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5CA2	CONFORMATIONAL MOBILITY OF HIS-64 IN THE THR-200 (RIGHT ARROW) SER MUTANT OF HUMAN CARBONIC ANHYDRASE II Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, ZINC ION Authors: Alexander, R.S, Christianson, D.W. Deposit date: 1991-06-08 Release date: 1992-10-31 Last modified: 2024-03-06 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Conformational mobility of His-64 in the Thr-200----Ser mutant of human carbonic anhydrase II. Biochemistry, 30, 1991
4LU3	The crystal structure of the human carbonic anhydrase XIV Descriptor: 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase 14, GLYCEROL, ... Authors: Alterio, V, De Simone, G, Monti, S.M. Deposit date: 2013-07-24 Release date: 2014-01-01 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2 Å) Cite: The structural comparison between membrane-associated human carbonic anhydrases provides insights into drug design of selective inhibitors. Biopolymers, 101, 2014
4QEF	Human Carbonic Anhydrase II V207I - cyanate inhibitor complex Descriptor: Carbonic anhydrase 2, GLYCEROL, ZINC ION, ... Authors: West, D.M. Deposit date: 2014-05-15 Release date: 2014-10-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.469 Å) Cite: Human carbonic anhydrase II-cyanate inhibitor complex: putting the debate to rest. Acta Crystallogr F Struct Biol Commun, 70, 2014
3LXE	Human Carbonic Anhydrase I in complex with topiramate Descriptor: Carbonic anhydrase 1, ZINC ION, [(3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d]pyran-3a-yl]methyl sulfamate Authors: Alterio, V, De Simone, G, Monti, S.M, Truppo, E. Deposit date: 2010-02-25 Release date: 2010-07-21 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The first example of a significant active site conformational rearrangement in a carbonic anhydrase-inhibitor adduct: the carbonic anhydrase I-topiramate complex. Org.Biomol.Chem., 2010
3S78	The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase Descriptor: Carbonic anhydrase 2, ZINC ION, thiophene-2-sulfonamide Authors: Snyder, P.W, Heroux, A, Whitesides, G.W. Deposit date: 2011-05-26 Release date: 2011-10-19 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase. Proc.Natl.Acad.Sci.USA, 108, 2011
3S75	The origin of the hydrophobic effect in the molecular recognition of arylsulfonamides by carbonic anhydrase Descriptor: Carbonic anhydrase 2, ZINC ION, furan-2-sulfonamide Authors: Snyder, P.W, Heroux, A, Whitesides, G.W. Deposit date: 2011-05-26 Release date: 2011-10-19 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Mechanism of the hydrophobic effect in the biomolecular recognition of arylsulfonamides by carbonic anhydrase. Proc.Natl.Acad.Sci.USA, 108, 2011
3MNJ	Human Carbonic Anhydrase II Mutant K170E Descriptor: Carbonic anhydrase 2, SODIUM ION, ZINC ION Authors: Domsic, J.F, McKenna, R. Deposit date: 2010-04-21 Release date: 2010-07-14 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II. Biochemistry, 49, 2010
1RJ6	Crystal Structure of the Extracellular Domain of Murine Carbonic Anhydrase XIV in Complex with Acetazolamide Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-ACETAMIDO-1,3,4-THIADIAZOLE-2-SULFONAMIDE, Carbonic anhydrase XIV, ... Authors: Whittington, D.A, Grubb, J.H, Waheed, A, Shah, G.N, Sly, W.S, Christianson, D.W. Deposit date: 2003-11-18 Release date: 2004-03-09 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Expression, assay, and structure of the extracellular domain of murine carbonic anhydrase XIV: implications for selective inhibition of membrane-associated isozymes. J.Biol.Chem., 279, 2004
3MNH	Human Carbonic Anhydrase II Mutant K170A Descriptor: Carbonic anhydrase 2, SODIUM ION, ZINC ION Authors: Domsic, J.F, McKenna, R. Deposit date: 2010-04-21 Release date: 2010-07-14 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II. Biochemistry, 49, 2010
3MNI	Human Carbonic Anhydrase II Mutant K170D Descriptor: Carbonic anhydrase 2, SODIUM ION, ZINC ION Authors: Domsic, J.F, McKenna, R. Deposit date: 2010-04-21 Release date: 2010-07-14 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Structural and kinetic study of the extended active site for proton transfer in human carbonic anhydrase II. Biochemistry, 49, 2010
3TMJ	Joint X-ray/neutron structure of human carbonic anhydrase II at pH 7.8 Descriptor: Carbonic anhydrase 2, ZINC ION Authors: Fisher, Z. Deposit date: 2011-08-31 Release date: 2011-11-09 Last modified: 2023-09-13 Method: NEUTRON DIFFRACTION (2 Å), X-RAY DIFFRACTION Cite: Neutron Structure of Human Carbonic Anhydrase II: A Hydrogen-Bonded Water Network "Switch" Is Observed between pH 7.8 and 10.0. Biochemistry, 50, 2011
3RLD	Crystal structure of the Y7I mutant of human carbonic anhydrase II Descriptor: Carbonic anhydrase 2, SULFATE ION, ZINC ION Authors: Avvaru, B.S, Mikulski, R, McKenna, R. Deposit date: 2011-04-19 Release date: 2012-02-08 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Kinetic and crystallographic studies of the role of tyrosine 7 in the active site of human carbonic anhydrase II. Arch.Biochem.Biophys., 506, 2011
3P5A	Human Carbonic Anhydrase complexed with Sodium morpholinocarbodithioate Descriptor: Carbonic anhydrase 2, DIMETHYL SULFOXIDE, ZINC ION, ... Authors: Aggarwal, M, McKenna, R. Deposit date: 2010-10-08 Release date: 2011-10-19 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo J.Med.Chem., 55, 2012
3P58	Human Carbonic Anhydrase in complex with Benzyl (Methyl) Carbamodithoic Acid Descriptor: Carbonic anhydrase 2, ZINC ION, benzyl(methyl)carbamodithioic acid Authors: Aggarwal, M, McKenna, R. Deposit date: 2010-10-08 Release date: 2011-10-19 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Dithiocarbamates: a new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations. Chem.Commun.(Camb.), 48, 2012
3M5S	Carbonic Anhydrase II mutant H64C in complex with carbonate Descriptor: CARBONATE ION, Carbonic anhydrase 2, ZINC ION Authors: Schulze Wischeler, J, Heine, A, Klebe, G. Deposit date: 2010-03-13 Release date: 2011-05-25 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Mutational study on Carbonic Anhydrase II TO BE PUBLISHED
4O1J	Crystal structures of two tetrameric beta-carbonic anhydrases from the filamentous ascomycete Sordaria macrospora. Descriptor: CHLORIDE ION, Carbonic anhydrase, ZINC ION Authors: Lehneck, R, Neumann, P, Vullo, D, Elleuche, S, Supuran, C.T, Ficner, R, Poggeler, S. Deposit date: 2013-12-16 Release date: 2014-03-05 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (2.695 Å) Cite: Crystal structures of two tetrameric beta-carbonic anhydrases from the filamentous ascomycete Sordaria macrospora. Febs J., 281, 2014
3MWO	Human carbonic anhydrase II in a doubled monoclinic cell: a re-determination Descriptor: Carbonic anhydrase 2, ZINC ION Authors: Robbins, A.H, McKenna, R. Deposit date: 2010-05-06 Release date: 2010-06-09 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Emerging from pseudo-symmetry: the redetermination of human carbonic anhydrase II in monoclinic P2(1) with a doubled a axis. Acta Crystallogr.,Sect.D, 66, 2010
3M1K	Carbonic Anhydrase in complex with fragment Descriptor: (4-CARBOXYPHENYL)(CHLORO)MERCURY, 1-hydroxy-2-sulfanylpyridinium, Carbonic anhydrase 2, ... Authors: Schulze Wischeler, J, Heine, A, Klebe, G. Deposit date: 2010-03-05 Release date: 2010-11-17 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.35 Å) Cite: Bidentate Zinc chelators for alpha-carbonic anhydrases that produce a trigonal bipyramidal coordination geometry. Chemmedchem, 5, 2010
3MNA	The crystal structure of human carbonic anhydrase Ii in complex with a 1,3,5-triazine-substituted benzenesulfonamide inhibitor Descriptor: Carbonic anhydrase 2, GLYCEROL, ZINC ION, ... Authors: Avvaru, B.S, Wagner, J, Robbins, A.H, Mckenna, R. Deposit date: 2010-04-21 Release date: 2011-04-20 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Sulfonamides incorporating 1,3,5-triazine moieties selectively and potently inhibit carbonic anhydrase transmembrane isoforms IX, XII and XIV over cytosolic isoforms I and II: Solution and X-ray crystallographic studies. Bioorg.Med.Chem., 19, 2011
1CA2	REFINED STRUCTURE OF HUMAN CARBONIC ANHYDRASE II AT 2.0 ANGSTROMS RESOLUTION Descriptor: CARBONIC ANHYDRASE II, ZINC ION Authors: Eriksson, A.E, Jones, T.A, Liljas, A. Deposit date: 1989-02-06 Release date: 1990-01-15 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Refined structure of human carbonic anhydrase II at 2.0 A resolution. Proteins, 4, 1988
1BCD	X-RAY CRYSTALLOGRAPHIC STRUCTURE OF A COMPLEX BETWEEN HUMAN CARBONIC ANHYDRASE II AND A NEW TOPICAL INHIBITOR, TRIFLUOROMETHANE SULPHONAMIDE Descriptor: CARBONIC ANHYDRASE II, TRIFLUOROMETHANE SULFONAMIDE, ZINC ION Authors: Hakansson, K, Liljas, A. Deposit date: 1993-08-31 Release date: 1993-10-31 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: The structure of a complex between carbonic anhydrase II and a new inhibitor, trifluoromethane sulphonamide. FEBS Lett., 350, 1994
1BZM	DRUG-PROTEIN INTERACTIONS: STRUCTURE OF SULFONAMIDE DRUG COMPLEXED WITH HUMAN CARBONIC ANHYDRASE I Descriptor: CARBONIC ANHYDRASE I, N-(3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene)acetamide, ZINC ION Authors: Chakravarty, S, Kannan, K.K. Deposit date: 1993-11-28 Release date: 1994-04-30 Last modified: 2024-02-07 Method: X-RAY DIFFRACTION (2 Å) Cite: Drug-protein interactions. Refined structures of three sulfonamide drug complexes of human carbonic anhydrase I enzyme. J.Mol.Biol., 243, 1994
1CAN	CRYSTALLOGRAPHIC STUDIES OF THE BINDING OF PROTONATED AND UNPROTONATED INHIBITORS TO CARBONIC ANHYDRASE USING HYDROGEN SULPHIDE AND NITRATE ANIONS Descriptor: CARBONIC ANHYDRASE II, MERCURY (II) ION, NITRATE ION Authors: Mangani, S, Hakansson, K. Deposit date: 1992-07-02 Release date: 1994-01-31 Last modified: 2017-11-29 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystallographic studies of the binding of protonated and unprotonated inhibitors to carbonic anhydrase using hydrogen sulphide and nitrate anions. Eur.J.Biochem., 210, 1992
1A42	HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH BRINZOLAMIDE Descriptor: (4R)-2-(2-ethoxyethyl)-4-(ethylamino)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide, CARBONIC ANHYDRASE II, MERCURY (II) ION, ... Authors: Boriack-Sjodin, P.A, Christianson, D.W. Deposit date: 1998-02-10 Release date: 1999-03-23 Last modified: 2024-04-03 Method: X-RAY DIFFRACTION (2.25 Å) Cite: Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination. Protein Sci., 7, 1998
1EOU	CRYSTAL STRUCTURE OF HUMAN CARBONIC ANHYDRASE II COMPLEXED WITH AN ANTICONVULSANT SUGAR SULFAMATE Descriptor: CARBONIC ANHYDRASE II (CA II), SULFAMIC ACID 2,3-O-(1-METHYLETHYLIDENE)-4,5-O-SULFONYL-BETA-FRUCTOPYRANOSE ESTER, ZINC ION Authors: Recacha, R, Costanzo, M.J, Maryanoff, B.E, Chattopadhyay, D. Deposit date: 2000-03-24 Release date: 2002-02-13 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structure of human carbonic anhydrase II complexed with an anti-convulsant sugar sulphamate. Biochem.J., 361, 2002

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