5W4K
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![BU of 5w4k by Molmil](/molmil-images/mine/5w4k) | Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution | Descriptor: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ... | Authors: | Metelev, M, Osterman, I.A, Ghilarov, D, Khabibullina, N.F, Yakimov, A, Shabalin, K, Utkina, I, Travin, D.Y, Komarova, E.S, Serebryakova, M, Artamonova, T, Khodorkovskii, M, Konevega, A.L, Sergiev, P.V, Severinov, K, Polikanov, Y.S. | Deposit date: | 2017-06-12 | Release date: | 2017-08-30 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel. Nat. Chem. Biol., 13, 2017
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7YPN
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![BU of 7ypn by Molmil](/molmil-images/mine/7ypn) | Crystal structure of transaminase CC1012 mutant M9 complexed with PLP | Descriptor: | 1,2-ETHANEDIOL, Aspartate aminotransferase family protein, DI(HYDROXYETHYL)ETHER, ... | Authors: | Yang, L, Wang, H, Wei, D. | Deposit date: | 2022-08-03 | Release date: | 2023-05-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.049 Å) | Cite: | Mechanism-Guided Computational Design of omega-Transaminase by Reprograming of High-Energy-Barrier Steps. Angew.Chem.Int.Ed.Engl., 61, 2022
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7YPM
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![BU of 7ypm by Molmil](/molmil-images/mine/7ypm) | Crystal structure of transaminase CC1012 complexed with PLP and L-alanine | Descriptor: | 1,2-ETHANEDIOL, ALANINE, Aspartate aminotransferase family protein, ... | Authors: | Yang, L, Wang, H, Wei, D. | Deposit date: | 2022-08-03 | Release date: | 2023-05-24 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.984 Å) | Cite: | Mechanism-Guided Computational Design of omega-Transaminase by Reprograming of High-Energy-Barrier Steps. Angew.Chem.Int.Ed.Engl., 61, 2022
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6M8Z
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![BU of 6m8z by Molmil](/molmil-images/mine/6m8z) | Crystal structure of human DJ-1 without a modification on Cys-106 | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, Protein/nucleic acid deglycase DJ-1 | Authors: | Shumilin, I.A, Shabalin, I.G, Shumilina, S.V, Werenskjold, C, Utepbergenov, D, Minor, W. | Deposit date: | 2018-08-22 | Release date: | 2018-09-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | A transient post-translational modification of active site cysteine alters binding properties of the parkinsonism protein DJ-1. Biochem. Biophys. Res. Commun., 504, 2018
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7ZKR
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![BU of 7zkr by Molmil](/molmil-images/mine/7zkr) | Human GABARAP in complex with stapled peptide Pen3-ortho | Descriptor: | CHLORIDE ION, Gamma-aminobutyric acid receptor-associated protein, ORTHO-XYLENE, ... | Authors: | Ueffing, A, Brown, H, Willbold, D, Kritzer, J.A, Weiergraeber, O.H. | Deposit date: | 2022-04-13 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Structure-Based Design of Stapled Peptides That Bind GABARAP and Inhibit Autophagy. J.Am.Chem.Soc., 144, 2022
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7ZL7
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![BU of 7zl7 by Molmil](/molmil-images/mine/7zl7) | Human GABARAP in complex with stapled peptide Pen8-ortho | Descriptor: | CHLORIDE ION, Gamma-aminobutyric acid receptor-associated protein, ORTHO-XYLENE, ... | Authors: | Ueffing, A, Brown, H, Willbold, D, Kritzer, J.A, Weiergraeber, O.H. | Deposit date: | 2022-04-14 | Release date: | 2022-08-31 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structure-Based Design of Stapled Peptides That Bind GABARAP and Inhibit Autophagy. J.Am.Chem.Soc., 144, 2022
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7DGW
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![BU of 7dgw by Molmil](/molmil-images/mine/7dgw) | De novo designed protein H4A2S | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, de novo designed protein H4A2S | Authors: | Xu, Y, Liao, S, Chen, Q, Liu, H. | Deposit date: | 2020-11-12 | Release date: | 2021-11-24 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
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7DGU
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![BU of 7dgu by Molmil](/molmil-images/mine/7dgu) | De novo designed protein H4A1R | Descriptor: | de novo designed protein H4A1R | Authors: | Xu, Y, Liao, S, Chen, Q, Liu, H. | Deposit date: | 2020-11-12 | Release date: | 2021-11-24 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
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7DKK
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![BU of 7dkk by Molmil](/molmil-images/mine/7dkk) | De novo design protein XM2H | Descriptor: | De novo design protein XM2H | Authors: | Bin, H. | Deposit date: | 2020-11-24 | Release date: | 2021-12-08 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
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7DKO
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![BU of 7dko by Molmil](/molmil-images/mine/7dko) | De novo design protein AM2M | Descriptor: | de novo designed protein AM2M | Authors: | Bin, H. | Deposit date: | 2020-11-25 | Release date: | 2021-12-08 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
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7DMF
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7DGY
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![BU of 7dgy by Molmil](/molmil-images/mine/7dgy) | De novo designed protein H4C2R | Descriptor: | de novo designed protein H4C2R | Authors: | Xu, Y, Liao, S, Chen, Q, Liu, H. | Deposit date: | 2020-11-12 | Release date: | 2021-12-15 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
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4NVJ
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4NVF
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4NVD
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4NVK
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![BU of 4nvk by Molmil](/molmil-images/mine/4nvk) | Predicting protein conformational response in prospective ligand discovery. | Descriptor: | Cytochrome c peroxidase, N~2~,N~2~-diethylquinazoline-2,4-diamine, PHOSPHATE ION, ... | Authors: | Fischer, M, Fraser, J.S. | Deposit date: | 2013-12-05 | Release date: | 2013-12-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Incorporation of protein flexibility and conformational energy penalties in docking screens to improve ligand discovery. Nat Chem, 6, 2014
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4NVG
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4NVE
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4NVO
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7URI
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![BU of 7uri by Molmil](/molmil-images/mine/7uri) | allo-tRNAUTu1A in the A site of the E. coli ribosome | Descriptor: | Allo-tRNAUTu1A | Authors: | Zhang, J, Prabhakar, A, Krahn, N, Vargas-Rodriguez, O, Krupkin, M, Fu, Z, Acosta-Reyes, F.J, Ge, X, Choi, J, Crnkovic, A, Ehrenberg, M, Viani Puglisi, E, Soll, D, Puglisi, J. | Deposit date: | 2022-04-22 | Release date: | 2022-08-10 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Uncovering translation roadblocks during the development of a synthetic tRNA. Nucleic Acids Res., 50, 2022
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7UR5
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![BU of 7ur5 by Molmil](/molmil-images/mine/7ur5) | allo-tRNAUTu1 in the A, P, and E sites of the E. coli ribosome | Descriptor: | allo-tRNAUTu1 | Authors: | Zhang, J, Krahn, N, Prabhakar, A, Vargas-Rodriguez, O, Krupkin, M, Fu, Z, Acosta-Reyes, F.J, Ge, X, Choi, J, Crnkovic, A, Ehrenberg, M, Viani Puglisi, E, Soll, D, Puglisi, J. | Deposit date: | 2022-04-21 | Release date: | 2022-08-10 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Uncovering translation roadblocks during the development of a synthetic tRNA. Nucleic Acids Res., 50, 2022
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7URM
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![BU of 7urm by Molmil](/molmil-images/mine/7urm) | allo-tRNAUTu1A in the P site of the E. coli ribosome | Descriptor: | allo-tRNAUTU1A | Authors: | Zhang, J, Prabhakar, A, Krahn, N, Vargas-Rodriguez, O, Krupkin, M, Fu, Z, Acosta-Reyes, F.J, Ge, X, Choi, J, Crnkovic, A, Ehrenberg, M, Viani Puglisi, E, Soll, D, Puglisi, J. | Deposit date: | 2022-04-22 | Release date: | 2022-08-10 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Uncovering translation roadblocks during the development of a synthetic tRNA. Nucleic Acids Res., 50, 2022
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7AZG
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![BU of 7azg by Molmil](/molmil-images/mine/7azg) | DNA polymerase sliding clamp from Escherichia coli with peptide 4 bound | Descriptor: | Beta sliding clamp, Peptide 4 | Authors: | Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y. | Deposit date: | 2020-11-16 | Release date: | 2021-12-01 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp. J.Med.Chem., 64, 2021
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7B4V
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![BU of 7b4v by Molmil](/molmil-images/mine/7b4v) | Broadly neutralizing DARPin bnD.2 in complex with the HIV-1 envelope variable loop 3 crown mimetic peptide V3-IF (BG505) | Descriptor: | Broadly neutralizing DARPin bnD.2, CHLORIDE ION, HIV-1 envelope variable loop 3 crown mimetic peptide V3-IF (BG505), ... | Authors: | Friedrich, N, Stiegeler, E, Glogl, M, Lemmin, T, Hansen, S, Kadelka, C, Wu, Y, Ernst, P, Maliqi, L, Foulkes, C, Morin, M, Eroglu, M, Liechti, T, Ivan, B, Reinberg, T, Schaefer, J, Karakus, U, Ursprung, S, Mann, A, Rusert, P, Kouyos, R.D, Robinson, J.A, Gunthard, H.F, Pluckthun, A, Trkola, A. | Deposit date: | 2020-12-02 | Release date: | 2021-11-24 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization. Nat Commun, 12, 2021
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7B4W
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![BU of 7b4w by Molmil](/molmil-images/mine/7b4w) | Broadly neutralizing DARPin bnD.3 in complex with the HIV-1 envelope variable loop 3 crown mimetic peptide V3-IF (BG505) | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, Broadly neutralizing DARPin bnD.3, ... | Authors: | Friedrich, N, Stiegeler, E, Glogl, M, Lemmin, T, Hansen, S, Kadelka, C, Wu, Y, Ernst, P, Maliqi, L, Foulkes, C, Morin, M, Eroglu, M, Liechti, T, Ivan, B, Reinberg, T, Schaefer, J, Karakus, U, Ursprung, S, Mann, A, Rusert, P, Kouyos, R.D, Robinson, J.A, Gunthard, H.F, Pluckthun, A, Trkola, A. | Deposit date: | 2020-12-02 | Release date: | 2021-11-24 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization. Nat Commun, 12, 2021
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