020-04-30 | Release date: | 2021-01-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Identification of beta-strand mediated protein-protein interaction inhibitors using ligand-directed fragment ligation. Chem Sci, 12, 2021
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6YX0
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![BU of 6yx0 by Molmil](/molmil-images/mine/6yx0) | Crystal structure of SHANK1 PDZ in complex with a peptide-small molecule hybrid | Descriptor: | 4-[[2-(4-oxidanylidenebutanoyl)hydrazinyl]methyl]benzoic acid, PWQ-THR-ARG-LEU, SH3 and multiple ankyrin repeat domains protein 1 | Authors: | Hegedus, Z, Hobor, F, Shoemark, D.K, Celis, S, Trinh, C.H, Sessions, R.B, Edwards, T.A, Wilson, A.J. | Deposit date: | 2020-04-30 | Release date: | 2021-01-20 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.57 Å) | Cite: | Identification of beta-strand mediated protein-protein interaction inhibitors using ligand-directed fragment ligation. Chem Sci, 12, 2021
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1Z1M
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![BU of 1z1m by Molmil](/molmil-images/mine/1z1m) | NMR structure of unliganded MDM2 | Descriptor: | Ubiquitin-protein ligase E3 Mdm2 | Authors: | Uhrinova, S, Uhrin, D, Powers, H, Watt, K, Zheleva, D, Fischer, P, McInnes, C, Barlow, P.N. | Deposit date: | 2005-03-04 | Release date: | 2005-06-28 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Structure of Free MDM2 N-terminal Domain Reveals Conformational Adjustments that Accompany p53-binding J.Mol.Biol., 350, 2005
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2O58
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![BU of 2o58 by Molmil](/molmil-images/mine/2o58) | Horse heart met manganese myoglobin | Descriptor: | Myoglobin, PROTOPORPHYRIN IX CONTAINING MN, SULFATE ION | Authors: | Richter-Addo, G.B, Zahran, Z.N, Chooback, L, Copeland, D.M, West, A.H. | Deposit date: | 2006-12-05 | Release date: | 2007-10-16 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal structures of manganese- and cobalt-substituted myoglobin in complex with NO and nitrite reveal unusual ligand conformations. J.Inorg.Biochem., 102, 2008
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2O5B
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![BU of 2o5b by Molmil](/molmil-images/mine/2o5b) | Manganese horse heart myoglobin, reduced | Descriptor: | MANGANESE PROTOPORPHYRIN IX, Myoglobin, SULFATE ION | Authors: | Richter-Addo, G.B, Zahran, Z.N, Chooback, L, Copeland, D.M, West, A.H. | Deposit date: | 2006-12-05 | Release date: | 2007-10-16 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structures of manganese- and cobalt-substituted myoglobin in complex with NO and nitrite reveal unusual ligand conformations. J.Inorg.Biochem., 102, 2008
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3JZC
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![BU of 3jzc by Molmil](/molmil-images/mine/3jzc) | Crystal Structure of TR-beta bound to the selective thyromimetic TRIAC | Descriptor: | Thyroid hormone receptor beta, [4-(4-HYDROXY-3-IODO-PHENOXY)-3,5-DIIODO-PHENYL]-ACETIC ACID | Authors: | Nascimento, A.S, Dias, S.G.M, Nunes, F.M, Aparicio, R. | Deposit date: | 2009-09-23 | Release date: | 2009-12-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Gaining ligand selectivity in thyroid hormone receptors via entropy. Proc.Natl.Acad.Sci.USA, 106, 2009
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4WCC
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![BU of 4wcc by Molmil](/molmil-images/mine/4wcc) | Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, with mutation P225G | Descriptor: | 2',3'-cyclic-nucleotide 3'-phosphodiesterase, ADENOSINE-2'-MONOPHOSPHATE, CHLORIDE ION | Authors: | Myllykoski, M, Raasakka, A, Kursula, P. | Deposit date: | 2014-09-04 | Release date: | 2015-09-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Determinants of ligand binding and catalytic activity in the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase. Sci Rep, 5, 2015
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4WDB
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![BU of 4wdb by Molmil](/molmil-images/mine/4wdb) | Catalytic domain of mouse 2',3'-cyclic nucleotide 3'- phosphodiesterase, with mutation R307Q, complexed with 2'-AMP | Descriptor: | 2',3'-cyclic-nucleotide 3'-phosphodiesterase, ADENOSINE-2'-MONOPHOSPHATE, CHLORIDE ION | Authors: | Myllykoski, M, Raasakka, A, Kursula, P. | Deposit date: | 2014-09-08 | Release date: | 2015-09-23 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Determinants of ligand binding and catalytic activity in the myelin enzyme 2',3'-cyclic nucleotide 3'-phosphodiesterase. Sci Rep, 5, 2015
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4V0I
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![BU of 4v0i by Molmil](/molmil-images/mine/4v0i) | Water Network Determines Selectivity for a Series of Pyrimidone Indoline Amide PI3KBeta Inhibitors over PI3K-Delta | Descriptor: | 2-[2-(2-METHYL-2,3-DIHYDRO-INDOL-1-YL)-2-OXO-ETHYL]-6-MORPHOLIN-4-YL-3H-PYRIMIDIN-4-ONE, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT DELTA ISOFORM | Authors: | Robinson, D, Bertrand, T, Carry, J.C, Halley, F, Karlsson, A, Mathieu, M, Minoux, H, Perrin, M.A, Robert, B, Schio, L, Sherman, W. | Deposit date: | 2014-09-16 | Release date: | 2015-09-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Differential Water Thermodynamics Determine Pi3K-Beta/Delta Selectivity for Solvent-Exposed Ligand Modifications. J.Chem.Inf.Model., 56, 2016
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8PPE
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![BU of 8ppe by Molmil](/molmil-images/mine/8ppe) | Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with DL-6-deoxy-6-phosphoryloxymethyl-scyllo-inositol 1,2,4-trisphosphate/ADP/Mn | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, DL-6-deoxy-6-phosphoryloxymethyl-scyllo-inositol 1,2,4-trisphosphate, GLYCEROL, ... | Authors: | Marquez-Monino, M.A, Gonzalez, B. | Deposit date: | 2023-07-07 | Release date: | 2024-02-28 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity. Nat Commun, 15, 2024
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8PPB
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![BU of 8ppb by Molmil](/molmil-images/mine/8ppb) | Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with D-3-deoxy-myo-inositol 1,4,6-trisphosphate/ATP/Mn | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, D-3-deoxy-myo-inositol 1,4,6-trisphosphate, Inositol-trisphosphate 3-kinase A, ... | Authors: | Marquez-Monino, M.A, Gonzalez, B. | Deposit date: | 2023-07-07 | Release date: | 2024-02-28 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity. Nat Commun, 15, 2024
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8PPC
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![BU of 8ppc by Molmil](/molmil-images/mine/8ppc) | Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with L-chiro-inositol 2,3,5-trisphosphate/ATP/Mn | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Inositol-trisphosphate 3-kinase A, L-chiro-inositol 2,3,5-trisphosphate, ... | Authors: | Marquez-Monino, M.A, Gonzalez, B. | Deposit date: | 2023-07-07 | Release date: | 2024-02-28 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.92 Å) | Cite: | Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity. Nat Commun, 15, 2024
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8PP9
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![BU of 8pp9 by Molmil](/molmil-images/mine/8pp9) | Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with scyllo-inositol 1,2,3,5-tetrakisphosphate/ADP/Mn | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Inositol-trisphosphate 3-kinase A, MANGANESE (II) ION, ... | Authors: | Marquez-Monino, M.A, Gonzalez, B. | Deposit date: | 2023-07-07 | Release date: | 2024-02-28 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity. Nat Commun, 15, 2024
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