4UFU
Crystal structure of human tankyrase 2 in complex with TA-12
Summary for 4UFU
Entry DOI | 10.2210/pdb4ufu/pdb |
Descriptor | TANKYRASE-2, ZINC ION, SULFATE ION, ... (6 entities in total) |
Functional Keywords | transferase, protein-ligand complex, diphtheria toxin like fold, adp- ribosylation, transferase-transferase inhibitor complex |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Cytoplasm: Q9H2K2 |
Total number of polymer chains | 2 |
Total formula weight | 55907.32 |
Authors | Haikarainen, T.,Lehtio, L. (deposition date: 2015-03-19, release date: 2016-04-13, Last modification date: 2024-05-08) |
Primary citation | Nathubhai, A.,Haikarainen, T.,Hayward, P.C.,Munoz-Descalzo, S.,Thompson, A.S.,Lloyd, M.D.,Lehtio, L.,Threadgill, M.D. Structure-Activity Relationships of 2-Arylquinazolin-4-Ones as Highly Selective and Potent Inhibitors of the Tankyrases. Eur.J.Med.Chem., 118:316-, 2016 Cited by PubMed: 27163581DOI: 10.1016/J.EJMECH.2016.04.041 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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