PDB: 4955 resultsInfo pagesStatus searchChemie searchBIRD

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4KRD	Crystal Structure of Pho85-Pcl10 Complex Descriptor: Cyclin-dependent protein kinase PHO85, PHO85 cyclin-10 Authors: Quiocho, F.A, Zheng, F. Deposit date: 2013-05-16 Release date: 2013-09-18 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (1.952 Å) Cite: New Structural Insights into Phosphorylation-free Mechanism for Full Cyclin-dependent Kinase (CDK)-Cyclin Activity and Substrate Recognition. J.Biol.Chem., 288, 2013
4LQS	Crystal structure of the Cbk1-Mob2 kinase-coactivator complex Descriptor: CBK1 kinase activator protein MOB2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase CBK1 Authors: Gogl, G, Remenyi, A. Deposit date: 2013-07-19 Release date: 2014-07-30 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (3.3 Å) Cite: The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism. Plos Biol., 13, 2015
4M97	Calcium-Dependent Protein Kinase 1 from Neospora caninum Descriptor: Calmodulin-like domain protein kinase isoenzyme gamma, related Authors: Merritt, E.A. Deposit date: 2013-08-14 Release date: 2013-10-02 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.05 Å) Cite: Neospora caninum Calcium-Dependent Protein Kinase 1 Is an Effective Drug Target for Neosporosis Therapy. Plos One, 9, 2014
4LQP	Crystal structure of the Cbk1(T743E)-Mob2 kinase-coactivator complex, in crystal form A Descriptor: CBK1 kinase activator protein MOB2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase CBK1 Authors: Gogl, G, Remenyi, A. Deposit date: 2013-07-19 Release date: 2014-07-30 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (4.5 Å) Cite: The Structure of an NDR/LATS Kinase-Mob Complex Reveals a Novel Kinase-Coactivator System and Substrate Docking Mechanism. Plos Biol., 13, 2015
3TNI	structure of CDK9/cyclin T F241L Descriptor: Cyclin-T1, Cyclin-dependent kinase 9 Authors: Baumli, S, Hole, A.J, Endicott, J.A. Deposit date: 2011-09-01 Release date: 2012-02-15 Last modified: 2012-05-30 Method: X-RAY DIFFRACTION (3.234 Å) Cite: The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508. Acs Chem.Biol., 7, 2012
3TNH	CDK9/cyclin T in complex with CAN508 Descriptor: 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, Cyclin-T1, Cyclin-dependent kinase 9 Authors: Baumli, S, Hole, A.J, Endicott, J.A. Deposit date: 2011-09-01 Release date: 2012-02-15 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.202 Å) Cite: The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508. Acs Chem.Biol., 7, 2012
3SOA	Full-length human CaMKII Descriptor: 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile, Calcium/calmodulin-dependent protein kinase type II subunit alpha with a beta 7 linker Authors: Chao, L.H, Kuriyan, J. Deposit date: 2011-06-30 Release date: 2011-08-31 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.5501 Å) Cite: A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca(2+)/Calmodulin- Dependent Kinase II Holoenzyme. Cell(Cambridge,Mass.), 146, 2011
3SX9	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-132 Descriptor: 3-(6-ethoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1 Authors: Larson, E.T, Merritt, E.A. Deposit date: 2011-07-14 Release date: 2012-03-14 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.65 Å) Cite: Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J.Med.Chem., 55, 2012
3SXF	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-89 Descriptor: 1,2-ETHANEDIOL, 3-(6-ethoxynaphthalen-2-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1, ... Authors: Larson, E.T, Merritt, E.A. Deposit date: 2011-07-14 Release date: 2012-03-14 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J.Med.Chem., 55, 2012
3T3U	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-130 Descriptor: 1,2-ETHANEDIOL, 3-(6-methoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1, ... Authors: Larson, E.T, Merritt, E.A. Deposit date: 2011-07-25 Release date: 2012-03-14 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J.Med.Chem., 55, 2012
3SDM	Structure of oligomeric kinase/RNase Ire1 in complex with an oligonucleotide Descriptor: Serine/threonine-protein kinase/endoribonuclease IRE1 Authors: Korennykh, A, Korostelev, A, Egea, P, Finer-Moore, J, Zhang, C, Stroud, R, Shokat, K, Walter, P. Deposit date: 2011-06-09 Release date: 2011-07-13 Method: X-RAY DIFFRACTION (6.6 Å) Cite: Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1. Bmc Biol., 9, 2011
3TG1	Crystal structure of p38alpha in complex with a MAPK docking partner Descriptor: Dual specificity protein phosphatase 10, Mitogen-activated protein kinase 14 Authors: Zhang, Y.Y, Wu, J.W, Wang, Z.X. Deposit date: 2011-08-17 Release date: 2012-03-14 Last modified: 2023-11-01 Method: X-RAY DIFFRACTION (2.71 Å) Cite: A Distinct Interaction Mode Revealed by the Crystal Structure of the Kinase p38alpha with the MAPK Binding Domain of the Phosphatase MKP5. Sci.Signal., 4, 2011
3T8O	Rhodopsin kinase (GRK1) L166K mutant at 2.5A resolution Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, GLYCEROL, ... Authors: Tesmer, J.J.G, Singh, P, Nance, M.R. Deposit date: 2011-08-01 Release date: 2012-06-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure of a monomeric variant of rhodopsin kinase at 2.5 A resolution. Acta Crystallogr.,Sect.F, 68, 2012
3T3V	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with Bumped Kinase Inhibitor, RM-1-87 Descriptor: 1,2-ETHANEDIOL, 3-(6-methoxynaphthalen-2-yl)-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1 Authors: Larson, E.T, Merritt, E.A. Deposit date: 2011-07-25 Release date: 2012-03-14 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.04 Å) Cite: Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J.Med.Chem., 55, 2012
3TAC	Crystal Structure of the Liprin-alpha/CASK complex Descriptor: CHLORIDE ION, Liprin-alpha-2, Peripheral plasma membrane protein CASK, ... Authors: Wei, Z, Zheng, S, Yu, C, Zhang, M. Deposit date: 2011-08-03 Release date: 2011-10-12 Last modified: 2024-03-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Liprin-mediated large signaling complex organization revealed by the liprin-alpha/CASK and liprin-alpha/liprin-beta complex structures Mol.Cell, 43, 2011
3TNW	Structure of CDK2/cyclin A in complex with CAN508 Descriptor: 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, Cyclin-A2, Cyclin-dependent kinase 2, ... Authors: Baumli, S, Hole, A.J, Endicott, J.A. Deposit date: 2011-09-02 Release date: 2012-02-15 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2 Å) Cite: The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508. Acs Chem.Biol., 7, 2012
3V5T	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1299 Descriptor: 1-[(2S)-2-(dimethylamino)-3-methylbutyl]-3-(6-ethoxynaphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1 Authors: Merritt, E.A, Larson, E.T. Deposit date: 2011-12-16 Release date: 2012-03-14 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.13 Å) Cite: Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012
3UZT	Structure of the C13.18 RNA Aptamer in Complex with G Protein-Coupled Receptor Kinase 2 Descriptor: Beta-adrenergic receptor kinase 1, C13.18 RNA Aptamer, MAGNESIUM ION Authors: Tesmer, J.J.G, Tesmer, V.M. Deposit date: 2011-12-07 Release date: 2012-07-11 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (3.51 Å) Cite: Molecular mechanism for inhibition of g protein-coupled receptor kinase 2 by a selective RNA aptamer. Structure, 20, 2012
3V51	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor RM-1-176 Descriptor: 3-{6-[(3-chlorobenzyl)oxy]naphthalen-2-yl}-1-(propan-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1 Authors: Merritt, E.A, Larson, E.T. Deposit date: 2011-12-15 Release date: 2012-03-14 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012
3V5P	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1288 Descriptor: 3-(4-methoxy-3-methylphenyl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1 Authors: Merritt, E.A, Larson, E.T. Deposit date: 2011-12-16 Release date: 2012-03-14 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012
3UPX	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1300 Descriptor: Calmodulin-domain protein kinase 1, [2-amino-1-(piperidin-4-ylmethyl)-1H-benzimidazol-6-yl](phenyl)methanone Authors: Merritt, E.A, Larson, E.T. Deposit date: 2011-11-18 Release date: 2012-03-14 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.27 Å) Cite: Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012
3UPZ	Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with bumpless BKI analog UW1243 Descriptor: 1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, Calmodulin-domain protein kinase 1 Authors: Merritt, E.A, Larson, E.T. Deposit date: 2011-11-18 Release date: 2012-03-14 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Multiple Determinants for Selective Inhibition of Apicomplexan Calcium-Dependent Protein Kinase CDPK1. J.Med.Chem., 55, 2012
3V5W	Human G Protein-Coupled Receptor Kinase 2 in Complex with Soluble Gbetagamma Subunits and Paroxetine Descriptor: G-protein coupled receptor kinase 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... Authors: Thal, D.M, Tesmer, J.J.G. Deposit date: 2011-12-17 Release date: 2012-09-26 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.07 Å) Cite: Paroxetine is a direct inhibitor of g protein-coupled receptor kinase 2 and increases myocardial contractility. Acs Chem.Biol., 7, 2012
3UJG	Crystal structure of SnRK2.6 in complex with HAB1 Descriptor: MAGNESIUM ION, Protein phosphatase 2C 16, SULFATE ION, ... Authors: Zhou, X.E, Soon, F.-F, Ng, L.-M, Kovach, A, Tan, M.H.E, Suino-Powell, K.M, He, Y, Xu, Y, Brunzelle, J.S, Li, J, Melcher, K, Xu, H.E. Deposit date: 2011-11-07 Release date: 2012-02-15 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Molecular mimicry regulates ABA signaling by SnRK2 kinases and PP2C phosphatases. Science, 335, 2012
3TN8	CDK9/cyclin T in complex with CAN508 Descriptor: 4-[(E)-(3,5-DIAMINO-1H-PYRAZOL-4-YL)DIAZENYL]PHENOL, Cyclin-T1, Cyclin-dependent kinase 9, ... Authors: Baumli, S, Hole, A.J, Endicott, J.E. Deposit date: 2011-09-01 Release date: 2012-02-15 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.95 Å) Cite: The CDK9 C-helix Exhibits Conformational Plasticity That May Explain the Selectivity of CAN508. Acs Chem.Biol., 7, 2012

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