7B4V

Broadly neutralizing DARPin bnD.2 in complex with the HIV-1 envelope variable loop 3 crown mimetic peptide V3-IF (BG505)

Summary for 7B4V

Entry DOI	10.2210/pdb7b4v/pdb
Descriptor	Broadly neutralizing DARPin bnD.2, HIV-1 envelope variable loop 3 crown mimetic peptide V3-IF (BG505), CHLORIDE ION, ... (5 entities in total)
Functional Keywords	hiv, v3, conformation, neutralization, darpins, antibodies, de novo protein
Biological source	synthetic construct More
Total number of polymer chains	4
Total formula weight	30971.14
Authors	Friedrich, N.,Stiegeler, E.,Glogl, M.,Lemmin, T.,Hansen, S.,Kadelka, C.,Wu, Y.,Ernst, P.,Maliqi, L.,Foulkes, C.,Morin, M.,Eroglu, M.,Liechti, T.,Ivan, B.,Reinberg, T.,Schaefer, J.,Karakus, U.,Ursprung, S.,Mann, A.,Rusert, P.,Kouyos, R.D.,Robinson, J.A.,Gunthard, H.F.,Pluckthun, A.,Trkola, A. (deposition date: 2020-12-02, release date: 2021-11-24, Last modification date: 2022-06-15)
Primary citation	Friedrich, N.,Stiegeler, E.,Glogl, M.,Lemmin, T.,Hansen, S.,Kadelka, C.,Wu, Y.,Ernst, P.,Maliqi, L.,Foulkes, C.,Morin, M.,Eroglu, M.,Liechti, T.,Ivan, B.,Reinberg, T.,Schaefer, J.V.,Karakus, U.,Ursprung, S.,Mann, A.,Rusert, P.,Kouyos, R.D.,Robinson, J.A.,Gunthard, H.F.,Pluckthun, A.,Trkola, A. Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization. Nat Commun, 12:6705-6705, 2021 Cited by PubMed: 34795280 DOI: 10.1038/s41467-021-27075-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation