2QYU
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![BU of 2qyu by Molmil](/molmil-images/mine/2qyu) | Crystal structure of Salmonella effector protein SopA | Descriptor: | 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, PHOSPHATE ION, Secreted effector protein | Authors: | Diao, J, Chen, J. | Deposit date: | 2007-08-15 | Release date: | 2007-12-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase. Nat.Struct.Mol.Biol., 15, 2008
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6FTJ
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![BU of 6ftj by Molmil](/molmil-images/mine/6ftj) | Cryo-EM Structure of the Mammalian Oligosaccharyltransferase Bound to Sec61 and the Non-programmed 80S Ribosome | Descriptor: | 28S rRNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | Authors: | Braunger, K, Becker, T, Beckmann, R. | Deposit date: | 2018-02-22 | Release date: | 2018-03-21 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Structural basis for coupling protein transport and N-glycosylation at the mammalian endoplasmic reticulum. Science, 360, 2018
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4OJC
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![BU of 4ojc by Molmil](/molmil-images/mine/4ojc) | |
8DJM
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![BU of 8djm by Molmil](/molmil-images/mine/8djm) | HMGCR-UBIAD1 Complex State 1 | Descriptor: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, CHOLESTEROL HEMISUCCINATE, Digitonin, ... | Authors: | Chen, H, Qi, X, Li, X. | Deposit date: | 2022-07-01 | Release date: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain. Nat Commun, 13, 2022
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8DJK
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![BU of 8djk by Molmil](/molmil-images/mine/8djk) | HMGCR-UBIAD1 Complex State 2 | Descriptor: | 3-hydroxy-3-methylglutaryl-coenzyme A reductase, CHOLESTEROL HEMISUCCINATE, Digitonin, ... | Authors: | Chen, H, Qi, X, Li, X. | Deposit date: | 2022-06-30 | Release date: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | Regulated degradation of HMG CoA reductase requires conformational changes in sterol-sensing domain. Nat Commun, 13, 2022
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4OJE
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![BU of 4oje by Molmil](/molmil-images/mine/4oje) | |
4RQQ
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![BU of 4rqq by Molmil](/molmil-images/mine/4rqq) | |
2LXN
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![BU of 2lxn by Molmil](/molmil-images/mine/2lxn) | Solution NMR structure of glutamine amido transferase subunit of gaunosine monophosphate synthetase from Methanocaldococcus jannaschii | Descriptor: | GMP synthase [glutamine-hydrolyzing] subunit A | Authors: | Ali, R, Kumar, S, Balaram, H, Sarma, S.P. | Deposit date: | 2012-08-30 | Release date: | 2013-06-12 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | 1H, 13C, 15N assignment and secondary structure determination of glutamine amido transferase subunit of gaunosine monophosphate synthetase from Methanocaldococcus jannaschii Biomol.Nmr Assign., 6, 2012
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2BOV
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![BU of 2bov by Molmil](/molmil-images/mine/2bov) | Molecular recognition of an ADP-ribosylating Clostridium botulinum C3 exoenzyme by RalA GTPase | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MONO-ADP-RIBOSYLTRANSFERASE C3, ... | Authors: | Holbourn, K.P, Sutton, J.M, Evans, H.R, Shone, C.C, Acharya, K.R. | Deposit date: | 2005-04-14 | Release date: | 2005-04-15 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | Molecular Recognition of an Adp-Ribosylating Clostridium Botulinum C3 Exoenzyme by Rala Gtpase Proc.Natl.Acad.Sci.USA, 102, 2005
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4BBE
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![BU of 4bbe by Molmil](/molmil-images/mine/4bbe) | Aminoalkylpyrimidine Inhibitor Complexes with JAK2 | Descriptor: | N-[4-[2-[(4-morpholin-4-ylphenyl)amino]pyrimidin-4-yl]phenyl]ethanamide, TYROSINE-PROTEIN KINASE JAK2 | Authors: | Li, J. | Deposit date: | 2012-09-21 | Release date: | 2012-11-21 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Sar and in Vivo Evaluation of 4-Aryl-2-Aminoalkylpyrimidines as Potent and Selective Janus Kinase 2 (Jak2) Inhibitors Bioorg.Med.Chem.Lett., 22, 2012
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4UFU
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![BU of 4ufu by Molmil](/molmil-images/mine/4ufu) | Crystal structure of human tankyrase 2 in complex with TA-12 | Descriptor: | 8-methyl-2-[4-(trifluoromethyl)phenyl]-3H-quinazolin-4-one, GLYCEROL, SULFATE ION, ... | Authors: | Haikarainen, T, Lehtio, L. | Deposit date: | 2015-03-19 | Release date: | 2016-04-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases. Eur.J.Med.Chem., 118, 2016
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1OFI
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![BU of 1ofi by Molmil](/molmil-images/mine/1ofi) | Asymmetric complex between HslV and I-domain deleted HslU (H. influenzae) | Descriptor: | 4-IODO-3-NITROPHENYL ACETYL-LEUCINYL-LEUCINYL-LEUCINYL-VINYLSULFONE, ADENOSINE-5'-DIPHOSPHATE, ATP-DEPENDENT HSL PROTEASE ATP-BINDING SUBUNIT HSLU, ... | Authors: | Kwon, A.R, Kessler, B.M, Overkleeft, H.S, McKay, D.B. | Deposit date: | 2003-04-14 | Release date: | 2003-07-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure and Reactivity of an Asymmetric Complex between Hslv and I-Domain Deleted Hslu, a Prokaryotic Homolog of the Eukaryotic Proteasome J.Mol.Biol., 330, 2003
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5MCP
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![BU of 5mcp by Molmil](/molmil-images/mine/5mcp) | Structure of IMP dehydrogenase from Ashbya gossypii bound to ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Inosine-5'-monophosphate dehydrogenase, MAGNESIUM ION | Authors: | Winter, G, Fernandez-Justel, D, de Pereda, J.M, Revuelta, J.L, Buey, R.M. | Deposit date: | 2016-11-10 | Release date: | 2017-06-14 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | A nucleotide-controlled conformational switch modulates the activity of eukaryotic IMP dehydrogenases. Sci Rep, 7, 2017
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8E5F
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![BU of 8e5f by Molmil](/molmil-images/mine/8e5f) | Cryo-EM of P. calidifontis cytochrome filament | Descriptor: | HEME C, c-type cytochrome | Authors: | Wang, F, Cvirkaite-Krupovic, V, Krupovic, M, Egelman, E.H. | Deposit date: | 2022-08-22 | Release date: | 2023-05-10 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Extracellular cytochrome nanowires appear to be ubiquitous in prokaryotes. Cell, 186, 2023
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1OFH
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![BU of 1ofh by Molmil](/molmil-images/mine/1ofh) | Asymmetric complex between HslV and I-domain deleted HslU (H. influenzae) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ATP-DEPENDENT HSL PROTEASE ATP-BINDING SUBUNIT HSLU, ATP-DEPENDENT PROTEASE HSLV, ... | Authors: | Kwon, A.R, Kessler, B.M, Overkleeft, H.S, McKay, D.B. | Deposit date: | 2003-04-14 | Release date: | 2003-07-03 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure and Reactivity of an Asymmetric Complex between Hslv and I-Domain Deleted Hslu, a Prokaryotic Homolog of the Eukaryotic Proteasome J.Mol.Biol., 330, 2003
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4UFY
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![BU of 4ufy by Molmil](/molmil-images/mine/4ufy) | Crystal structure of human tankyrase 2 in complex with TA-13 | Descriptor: | 8-METHYL-2-(4-METHYLPHENYL)-3,4-DIHYDROQUINAZOLIN-4-ONE, GLYCEROL, SULFATE ION, ... | Authors: | Haikarainen, T, Lehtio, L. | Deposit date: | 2015-03-20 | Release date: | 2016-04-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases. Eur.J.Med.Chem., 118, 2016
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8E5G
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![BU of 8e5g by Molmil](/molmil-images/mine/8e5g) | Cryo-EM of A. veneficus cytochrome filament | Descriptor: | HEME C, c-type cytochrome | Authors: | Wang, F, Baquero, D.P, Krupovic, M, Egelman, E.H. | Deposit date: | 2022-08-22 | Release date: | 2023-05-10 | Last modified: | 2023-07-26 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Extracellular cytochrome nanowires appear to be ubiquitous in prokaryotes. Cell, 186, 2023
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4UI8
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![BU of 4ui8 by Molmil](/molmil-images/mine/4ui8) | Crystal structure of human tankyrase 2 in complex with TA-55 | Descriptor: | 8-HYDROXY-2-[4-(TRIFLUOROMETHYL)PHENYL]-3,4-DIHYDROQUINAZOLIN-4-ONE, GLYCEROL, SULFATE ION, ... | Authors: | Haikarainen, T, Lehtio, L. | Deposit date: | 2015-03-27 | Release date: | 2016-04-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases. Eur.J.Med.Chem., 118, 2016
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4UI7
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![BU of 4ui7 by Molmil](/molmil-images/mine/4ui7) | Crystal structure of human tankyrase 2 in complex with TA-49 | Descriptor: | 8-HYDROXY-2-(4-METHYLPHENYL)-3,4-DIHYDROQUINAZOLIN-4-ONE, GLYCEROL, SULFATE ION, ... | Authors: | Haikarainen, T, Lehtio, L. | Deposit date: | 2015-03-27 | Release date: | 2016-04-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases. Eur.J.Med.Chem., 118, 2016
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8DP1
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![BU of 8dp1 by Molmil](/molmil-images/mine/8dp1) | Cryo-EM structure of HIV-1 Env(BG505.T332N SOSIP) in complex with DH1030.1 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DH1030.1 Fab Heavy chain, ... | Authors: | Gobeil, S, Acharya, P. | Deposit date: | 2022-07-14 | Release date: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.46 Å) | Cite: | Shared recognition mechanism for HIV-1 envelope-reactive V3 glycan broadly neutralizing B cell lineage maturation in humans and macaques To Be Published
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2Y0A
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![BU of 2y0a by Molmil](/molmil-images/mine/2y0a) | Structure of DAPK1 construct residues 1-304 | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DEATH-ASSOCIATED PROTEIN KINASE 1 | Authors: | Yumerefendi, H, Mas, P.J, Dordevic, N, McCarthy, A.A, Hart, D.J. | Deposit date: | 2010-12-01 | Release date: | 2011-12-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Library-Based Construct Screening of Death-Associated Protein Kinase 1 Identifies the Minimal Calmodulin Interaction Region and Autoinhibitory Conformation of the Catalytic Domain To be Published
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8DOW
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![BU of 8dow by Molmil](/molmil-images/mine/8dow) | Cryo-EM structure of HIV-1 Env(CH848 10.17 DS.SOSIP_DT) in complex with DH1030.1 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DH1030.1 Fab Heavy chain, ... | Authors: | Gobeil, S, Acharya, P. | Deposit date: | 2022-07-14 | Release date: | 2023-07-19 | Method: | ELECTRON MICROSCOPY (3.69 Å) | Cite: | Shared recognition mechanism for HIV-1 envelope-reactive V3 glycan broadly neutralizing B cell lineage maturation in humans and macaques To Be Published
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8DTK
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1NQA
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![BU of 1nqa by Molmil](/molmil-images/mine/1nqa) | Glyceraldehyde-3-Phosphate Dehydrogenase Mutant With Cys 149 Replaced By Ala Complexed With Nad+ and D-Glyceraldehyde-3-Phosphate | Descriptor: | GLYCERALDEHYDE-3-PHOSPHATE, Glyceraldehyde 3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | Authors: | Didierjean, C, Corbier, C, Fatih, M, Favier, F, Boschi-Muller, S, Branlant, G, Aubry, A. | Deposit date: | 2003-01-21 | Release date: | 2003-04-22 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of two ternary complexes of phosphorylating
Glyceraldehyde-3-Phosphate Dehydrogenase from Bacillus stearothermophilus
with NAD and D-Glyceraldehyde-3-Phosphate J.Biol.Chem., 278, 2003
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4UI4
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![BU of 4ui4 by Molmil](/molmil-images/mine/4ui4) | Crystal structure of human tankyrase 2 in complex with TA-29 | Descriptor: | BENZYL N-{[4-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)PHENYL]METHYL}CARBAMATE, SULFATE ION, TANKYRASE-2, ... | Authors: | Haikarainen, T, Lehtio, L. | Deposit date: | 2015-03-27 | Release date: | 2016-04-13 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases. Eur.J.Med.Chem., 118, 2016
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