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7SL7	Full-length insulin receptor bound with both site 1 binding deficient mutant insulin (A-V3E) and site 2 binding deficient mutant insulin (A-L13R) Descriptor: Insulin A chain (L13R), Insulin A chain (V3E), Insulin B chain, ... Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL1	Full-length insulin receptor bound with site 1 binding deficient mutant insulin (A-V3E) Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL4	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- asymmetric conformation Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (5 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL3	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (A-L13R) -- symmetric conformation Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL2	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (A-L13R) -- asymmetric conformation Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.6 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7SL6	Full-length insulin receptor bound with site 2 binding deficient mutant insulin (B-L17R) -- symmetric conformation Descriptor: Insulin A chain, Insulin B chain, Insulin receptor Authors: Bai, X.C, Choi, E. Deposit date: 2021-10-22 Release date: 2022-03-30 Last modified: 2022-04-27 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: Synergistic activation of the insulin receptor via two distinct sites. Nat.Struct.Mol.Biol., 29, 2022
7S0Q	Head region of a complex of IGF-I with the ectodomain of a hybrid insulin receptor / type 1 insulin-like growth factor receptor Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor, ... Authors: Xu, Y, Lawrence, M.C. Deposit date: 2021-08-30 Release date: 2022-07-06 Last modified: 2022-08-17 Method: ELECTRON MICROSCOPY (3.7 Å) Cite: How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor. Structure, 30, 2022
6PXV	Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the extracellular region. Descriptor: Insulin, Insulin receptor Authors: Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C. Deposit date: 2019-07-27 Release date: 2019-09-04 Method: ELECTRON MICROSCOPY (3.2 Å) Cite: Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. Elife, 8, 2019
6PYH	Cryo-EM structure of full-length IGF1R-IGF1 complex. Only the extracellular region of the complex is resolved. Descriptor: Insulin-like growth factor 1 receptor, Insulin-like growth factor I Authors: Li, J, Choi, E, Yu, H.T, Bai, X.C. Deposit date: 2019-07-29 Release date: 2019-10-23 Method: ELECTRON MICROSCOPY (4.3 Å) Cite: Structural basis of the activation of type 1 insulin-like growth factor receptor. Nat Commun, 10, 2019
6PXW	Cryo-EM structure of full-length insulin receptor bound to 4 insulin. 3D refinement was focused on the top part of the receptor complex. Descriptor: Insulin, Insulin receptor Authors: Uchikawa, E, Choi, E, Shang, G.J, Yu, H.T, Bai, X.C. Deposit date: 2019-07-28 Release date: 2019-09-04 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Activation mechanism of the insulin receptor revealed by cryo-EM structure of the fully liganded receptor-ligand complex. Elife, 8, 2019
2V5P	COMPLEX STRUCTURE OF HUMAN IGF2R DOMAINS 11-13 BOUND TO IGF-II Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR, INSULIN-LIKE GROWTH FACTOR II, ... Authors: Brown, J, Delaine, C, Zaccheo, O.J, Siebold, C, Gilbert, R.J, van Boxel, G, Denley, A, Wallace, J.C, Hassan, A.B, Forbes, B.E, Jones, E.Y. Deposit date: 2007-07-06 Release date: 2007-12-11 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (4.1 Å) Cite: Structure and Functional Analysis of the Igf-II/Igf2R Interaction Embo J., 27, 2008
5U8Q	Structure of the ectodomain of the human Type 1 insulin-like growth factor receptor in complex with IGF-I Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-MALATE, ... Authors: Lawrence, M, Xu, Y. Deposit date: 2016-12-14 Release date: 2018-02-28 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (3.2710402 Å) Cite: How ligand binds to the type 1 insulin-like growth factor receptor. Nat Commun, 9, 2018

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