8E4P
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8e4p by Molmil](/molmil-images/mine/8e4p) | Mouse TRPM8 structure determined in the ligand- and PI(4,5)P2-free condition, Class I , C0 state | Descriptor: | CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8 | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | Deposit date: | 2022-08-18 | Release date: | 2022-10-26 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.59 Å) | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
|
|
8E4M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8e4m by Molmil](/molmil-images/mine/8e4m) | The intermediate C2-state mouse TRPM8 structure in complex with the cooling agonist C3 and PI(4,5)P2 | Descriptor: | CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ... | Authors: | Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y. | Deposit date: | 2022-08-18 | Release date: | 2022-10-26 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2. Science, 378, 2022
|
|
8DDW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ddw by Molmil](/molmil-images/mine/8ddw) | |
8DDX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ddx by Molmil](/molmil-images/mine/8ddx) | cryo-EM structure of TRPM3 ion channel in complex with Gbg in the presence of PIP2, tethered by ALFA-nanobody | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhao, C, MacKinnon, R. | Deposit date: | 2022-06-19 | Release date: | 2022-11-02 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. Neuron, 111, 2023
|
|
5WP6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5wp6 by Molmil](/molmil-images/mine/5wp6) | Cryo-EM structure of a human TRPM4 channel in complex with calcium and decavanadate | Descriptor: | DECAVANADATE, Transient receptor potential cation channel subfamily M member 4 | Authors: | Winkler, P.A, Huang, Y, Sun, W, Du, J, Lu, W. | Deposit date: | 2017-08-03 | Release date: | 2017-12-13 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Electron cryo-microscopy structure of a human TRPM4 channel. Nature, 552, 2017
|
|
7LPE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7lpe by Molmil](/molmil-images/mine/7lpe) | Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an open state, class 1 | Descriptor: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | Deposit date: | 2021-02-11 | Release date: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.72 Å) | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
|
|
7LPA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7lpa by Molmil](/molmil-images/mine/7lpa) | Cryo-EM structure of full-length TRPV1 with capsaicin at 4 degrees Celsius | Descriptor: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ... | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | Deposit date: | 2021-02-11 | Release date: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.37 Å) | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
|
|
7LPB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7lpb by Molmil](/molmil-images/mine/7lpb) | Cryo-EM structure of full-length TRPV1 with capsaicin at 25 degrees Celsius | Descriptor: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ... | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | Deposit date: | 2021-02-11 | Release date: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
|
|
7LPD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7lpd by Molmil](/molmil-images/mine/7lpd) | Cryo-EM structure of full-length TRPV1 with capsaicin at 48 degrees Celsius, in an intermediate state, class 2 | Descriptor: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, Transient receptor potential cation channel subfamily V member 1, ... | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | Deposit date: | 2021-02-11 | Release date: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.55 Å) | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
|
|
7LP9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7lp9 by Molmil](/molmil-images/mine/7lp9) | Cryo-EM structure of full-length TRPV1 at 4 degrees Celsius | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ... | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | Deposit date: | 2021-02-11 | Release date: | 2021-07-28 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.63 Å) | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
|
|
7LPC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7lpc by Molmil](/molmil-images/mine/7lpc) | Cryo-EM structure of full-length TRPV1 at 48 degrees Celsius | Descriptor: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, Phosphatidylinositol, ... | Authors: | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | Deposit date: | 2021-02-11 | Release date: | 2021-07-28 | Method: | ELECTRON MICROSCOPY (3.06 Å) | Cite: | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
|
|
2ETC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2etc by Molmil](/molmil-images/mine/2etc) | Crystal structure of the ankyrin repeat domain of TRPV2 | Descriptor: | Transient receptor potential cation channel subfamily V member 2 | Authors: | Jin, X, Gaudet, R. | Deposit date: | 2005-10-27 | Release date: | 2006-06-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of the N-terminal Ankyrin Repeat Domain of the TRPV2 Ion Channel. J.Biol.Chem., 281, 2006
|
|
2ETA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2eta by Molmil](/molmil-images/mine/2eta) | |
2ETB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2etb by Molmil](/molmil-images/mine/2etb) | Crystal structure of the ankyrin repeat domain of TRPV2 | Descriptor: | ACETIC ACID, Transient receptor potential cation channel subfamily V member 2 | Authors: | Jin, X, Gaudet, R. | Deposit date: | 2005-10-27 | Release date: | 2006-06-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure of the N-terminal Ankyrin Repeat Domain of the TRPV2 Ion Channel. J.Biol.Chem., 281, 2006
|
|
8JU5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ju5 by Molmil](/molmil-images/mine/8ju5) | Structure of human TRPV4 with antagonist A1 | Descriptor: | 4-[(3~{S},4~{S})-4-(aminomethyl)-1-(5-chloranylpyridin-2-yl)sulfonyl-4-oxidanyl-pyrrolidin-3-yl]oxy-2-fluoranyl-benzenecarbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | Authors: | Fan, J, Lei, X. | Deposit date: | 2023-06-24 | Release date: | 2024-05-08 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.74 Å) | Cite: | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 11, 2024
|
|
8JVI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jvi by Molmil](/molmil-images/mine/8jvi) | Structure of human TRPV4 with antagonist A2 | Descriptor: | Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | Authors: | Fan, J, Lei, X. | Deposit date: | 2023-06-28 | Release date: | 2024-05-08 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 11, 2024
|
|
8JVJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jvj by Molmil](/molmil-images/mine/8jvj) | Structure of human TRPV4 with antagonist A2 and RhoA | Descriptor: | Transforming protein RhoA, Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | Authors: | Fan, J, Lei, X. | Deposit date: | 2023-06-28 | Release date: | 2024-05-08 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.44 Å) | Cite: | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 11, 2024
|
|
8JU6
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ju6 by Molmil](/molmil-images/mine/8ju6) | Structure of human TRPV4 with antagonist GSK279 | Descriptor: | 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | Authors: | Fan, J, Lei, X. | Deposit date: | 2023-06-24 | Release date: | 2024-05-08 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 11, 2024
|
|
8JQR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jqr by Molmil](/molmil-images/mine/8jqr) | Structure of human TRPV1 in complex with antagonist | Descriptor: | 4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile, CHOLESTEROL, Transient receptor potential cation channel subfamily V member 1,PreScission Site,Green fluorescent protein | Authors: | Fan, J, Lei, X. | Deposit date: | 2023-06-14 | Release date: | 2024-08-14 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.75 Å) | Cite: | Structural basis of TRPV1 inhibition by SAF312 and cholesterol. Nat Commun, 15, 2024
|
|
8X94
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8x94 by Molmil](/molmil-images/mine/8x94) | Structure of human TRPV1 in complex with antagonist --protein purified without CHS | Descriptor: | 4-(7-Hydroxy-2-isopropyl-4-oxoquinazolin-3(4H)-yl)benzonitrile, CHOLESTEROL, Transient receptor potential cation channel subfamily V member 1,Green fluorescent protein | Authors: | Fan, J, Lei, X. | Deposit date: | 2023-11-29 | Release date: | 2024-08-14 | Last modified: | 2024-08-21 | Method: | ELECTRON MICROSCOPY (2.55 Å) | Cite: | Structural basis of TRPV1 inhibition by SAF312 and cholesterol. Nat Commun, 15, 2024
|
|
7VQ1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vq1 by Molmil](/molmil-images/mine/7vq1) | Structure of Apo-hsTRPM2 channel | Descriptor: | Transient receptor potential cation channel subfamily M member 2 | Authors: | Yu, X.F, Xie, Y, Zhang, X.K, Ma, C, Guo, J.T, Yang, F, Yang, W. | Deposit date: | 2021-10-18 | Release date: | 2021-12-22 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.76 Å) | Cite: | Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel. Cell Rep, 37, 2021
|
|
7VQ2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vq2 by Molmil](/molmil-images/mine/7vq2) | Structure of Apo-hsTRPM2 channel TM domain | Descriptor: | Transient receptor potential cation channel subfamily M member 2 | Authors: | Yu, X.F, Xie, Y, Zhang, X.K, Ma, C, Guo, J.T, Yang, F, Yang, W. | Deposit date: | 2021-10-18 | Release date: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel. Cell Rep, 37, 2021
|
|
7WRA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wra by Molmil](/molmil-images/mine/7wra) | Mouse TRPM8 in LMNG in ligand-free state | Descriptor: | SODIUM ION, Transient receptor potential cation channel subfamily M member 8 | Authors: | Zhao, C, Xie, Y, Guo, J. | Deposit date: | 2022-01-26 | Release date: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structures of a mammalian TRPM8 in closed state. Nat Commun, 13, 2022
|
|
7WRD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wrd by Molmil](/molmil-images/mine/7wrd) | |
7WRF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wrf by Molmil](/molmil-images/mine/7wrf) | Mouse TRPM8 in lipid nanodiscs in the presence of calcium, icilin and PI(4,5)P2 | Descriptor: | CALCIUM ION, Icilin, SODIUM ION, ... | Authors: | Zhao, C, Xie, Y, Guo, J. | Deposit date: | 2022-01-26 | Release date: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Structures of a mammalian TRPM8 in closed state. Nat Commun, 13, 2022
|
|