6SDT
HUMAN CARBONIC ANHYDRASE VII IN COMPLEX WITH A SULFONAMIDE INHIBITOR
Summary for 6SDT
Entry DOI | 10.2210/pdb6sdt/pdb |
Descriptor | Carbonic anhydrase 7, ZINC ION, phenyl-(4-sulfamoylphenoxy)phosphinic acid, ... (4 entities in total) |
Functional Keywords | carbonic anhydrase vii, zinc enzyme, inhibitor, sulfonamide, lyase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 31304.37 |
Authors | Alterio, V.,De Simone, G.,Esposito, D. (deposition date: 2019-07-29, release date: 2020-06-10, Last modification date: 2024-01-24) |
Primary citation | Nocentini, A.,Alterio, V.,Bua, S.,Micheli, L.,Esposito, D.,Buonanno, M.,Bartolucci, G.,Osman, S.M.,ALOthman, Z.A.,Cirilli, R.,Pierini, M.,Monti, S.M.,Di Cesare Mannelli, L.,Gratteri, P.,Ghelardini, C.,De Simone, G.,Supuran, C.T. Phenyl(thio)phosphon(amid)ate Benzenesulfonamides as Potent and Selective Inhibitors of Human Carbonic Anhydrases II and VII Counteract Allodynia in a Mouse Model of Oxaliplatin-Induced Neuropathy. J.Med.Chem., 63:5185-5200, 2020 Cited by PubMed: 32364386DOI: 10.1021/acs.jmedchem.9b02135 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.94 Å) |
Structure validation
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