5YB8
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![BU of 5yb8 by Molmil](/molmil-images/mine/5yb8) | L-Amino acid oxidase/monooxygenase from Pseudomonas sp. AIU 813 - L-arginine complex | Descriptor: | ARGININE, FLAVIN-ADENINE DINUCLEOTIDE, L-amino acid oxidase/monooxygenase | Authors: | Im, D, Matsui, D, Arakawa, T, Isobe, K, Asano, Y, Fushinobu, S. | Deposit date: | 2017-09-03 | Release date: | 2018-02-07 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Ligand complex structures of l-amino acid oxidase/monooxygenase from FEBS Open Bio, 8, 2018
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5V3O
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![BU of 5v3o by Molmil](/molmil-images/mine/5v3o) | Cereblon in complex with DDB1 and CC-220 | Descriptor: | (3S)-3-[4-({4-[(morpholin-4-yl)methyl]phenyl}methoxy)-1-oxo-1,3-dihydro-2H-isoindol-2-yl]piperidine-2,6-dione, DNA damage-binding protein 1, Protein cereblon, ... | Authors: | Matyskiela, M, Pagarigan, B, Chamberlain, P. | Deposit date: | 2017-03-07 | Release date: | 2017-05-03 | Last modified: | 2018-02-07 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos. J. Med. Chem., 61, 2018
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2XNU
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![BU of 2xnu by Molmil](/molmil-images/mine/2xnu) | Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors | Descriptor: | 2-(2-(4-PHENYLPIPERIDIN-1-YL)ETHYL)-1H-INDOLE, SOLUBLE ACETYLCHOLINE RECEPTOR | Authors: | Rucktooa, P, Akdemir, A, deEsch, I, Sixma, T.K. | Deposit date: | 2010-08-06 | Release date: | 2011-08-24 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Acetylcholine Binding Protein (Achbp) as Template for Hierarchical in Silico Screening Procedures to Identify Structurally Novel Ligands for the Nicotinic Receptors. Bioorg.Med.Chem., 19, 2011
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4BE8
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![BU of 4be8 by Molmil](/molmil-images/mine/4be8) | NEDD4 HECT A889F structure | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE NEDD4 | Authors: | Maspero, E, Valentini, E, Mari, S, Cecatiello, V, Polo, S, Pasqualato, S. | Deposit date: | 2013-03-06 | Release date: | 2013-05-01 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.996 Å) | Cite: | Structure of a Ubiquitin-Loaded Hect Ligase Reveals the Molecular Basis for Catalytic Priming Nat.Struct.Mol.Biol., 20, 2013
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6NDL
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![BU of 6ndl by Molmil](/molmil-images/mine/6ndl) | Crystal structure of Staphylococcus aureus biotin protein ligase in complex with a sulfonamide inhibitor | Descriptor: | 1-[4-(6-aminopurin-9-yl)butylsulfamoyl]-3-[4-[(4~{S})-2-oxidanylidene-1,3,3~{a},4,6,6~{a}-hexahydrothieno[3,4-d]imidazol-4-yl]butyl]urea, Biotin Protein Ligase, GLYCEROL | Authors: | Marshall, A.C, Polyak, S.W, Bruning, J.B, Lee, K. | Deposit date: | 2018-12-13 | Release date: | 2019-12-18 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Sulfonamide-Based Inhibitors of Biotin Protein Ligase as New Antibiotic Leads. Acs Chem.Biol., 14, 2019
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5V0I
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![BU of 5v0i by Molmil](/molmil-images/mine/5v0i) | Crystal Structure of Tryptophanyl-tRNA Synthetase from Escherichia coli Complexed with AMP and Tryptophan | Descriptor: | ADENOSINE MONOPHOSPHATE, FORMIC ACID, TRYPTOPHAN, ... | Authors: | Maltseva, N, Kim, Y, Mulligan, R, Grimshaw, S.G, Joachimiak, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2017-02-28 | Release date: | 2017-03-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structure of Tryptophanyl-tRNA Synthetase from Escherichia coli Complexed with AMP and Tryptophan To Be Published
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6NZE
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![BU of 6nze by Molmil](/molmil-images/mine/6nze) | |
6NZH
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7JL1
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![BU of 7jl1 by Molmil](/molmil-images/mine/7jl1) | Cryo-EM structure of RIG-I:dsRNA in complex with RIPLET PrySpry domain (monomer) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Antiviral innate immune response receptor RIG-I, E3 ubiquitin-protein ligase RNF135, ... | Authors: | Kato, K, Ahmad, S, Hur, S. | Deposit date: | 2020-07-29 | Release date: | 2020-12-09 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural analysis of RIG-I-like receptors reveals ancient rules of engagement between diverse RNA helicases and TRIM ubiquitin ligases. Mol.Cell, 81, 2021
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6NZF
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4NWD
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![BU of 4nwd by Molmil](/molmil-images/mine/4nwd) | Crystal structure of the kainate receptor GluK3 ligand-binding domain in complex with the agonist (2S,4R)-4-(3-Methylamino-3-oxopropyl)glutamic acid at 2.6 A resolution | Descriptor: | (4R)-4-[3-(methylamino)-3-oxopropyl]-L-glutamic acid, CHLORIDE ION, Glutamate receptor ionotropic, ... | Authors: | Venskutonyte, R, Larsen, A.P, Frydenvang, K, Gajhede, M, Kastrup, J.S. | Deposit date: | 2013-12-06 | Release date: | 2014-08-06 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Molecular Recognition of Two 2,4-syn-Functionalized (S)-Glutamate Analogues by the Kainate Receptor GluK3 Ligand Binding Domain. Chemmedchem, 9, 2014
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6WOM
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3MJ5
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![BU of 3mj5 by Molmil](/molmil-images/mine/3mj5) | Severe Acute Respiratory Syndrome-Coronavirus Papain-Like Protease Inhibitors: Design, Synthesis, Protein-Ligand X-ray Structure and Biological Evaluation | Descriptor: | N-(1,3-benzodioxol-5-ylmethyl)-1-[(1R)-1-naphthalen-1-ylethyl]piperidine-4-carboxamide, Replicase polyprotein 1a, ZINC ION | Authors: | Mesecar, A.D, Ratia, K.M, Pegan, S.D. | Deposit date: | 2010-04-12 | Release date: | 2010-06-30 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.63 Å) | Cite: | Severe acute respiratory syndrome coronavirus papain-like novel protease inhibitors: design, synthesis, protein-ligand X-ray structure and biological evaluation J.Med.Chem., 53, 2010
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6A22
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![BU of 6a22 by Molmil](/molmil-images/mine/6a22) | Ternary complex of Human ROR gamma Ligand Binding Domain With Compound T. | Descriptor: | 2-[2-[1-~{tert}-butyl-5-(4-methoxyphenyl)pyrazol-4-yl]-1,3-thiazol-4-yl]-~{N}-(oxan-4-ylmethyl)ethanamide, Nuclear receptor ROR-gamma, Nuclear receptor corepressor 2 | Authors: | Noguchi, M, Nomura, A, Doi, S, Yamaguchi, K, Adachi, T. | Deposit date: | 2018-06-08 | Release date: | 2018-12-12 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Ternary crystal structure of human ROR gamma ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction Sci Rep, 8, 2018
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2XNT
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![BU of 2xnt by Molmil](/molmil-images/mine/2xnt) | Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors | Descriptor: | (2S)-2-[(4-CHLOROBENZYL)OXY]-2-PHENYLETHANAMINE, BROMIDE ION, SOLUBLE ACETYLCHOLINE RECEPTOR | Authors: | Rucktooa, P, Akdemir, A, deEsch, I, Sixma, T.K. | Deposit date: | 2010-08-06 | Release date: | 2011-08-24 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | Acetylcholine Binding Protein (Achbp) as Template for Hierarchical in Silico Screening Procedures to Identify Structurally Novel Ligands for the Nicotinic Receptors. Bioorg.Med.Chem., 19, 2011
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2XNV
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![BU of 2xnv by Molmil](/molmil-images/mine/2xnv) | Acetylcholine binding protein (AChBP) as template for hierarchical in silico screening procedures to identify structurally novel ligands for the nicotinic receptors | Descriptor: | 2-(2-(4-PHENYLPIPERIDIN-1-YL)ETHYL)-1H-INDOLE, SOLUBLE ACETYLCHOLINE RECEPTOR | Authors: | Rucktooa, P, Akdemir, A, deEsch, I, Sixma, T.K. | Deposit date: | 2010-08-06 | Release date: | 2011-08-24 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Acetylcholine Binding Protein (Achbp) as Template for Hierarchical in Silico Screening Procedures to Identify Structurally Novel Ligands for the Nicotinic Receptors. Bioorg.Med.Chem., 19, 2011
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3EE4
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![BU of 3ee4 by Molmil](/molmil-images/mine/3ee4) | R2-like ligand binding Mn/Fe oxidase from M. tuberculosis | Descriptor: | FE (III) ION, MANGANESE (III) ION, MYRISTIC ACID, ... | Authors: | Andersson, C.S, Jones, T.A, Hogbom, M. | Deposit date: | 2008-09-04 | Release date: | 2009-04-07 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | A Mycobacterium tuberculosis ligand-binding Mn/Fe protein reveals a new cofactor in a remodeled R2-protein scaffold Proc.Natl.Acad.Sci.Usa, 106, 2009
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6ITS
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2CMO
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![BU of 2cmo by Molmil](/molmil-images/mine/2cmo) | The structure of a mixed glur2 ligand-binding core dimer in complex with (s)-glutamate and the antagonist (s)-ns1209 | Descriptor: | 2-({[(3E)-5-{4-[(DIMETHYLAMINO)(DIHYDROXY)-LAMBDA~4~-SULFANYL]PHENYL}-8-METHYL-2-OXO-6,7,8,9-TETRAHYDRO-1H-PYRROLO[3,2-H]ISOQUINOLIN-3(2H)-YLIDENE]AMINO}OXY)-4-HYDROXYBUTANOIC ACID, GLUTAMATE RECEPTOR 2, GLUTAMIC ACID, ... | Authors: | Kasper, C, Pickering, D.S, Mirza, O, Olsen, L, Kristensen, A.S, Greenwood, J.R, Liljefors, T, Schousboe, A, Watjen, F, Gajhede, M, Sigurskjold, B.W, Kastrup, J.S. | Deposit date: | 2006-05-11 | Release date: | 2006-06-06 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | The Structure of a Mixed Glur2 Ligand-Binding Core Dimer in Complex with (S)-Glutamate and the Antagonist (S)-Ns1209. J.Mol.Biol., 357, 2006
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1IKE
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![BU of 1ike by Molmil](/molmil-images/mine/1ike) | Crystal Structure of Nitrophorin 4 from Rhodnius Prolixus Complexed with Histamine at 1.5 A Resolution | Descriptor: | HISTAMINE, Nitrophorin 4, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Roberts, S.A, Weichsel, A, Qiu, Y, Shelnutt, J.A, Walker, F.A, Montfort, W.R. | Deposit date: | 2001-05-03 | Release date: | 2001-10-03 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Ligand-induced heme ruffling and bent no geometry in ultra-high-resolution structures of nitrophorin 4. Biochemistry, 40, 2001
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4C8F
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![BU of 4c8f by Molmil](/molmil-images/mine/4c8f) | mouse ZNRF3 ectodomain crystal form IV | Descriptor: | E3 UBIQUITIN-PROTEIN LIGASE ZNRF3 | Authors: | Zebisch, M, Jones, E.Y. | Deposit date: | 2013-09-30 | Release date: | 2013-11-20 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.69 Å) | Cite: | Structural and Molecular Basis of Znrf3/Rnf43 Transmembrane Ubiquitin Ligase Inhibition by the Wnt Agonist R-Spondin. Nat.Commun., 4, 2013
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1FTJ
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3KJ6
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![BU of 3kj6 by Molmil](/molmil-images/mine/3kj6) | Crystal structure of a Methylated beta2 Adrenergic Receptor-Fab complex | Descriptor: | Beta-2 adrenergic receptor, Fab heavy chain, Fab light chain, ... | Authors: | Bokoch, M.P, Zou, Y, Rasmussen, S.G.F, Liu, C.W, Nygaard, R, Rosenbaum, D.M, Fung, J.J, Choi, H.-J, Thian, F.S, Kobilka, T.S, Puglisi, J.D, Weis, W.I, Pardo, L, Prosser, S, Mueller, L, Kobilka, B.K. | Deposit date: | 2009-11-02 | Release date: | 2010-02-16 | Last modified: | 2021-10-13 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature, 463, 2010
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6I5X
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![BU of 6i5x by Molmil](/molmil-images/mine/6i5x) | Crystal structure of Aspergillus fumigatus phosphomannomutase | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | Authors: | Zhang, Y, Raimi, O.G, Ferenbach, A.T, van Aalten, D.M.F. | Deposit date: | 2018-11-15 | Release date: | 2019-11-27 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of Aspergillus fumigatus phosphomannomutase To Be Published
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2LAO
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![BU of 2lao by Molmil](/molmil-images/mine/2lao) | THREE-DIMENSIONAL STRUCTURES OF THE PERIPLASMIC LYSINE-, ARGININE-, ORNITHINE-BINDING PROTEIN WITH AND WITHOUT A LIGAND | Descriptor: | LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN | Authors: | Kim, S.-H, Oh, B.-H, Kang, C.-H. | Deposit date: | 1993-02-25 | Release date: | 1994-06-22 | Last modified: | 2017-11-29 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Three-dimensional structures of the periplasmic lysine/arginine/ornithine-binding protein with and without a ligand. J.Biol.Chem., 268, 1993
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