PDB: 222624 resultsInfo pagesStatus searchChemie searchBIRD

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8U5Y	human RADX trimer bound to ssDNA Descriptor: DNA (25-MER), RPA-related protein RADX Authors: Balakrishnan, S, Chazin, W.J. Deposit date: 2023-09-13 Release date: 2023-10-11 Last modified: 2023-10-18 Method: ELECTRON MICROSCOPY (3.01 Å) Cite: Structure of RADX and mechanism for regulation of RAD51 nucleofilaments. Biorxiv, 2023
8U5T	Structure of Mango II variant aptamer bound to T01-6A-B Descriptor: 3-{2,16-dioxo-20-[(3aS,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-6,9,12-trioxa-3,15-diazaicosan-1-yl}-2-{(E)-[6-(4-methoxyphenyl)-1-methylquinolin-4(1H)-ylidene]methyl}-1,3-benzothiazol-3-ium, Mango II variant, POTASSIUM ION, ... Authors: Passalacqua, L.F.M, Ferre-D'Amare, A.R. Deposit date: 2023-09-12 Release date: 2024-03-27 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Structure of Mango II variant aptamer bound to T01-6A-B To Be Published
8U5R	Structure of Mango II variant aptamer bound to T01-6A Descriptor: Mango II variant, POTASSIUM ION, SODIUM ION Authors: Passalacqua, L.F.M, Ferre-D'Amare, A.R. Deposit date: 2023-09-12 Release date: 2024-03-27 Method: X-RAY DIFFRACTION (2.6 Å) Cite: Structure of Mango II variant aptamer bound to T01-6A To Be Published
8U5P	Structure of Mango II aptamer bound to T01-6A-B Descriptor: 3-[2,16-dioxo-20-(2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-6,9,12-trioxa-3,15-diazaicosan-1-yl]-2-{(E)-[6-(4-methoxyphenyl)-1-methylquinolin-4(1H)-ylidene]methyl}-1,3-benzothiazol-3-ium, Mango II, POTASSIUM ION Authors: Passalacqua, L.F.M, Ferre-D'Amare, A.R. Deposit date: 2023-09-12 Release date: 2024-03-27 Method: X-RAY DIFFRACTION (2.9 Å) Cite: Structure of Mango II aptamer bound to T01-6A-B To Be Published
8U5M	Structure of Sts-1 HP domain with rebamipide Descriptor: Rebamipide, Ubiquitin-associated and SH3 domain-containing protein B Authors: Azia, F, Dey, R, French, J.B. Deposit date: 2023-09-12 Release date: 2024-02-07 Last modified: 2024-02-21 Method: X-RAY DIFFRACTION (2.46 Å) Cite: Rebamipide and Derivatives are Potent, Selective Inhibitors of Histidine Phosphatase Activity of the Suppressor of T Cell Receptor Signaling Proteins. J.Med.Chem., 67, 2024
8U5K	Structure of Mango II aptamer bound to T01-6A Descriptor: 2-[(~{E})-[6-(4-methoxyphenyl)-1-methyl-quinolin-4-ylidene]methyl]-3-methyl-1,3-benzothiazole, Mango II, POTASSIUM ION Authors: Passalacqua, L.F.M, Ferre-D'Amare, A.R. Deposit date: 2023-09-12 Release date: 2024-03-27 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structure of Mango II aptamer bound to T01-6A To Be Published
8U5J	Structure of Mango III variant aptamer bound to T01-07M-B Descriptor: 2-[(E)-(1,7-dimethylquinolin-4(1H)-ylidene)methyl]-3-{2,16-dioxo-20-[(3aR,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-6,9,12-trioxa-3,15-diazaicosan-1-yl}-1,3-benzothiazol-3-ium, DIMETHYL SULFOXIDE, Mango III variant, ... Authors: Passalacqua, L.F.M, Ferre-D'Amare, A.R. Deposit date: 2023-09-12 Release date: 2024-03-27 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Structure of Mango III variant aptamer bound to T01-07M-B To Be Published
8U5H	Cryo-EM structure of human DNMT3A UDR bound to H2AK119ub1-modified nucleosome Descriptor: DNA (cytosine-5)-methyltransferase 3A, Histone H2A, Histone H2B 1.1, ... Authors: Chen, X, Song, J. Deposit date: 2023-09-12 Release date: 2024-06-12 Method: ELECTRON MICROSCOPY (3.23 Å) Cite: Cryo-EM structure of human DNMT3A N-terminal domain bound to H2AK119Ub nucleosome To Be Published
8U5G	Crystal structure of the co-expressed SDS22:PP1:I3 complex Descriptor: E3 ubiquitin-protein ligase PPP1R11, FE (III) ION, PHOSPHATE ION, ... Authors: Choy, M.S, Peti, W, Page, R. Deposit date: 2023-09-12 Release date: 2023-12-06 Last modified: 2024-01-03 Method: X-RAY DIFFRACTION (3.2 Å) Cite: The SDS22:PP1:I3 complex: SDS22 binding to PP1 loosens the active site metal to prime metal exchange. J.Biol.Chem., 300, 2023
8U5F	Crystal Structure of Trypsinized Clostridium perfringens Enterotoxin Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, Heat-labile enterotoxin B chain, ... Authors: Kapoor, S, Ogbu, C.P, Vecchio, A.J. Deposit date: 2023-09-12 Release date: 2023-09-27 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.32 Å) Cite: Structural Basis of Clostridium perfringens Enterotoxin Activation and Oligomerization by Trypsin. Toxins, 15, 2023
8U5E	Crystal Structure of C-terminal domain of Clostridium perfringens Enterotoxin in Space Group P 21 21 21 Descriptor: ACETATE ION, GLYCEROL, Heat-labile enterotoxin B chain, ... Authors: Kapoor, S, Vecchio, A.J. Deposit date: 2023-09-12 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Structural Basis of Clostridium perfringens Enterotoxin Activation and Oligomerization by Trypsin. Toxins, 15, 2023
8U5D	Crystal Structure of C-terminal domain of Clostridium perfringens Enterotoxin in Space Group P 41 21 2 Descriptor: ACETATE ION, GLYCEROL, Heat-labile enterotoxin B chain, ... Authors: Kapoor, S, Vecchio, A.J. Deposit date: 2023-09-12 Release date: 2023-12-20 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Structural Basis of Clostridium perfringens Enterotoxin Activation and Oligomerization by Trypsin. Toxins, 15, 2023
8U5B	Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain and sFab COP-1 Descriptor: COP-1 sFab Heavy Chain, COP-1 sFab Light Chain, Claudin-4, ... Authors: Vecchio, A.J. Deposit date: 2023-09-12 Release date: 2023-09-27 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (5.3 Å) Cite: Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment. Commun Biol, 7, 2024
8U5A	Improving protein expression, stability, and function with ProteinMPNN Descriptor: Designed myoglobin, PROTOPORPHYRIN IX CONTAINING FE Authors: Kalvet, I, Bera, A.K, Baker, D. Deposit date: 2023-09-12 Release date: 2024-01-17 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2 Å) Cite: Improving Protein Expression, Stability, and Function with ProteinMPNN. J.Am.Chem.Soc., 146, 2024
8U55	Crystal structure of Enterococcus faecium EnGen25 Penicillin-binding protein 5 (PBP5) Descriptor: Penicillin-binding protein 5 Authors: Pemberton, O.A, Shamoo, Y. Deposit date: 2023-09-12 Release date: 2024-02-07 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structure of Enterococcus faecium EnGen25 Penicillin-binding protein 5 (PBP5) To Be Published
8U53	Mechanically activated ion channel OSCA3.1 in nanodiscs Descriptor: 1-PALMITOYL-2-LINOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CSC1-like protein ERD4, PALMITIC ACID, ... Authors: Jojoa-Cruz, S, Lee, W.H, Ward, A.B. Deposit date: 2023-09-12 Release date: 2024-06-05 Method: ELECTRON MICROSCOPY (2.6 Å) Cite: Structure-guided mutagenesis of OSCAs reveals differential activation to mechanical stimuli. Elife, 12, 2024
8U51	Klebsiella pneumoniae SUMO-loaded encapsulin shell Descriptor: Klebsiella pneumoniae family 1 encapsulin shell, SUMO-targeting peptide fusion protein Authors: Andreas, M.P, Jones, J.A, Giessen, T.W. Deposit date: 2023-09-11 Release date: 2024-04-24 Method: ELECTRON MICROSCOPY (2.41 Å) Cite: Structural basis for peroxidase encapsulation inside the encapsulin from the Gram-negative pathogen Klebsiella pneumoniae. Nat Commun, 15, 2024
8U50	Klebsiella pneumoniae DyP peroxidase-loaded encapsulin shell Descriptor: Klebsiella pneumoniae family 1 encapsulin shell Authors: Andreas, M.P, Jones, J.A, Giessen, T.W. Deposit date: 2023-09-11 Release date: 2024-04-24 Method: ELECTRON MICROSCOPY (2.52 Å) Cite: Structural basis for peroxidase encapsulation inside the encapsulin from the Gram-negative pathogen Klebsiella pneumoniae. Nat Commun, 15, 2024
8U4Z	Klebsiella pneumoniae encapsulin-associated DyP peroxidase Descriptor: Family 1 encapsulin-associated DyP peroxidase, Mesoheme Authors: Andreas, M.P, Jones, J.A, Giessen, T.W. Deposit date: 2023-09-11 Release date: 2024-04-24 Method: ELECTRON MICROSCOPY (2.39 Å) Cite: Structural basis for peroxidase encapsulation inside the encapsulin from the Gram-negative pathogen Klebsiella pneumoniae. Nat Commun, 15, 2024
8U4W	The crystal structure of a helical domain deleted PARP1 in complex with isoindolinone based inhibitor. Descriptor: (4M)-4-(2-{4-[(3S)-1-acetylpiperidine-3-carbonyl]piperazine-1-carbonyl}-1-benzofuran-7-yl)-1H-isoindol-1-one, Poly [ADP-ribose] polymerase 1, processed C-terminus Authors: Marcotte, D.J. Deposit date: 2023-09-11 Release date: 2024-03-27 Last modified: 2024-06-26 Method: X-RAY DIFFRACTION (3.02 Å) Cite: Discovery of Potent Isoindolinone Inhibitors that Target an Active Conformation of PARP1 Using DNA-Encoded Libraries. Chemmedchem, 19, 2024
8U4V	Cryo-EM structure of human claudin-4 complex with Clostridium perfringens enterotoxin C-terminal domain, sFab COP-1, and Nanobody Descriptor: Anti-fab nanobody, COP-1 sFab Heavy Chain, COP-1 sFab Light Chain, ... Authors: Vecchio, A.J. Deposit date: 2023-09-11 Release date: 2023-10-25 Last modified: 2024-07-03 Method: ELECTRON MICROSCOPY (2.99 Å) Cite: Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment. Commun Biol, 7, 2024
8U4U	Crystal structure of 53BP1 tandem Tudor domain homodimer engineered with two disulfide bridges Descriptor: TP53-binding protein 1 Authors: Cui, G, Botuyan, M.V, Thompson, J.R, Mer, G. Deposit date: 2023-09-11 Release date: 2023-09-20 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (3.79 Å) Cite: An autoinhibited state of 53BP1 revealed by small molecule antagonists and protein engineering. Nat Commun, 14, 2023
8U4T	Structure of tetrameric CXCR4 in complex with REGN7663 Fab Descriptor: (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, C-X-C chemokine receptor type 4, CHOLESTEROL, ... Authors: Saotome, K, McGoldrick, L.L, Franklin, M.C. Deposit date: 2023-09-11 Release date: 2024-03-13 Method: ELECTRON MICROSCOPY (3.38 Å) Cite: Structural insights into CXCR4 modulation and oligomerization Biorxiv, 2024
8U4S	Structure of trimeric CXCR4 in complex with REGN7663 Fab Descriptor: (2R)-1-(hexadecanoyloxy)-3-(phosphonooxy)propan-2-yl (9Z)-octadec-9-enoate, C-X-C chemokine receptor type 4, CHOLESTEROL, ... Authors: Saotome, K, McGoldrick, L.L, Franklin, M.C. Deposit date: 2023-09-11 Release date: 2024-03-13 Method: ELECTRON MICROSCOPY (3.35 Å) Cite: Structural insights into CXCR4 modulation and oligomerization Biorxiv, 2024
8U4R	Structure of REGN7663-Fab bound CXCR4 Descriptor: C-X-C chemokine receptor type 4, CHOLESTEROL, REGN7663 Fab heavy chain, ... Authors: Saotome, K, McGoldrick, L.L, Franklin, M.C. Deposit date: 2023-09-11 Release date: 2024-03-13 Method: ELECTRON MICROSCOPY (3.1 Å) Cite: Structural insights into CXCR4 modulation and oligomerization Biorxiv, 2024

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