1PVH
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![BU of 1pvh by Molmil](/molmil-images/mine/1pvh) | Crystal structure of leukemia inhibitory factor in complex with gp130 | Descriptor: | IODIDE ION, Interleukin-6 receptor beta chain, Leukemia inhibitory factor | Authors: | Boulanger, M.J, Bankovich, A.J, Kortemme, T, Baker, D, Garcia, K.C. | Deposit date: | 2003-06-27 | Release date: | 2003-10-14 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Convergent mechanisms for recognition of divergent cytokines by the shared signaling receptor gp130. Mol.Cell, 12, 2003
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1TDQ
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![BU of 1tdq by Molmil](/molmil-images/mine/1tdq) | Structural basis for the interactions between tenascins and the C-type lectin domains from lecticans: evidence for a cross-linking role for tenascins | Descriptor: | Aggrecan core protein, CALCIUM ION, Tenascin-R | Authors: | Lundell, A, Olin, A.I, Moergelin, M, al-Karadaghi, S, Aspberg, A, Logan, D.T. | Deposit date: | 2004-05-24 | Release date: | 2004-08-31 | Last modified: | 2021-03-31 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis for interactions between tenascins and lectican C-type lectin domains: evidence for a crosslinking role for tenascins Structure, 12, 2004
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2Q7N
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![BU of 2q7n by Molmil](/molmil-images/mine/2q7n) | Crystal structure of Leukemia inhibitory factor in complex with LIF receptor (domains 1-5) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Huyton, T, Zhang, J.G, Nicola, N.A, Garrett, T.P.J. | Deposit date: | 2007-06-07 | Release date: | 2007-07-31 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptor. Proc.Natl.Acad.Sci.USA, 104, 2007
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2JIX
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![BU of 2jix by Molmil](/molmil-images/mine/2jix) | Crystal structure of ABT-007 FAB fragment with the soluble domain of EPO receptor | Descriptor: | ABT-007 FAB FRAGMENT, ERYTHROPOIETIN RECEPTOR | Authors: | Liu, Z, Stoll, V.S, DeVries, P, Jakob, C.G, Xie, N, Simmer, R.L, Lacy, S.E, Egan, D.A, Harlan, J.E, Lesniewski, R.R, Reilly, E.B. | Deposit date: | 2007-07-02 | Release date: | 2007-07-10 | Last modified: | 2020-03-18 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | A Potent Erythropoietin-Mimicking Human Antibody Interacts Through a Novel Binding Site. Blood, 110, 2007
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2UVE
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![BU of 2uve by Molmil](/molmil-images/mine/2uve) | |
2UVF
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![BU of 2uvf by Molmil](/molmil-images/mine/2uvf) | |
2JLL
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![BU of 2jll by Molmil](/molmil-images/mine/2jll) | Crystal structure of NCAM2 IgIV-FN3II | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | Authors: | Kulahin, N, Rasmussen, K, Kristensen, O, Kastrup, J, Berezin, V, Bock, E, Walmod, P, Gajhede, M. | Deposit date: | 2008-09-10 | Release date: | 2009-11-17 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural Model and Trans-Interaction of the Entire Ectodomain of the Olfactory Cell Adhesion Molecule. Structure, 19, 2011
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2V5Y
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![BU of 2v5y by Molmil](/molmil-images/mine/2v5y) | Crystal structure of the receptor protein tyrosine phosphatase mu ectodomain | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE MU, SODIUM ION | Authors: | Aricescu, A.R, Siebold, C, Choudhuri, K, Chang, V.T, Lu, W, Davis, S.J, van der Merwe, P.A, Jones, E.Y. | Deposit date: | 2007-07-11 | Release date: | 2007-09-11 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure of a Tyrosine Phosphatase Adhesive Interaction Reveals a Spacer-Clamp Mechanism. Science, 317, 2007
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2NZI
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![BU of 2nzi by Molmil](/molmil-images/mine/2nzi) | |
4M4R
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![BU of 4m4r by Molmil](/molmil-images/mine/4m4r) | Epha4 ectodomain complex with ephrin a5 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-A receptor 4, ... | Authors: | Xu, K, Tsvetkova-Robev, D, Xu, Y, Goldgur, Y, Chan, Y.-P, Himanen, J.P, Nikolov, D.B. | Deposit date: | 2013-08-07 | Release date: | 2013-10-30 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.13 Å) | Cite: | Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5. Proc.Natl.Acad.Sci.USA, 110, 2013
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2OCF
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![BU of 2ocf by Molmil](/molmil-images/mine/2ocf) | Human estrogen receptor alpha ligand-binding domain in complex with estradiol and the E2#23 FN3 monobody | Descriptor: | ESTRADIOL, Estrogen receptor, Fibronectin | Authors: | Rajan, S.S, Kuruvilla, S.M, Sharma, S.K, Kim, Y, Huang, J, Koide, A, Koide, S, Joachimiak, A, Greene, G.L. | Deposit date: | 2006-12-20 | Release date: | 2007-11-06 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Probing protein conformational changes in living cells by using designer binding proteins: application to the estrogen receptor. Proc.Natl.Acad.Sci.USA, 99, 2002
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4Y5Y
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![BU of 4y5y by Molmil](/molmil-images/mine/4y5y) | Diabody 330 complex with EpoR | Descriptor: | Erythropoietin receptor, GLYCEROL, diabody 330 VH domain, ... | Authors: | Moraga, I, Guo, F, Ozkan, E, Jude, K.M, Garcia, K.C. | Deposit date: | 2015-02-12 | Release date: | 2015-03-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands. Cell, 160, 2015
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3L5H
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![BU of 3l5h by Molmil](/molmil-images/mine/3l5h) | Crystal structure of the full ectodomain of human gp130: New insights into the molecular assembly of receptor complexes | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-6 receptor subunit beta, SULFATE ION, ... | Authors: | Xu, Y, Garrett, T.P.J, Zhang, J.G. | Deposit date: | 2009-12-21 | Release date: | 2010-05-19 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexes. J.Biol.Chem., 285, 2010
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4Y5X
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![BU of 4y5x by Molmil](/molmil-images/mine/4y5x) | Diabody 305 complex with EpoR | Descriptor: | CITRATE ANION, DI(HYDROXYETHYL)ETHER, Erythropoietin receptor, ... | Authors: | Moraga, I, Guo, F, Ozkan, E, Jude, K.M, Garcia, K.C. | Deposit date: | 2015-02-12 | Release date: | 2015-03-18 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (3.15 Å) | Cite: | Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands. Cell, 160, 2015
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4YH7
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![BU of 4yh7 by Molmil](/molmil-images/mine/4yh7) | Crystal structure of PTPdelta ectodomain in complex with IL1RAPL1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 receptor accessory protein-like 1, ... | Authors: | Yamagata, A, Fukai, S. | Deposit date: | 2015-02-27 | Release date: | 2015-05-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (4.4 Å) | Cite: | Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation. Nat Commun, 6, 2015
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4Y61
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![BU of 4y61 by Molmil](/molmil-images/mine/4y61) | Crystal structure of the complex between Slitrk2 LRR1 and PTP delta Ig1-Fn1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor-type tyrosine-protein phosphatase delta, SLIT and NTRK-like protein 2 | Authors: | Yamgata, A, Sato, Y, Goto-Ito, S, Uemura, T, Maeda, A, Shiroshima, T, Yoshida, T, Fukai, S. | Deposit date: | 2015-02-12 | Release date: | 2015-06-03 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.358 Å) | Cite: | Structure of Slitrk2-PTP delta complex reveals mechanisms for splicing-dependent trans-synaptic adhesion. Sci Rep, 5, 2015
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4Y5V
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![BU of 4y5v by Molmil](/molmil-images/mine/4y5v) | Diabody 305 complex with EpoR | Descriptor: | DI(HYDROXYETHYL)ETHER, Diabody 305 VL domain, Erythropoietin receptor, ... | Authors: | Moraga, I, Guo, F, Ozkan, E, Jude, K.M, Garcia, K.C. | Deposit date: | 2015-02-12 | Release date: | 2015-04-29 | Method: | X-RAY DIFFRACTION (2.604 Å) | Cite: | Tuning Cytokine Receptor Signaling by Re-orienting Dimer Geometry with Surrogate Ligands. Cell, 160, 2015
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4YFG
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![BU of 4yfg by Molmil](/molmil-images/mine/4yfg) | Crystal structure of PTP delta meA3/meB minus variant Ig1-Fn1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Receptor-type tyrosine-protein phosphatase delta | Authors: | Yamagata, A, Fukai, S. | Deposit date: | 2015-02-25 | Release date: | 2015-05-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.491 Å) | Cite: | Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation. Nat Commun, 6, 2015
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4YFD
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![BU of 4yfd by Molmil](/molmil-images/mine/4yfd) | Crystal structure PTP delta Ig1-Fn2 in complex with IL-1RAcP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-1 receptor accessory protein, Receptor-type tyrosine-protein phosphatase delta | Authors: | Yamagata, A, Fukai, S. | Deposit date: | 2015-02-25 | Release date: | 2015-05-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.253 Å) | Cite: | Mechanisms of splicing-dependent trans-synaptic adhesion by PTP delta-IL1RAPL1/IL-1RAcP for synaptic differentiation. Nat Commun, 6, 2015
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4ZXB
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![BU of 4zxb by Molmil](/molmil-images/mine/4zxb) | Structure of the human insulin receptor ectodomain, IRDeltabeta construct, in complex with four Fab molecules | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Croll, T, Smith, B.J, Margetts, M.B, Whittaker, J, Weiss, M.A, Ward, C.W, Lawrence, M.C. | Deposit date: | 2015-05-20 | Release date: | 2016-02-24 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain. Structure, 24, 2016
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3MTR
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![BU of 3mtr by Molmil](/molmil-images/mine/3mtr) | Crystal structure of the Ig5-FN1 tandem of human NCAM | Descriptor: | Neural cell adhesion molecule 1, SULFATE ION | Authors: | Lavie, A, Foley, D.A. | Deposit date: | 2010-04-30 | Release date: | 2010-06-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure and mutagenesis of neural cell adhesion molecule domains: evidence for flexibility in the placement of polysialic acid attachment sites J.Biol.Chem., 285, 2010
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3MX0
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![BU of 3mx0 by Molmil](/molmil-images/mine/3mx0) | Crystal Structure of EphA2 ectodomain in complex with ephrin-A5 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ephrin type-A receptor 2, ... | Authors: | Himanen, J.P, Yermekbayeva, L, Janes, P.W, Walker, J.R, Xu, K, Atapattu, L, Rajashankar, K.R, Mensinga, A, Lackmann, M, Nikolov, D.B, Dhe-Paganon, S. | Deposit date: | 2010-05-06 | Release date: | 2010-06-30 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (3.506 Å) | Cite: | Architecture of Eph receptor clusters. Proc.Natl.Acad.Sci.USA, 107, 2010
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3N1Q
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![BU of 3n1q by Molmil](/molmil-images/mine/3n1q) | Crystal Structure of DhhN bound to CDOFn3 | Descriptor: | CALCIUM ION, Cell adhesion molecule-related/down-regulated by oncogenes, Desert hedgehog protein, ... | Authors: | Kavran, J.M, Leahy, D.J. | Deposit date: | 2010-05-16 | Release date: | 2010-06-02 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. J.Biol.Chem., 285, 2010
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3N1M
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![BU of 3n1m by Molmil](/molmil-images/mine/3n1m) | Crystal Structure of IhhN bound to BOCFn3 | Descriptor: | Brother of CDO, CALCIUM ION, Indian hedgehog protein, ... | Authors: | Kavran, J.M, Leahy, D.J. | Deposit date: | 2010-05-15 | Release date: | 2010-06-02 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.69 Å) | Cite: | All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. J.Biol.Chem., 285, 2010
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3N1F
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![BU of 3n1f by Molmil](/molmil-images/mine/3n1f) | Crystal Structure of IhhN bound to CDOFn3 | Descriptor: | CALCIUM ION, Cell adhesion molecule-related/down-regulated by oncogenes, Indian hedgehog protein, ... | Authors: | Kavran, J.M, Leahy, D.J. | Deposit date: | 2010-05-15 | Release date: | 2010-06-02 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | All mammalian Hedgehog proteins interact with cell adhesion molecule, down-regulated by oncogenes (CDO) and brother of CDO (BOC) in a conserved manner. J.Biol.Chem., 285, 2010
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