4H2G
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![BU of 4h2g by Molmil](/molmil-images/mine/4h2g) | Human ecto-5'-nucleotidase (CD73): crystal form II (open) in complex with adenosine | Descriptor: | 5'-nucleotidase, ADENOSINE, CALCIUM ION, ... | Authors: | Straeter, N, Knapp, K.M, Zebisch, M, Pippel, J. | Deposit date: | 2012-09-12 | Release date: | 2012-11-28 | Last modified: | 2012-12-26 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling. Structure, 20, 2012
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4HD0
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![BU of 4hd0 by Molmil](/molmil-images/mine/4hd0) | Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair | Descriptor: | DNA double-strand break repair protein Mre11, MANGANESE (II) ION | Authors: | Limbo, O, Moiani, D, Kertokalio, A, Wyman, C, Tainer, J.A, Russell, P. | Deposit date: | 2012-10-01 | Release date: | 2012-10-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mre11 ATLD17/18 mutation retains Tel1/ATM activity but blocks DNA double-strand break repair. Nucleic Acids Res., 40, 2012
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3V4Y
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![BU of 3v4y by Molmil](/molmil-images/mine/3v4y) | Crystal Structure of the first Nuclear PP1 holoenzyme | Descriptor: | GLYCEROL, MANGANESE (II) ION, Nuclear inhibitor of protein phosphatase 1, ... | Authors: | Page, R, Peti, W, O'Connell, N.E, Nichols, S. | Deposit date: | 2011-12-15 | Release date: | 2012-10-31 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.098 Å) | Cite: | The Molecular Basis for Substrate Specificity of the Nuclear NIPP1:PP1 Holoenzyme. Structure, 20, 2012
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4H1S
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![BU of 4h1s by Molmil](/molmil-images/mine/4h1s) | Crystal Structure of a Truncated Soluble form of Human CD73 with Ecto-5'-Nucleotidase activity | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-nucleotidase, PHOSPHATE ION, ... | Authors: | Heuts, D.P, Weissenborn, M.J, Olkhov, R.V, Shaw, A.M, Levy, C.W, Scrutton, N.S. | Deposit date: | 2012-09-11 | Release date: | 2012-10-03 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of a soluble form of human CD73 with ecto-5'-nucleotidase activity. Chembiochem, 13, 2012
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4G9J
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![BU of 4g9j by Molmil](/molmil-images/mine/4g9j) | Protein Ser/Thr phosphatase-1 in complex with cell-permeable peptide | Descriptor: | MANGANESE (II) ION, Serine/threonine-protein phosphatase PP1-alpha catalytic subunit, synthetic peptide | Authors: | Sukackaite, R, Chatterjee, J, Beullens, M, Bollen, M, Koehn, M, Hart, D.J. | Deposit date: | 2012-07-24 | Release date: | 2012-09-19 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Development of a Peptide that Selectively Activates Protein Phosphatase-1 in Living Cells. Angew.Chem.Int.Ed.Engl., 51, 2012
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4DT2
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![BU of 4dt2 by Molmil](/molmil-images/mine/4dt2) | Crystal structure of red kidney bean purple acid phosphatase in complex with Maybridge fragment CC27209 | Descriptor: | (2,2-dimethyl-2,3-dihydro-1-benzofuran-7-yl)methanol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Feder, D, Hussein, W.M, Clayton, D.J, Kan, M, Schenk, G, McGeary, R.P, Guddat, L.W. | Deposit date: | 2012-02-20 | Release date: | 2012-09-19 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chem.Biol.Drug Des., 80, 2012
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4DSY
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![BU of 4dsy by Molmil](/molmil-images/mine/4dsy) | Crystal structure of red kidney bean purple acid phosphatase in complex with Maybridge fragment CC24201 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-phenylpyridine-3-carboxylic acid, ... | Authors: | Feder, D, Hussein, W.M, Clayton, D.J, Kan, M, Schenk, G, McGeary, R.P, Guddat, L.W. | Deposit date: | 2012-02-20 | Release date: | 2012-09-19 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Identification of purple acid phosphatase inhibitors by fragment-based screening: promising new leads for osteoporosis therapeutics. Chem.Biol.Drug Des., 80, 2012
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4FCX
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![BU of 4fcx by Molmil](/molmil-images/mine/4fcx) | S.pombe Mre11 apoenzym | Descriptor: | DNA repair protein rad32, MANGANESE (II) ION | Authors: | Schiller, C.B, Lammens, K, Hopfner, K.P. | Deposit date: | 2012-05-25 | Release date: | 2012-06-20 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling. Nat.Struct.Mol.Biol., 19, 2012
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4FBW
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![BU of 4fbw by Molmil](/molmil-images/mine/4fbw) | |
4FBQ
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![BU of 4fbq by Molmil](/molmil-images/mine/4fbq) | |
4FBK
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![BU of 4fbk by Molmil](/molmil-images/mine/4fbk) | Crystal structure of a covalently fused Nbs1-Mre11 complex with one manganese ion per active site | Descriptor: | DNA repair and telomere maintenance protein nbs1,DNA repair protein rad32 CHIMERIC PROTEIN, MANGANESE (II) ION, SULFATE ION | Authors: | Schiller, C.B, Lammens, K, Hopfner, K.P. | Deposit date: | 2012-05-23 | Release date: | 2012-06-20 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.379 Å) | Cite: | Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling. Nat.Struct.Mol.Biol., 19, 2012
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3TGH
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![BU of 3tgh by Molmil](/molmil-images/mine/3tgh) | GAP50 the anchor in the inner membrane complex of Plasmodium | Descriptor: | COBALT (II) ION, DIMETHYL SULFOXIDE, Glideosome-associated protein 50, ... | Authors: | Bosch, J, Paige, M.H, Vaidya, A, Bergman, L, Hol, W.G.J. | Deposit date: | 2011-08-17 | Release date: | 2012-03-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum. J.Struct.Biol., 178, 2012
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3ZTV
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![BU of 3ztv by Molmil](/molmil-images/mine/3ztv) | Structure of Haemophilus influenzae NAD nucleotidase (NadN) | Descriptor: | ADENOSINE, GLYCEROL, NAD NUCLEOTIDASE, ... | Authors: | Garavaglia, S, Bruzzone, S, Cassani, C, Canella, L, Allegrone, G, Sturla, L, Mannino, E, Millo, E, De Flora, A, Rizzi, M. | Deposit date: | 2011-07-12 | Release date: | 2011-12-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | The High-Resolution Crystal Structure of Periplasmic Haemophilus Influenzae Nad Nucleotidase Reveals a Novel Enzymatic Function of Human Cd73 Related to Nad Metabolism. Biochem.J., 441, 2012
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3ZU0
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![BU of 3zu0 by Molmil](/molmil-images/mine/3zu0) | Structure of Haemophilus influenzae NAD nucleotidase (NadN) | Descriptor: | NAD NUCLEOTIDASE, PHOSPHATE ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... | Authors: | Garavaglia, S, Bruzzone, S, Cassani, C, Canella, L, Allegrone, G, Sturla, L, Mannino, E, Millo, E, De Flora, A, Rizzi, M. | Deposit date: | 2011-07-13 | Release date: | 2011-12-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | The High-Resolution Crystal Structure of Periplasmic Haemophilus Influenzae Nad Nucleotidase Reveals a Novel Enzymatic Function of Human Cd73 Related to Nad Metabolism. Biochem.J., 441, 2012
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3T1I
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![BU of 3t1i by Molmil](/molmil-images/mine/3t1i) | Crystal Structure of Human Mre11: Understanding Tumorigenic Mutations | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Double-strand break repair protein MRE11A, GLYCEROL, ... | Authors: | Park, Y.B, Chae, J, Kim, Y, Cho, Y. | Deposit date: | 2011-07-22 | Release date: | 2011-11-30 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of human mre11: understanding tumorigenic mutations Structure, 19, 2011
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3THN
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![BU of 3thn by Molmil](/molmil-images/mine/3thn) | Crystal structure of Mre11 core with manganese | Descriptor: | Exonuclease, putative, MANGANESE (II) ION, ... | Authors: | Moeckel, C, Lammens, K. | Deposit date: | 2011-08-19 | Release date: | 2011-10-12 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.811 Å) | Cite: | ATP driven structural changes of the bacterial Mre11:Rad50 catalytic head complex. Nucleic Acids Res., 40, 2012
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3THO
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![BU of 3tho by Molmil](/molmil-images/mine/3tho) | |
3RL3
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![BU of 3rl3 by Molmil](/molmil-images/mine/3rl3) | Rat metallophosphodiesterase MPPED2 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, GUANOSINE-5'-MONOPHOSPHATE, ... | Authors: | Podobnik, M, Dermol, U. | Deposit date: | 2011-04-19 | Release date: | 2011-08-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Unique utilization of a phosphoprotein phosphatase fold by a mammalian phosphodiesterase associated with WAGR syndrome. J.Mol.Biol., 412, 2011
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3RL4
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![BU of 3rl4 by Molmil](/molmil-images/mine/3rl4) | Rat metallophosphodiesterase MPPED2 G252H Mutant | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, GUANOSINE-5'-MONOPHOSPHATE, ... | Authors: | Podobnik, M, Dermol, U. | Deposit date: | 2011-04-19 | Release date: | 2011-08-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | Unique utilization of a phosphoprotein phosphatase fold by a mammalian phosphodiesterase associated with WAGR syndrome. J.Mol.Biol., 412, 2011
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3RL5
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![BU of 3rl5 by Molmil](/molmil-images/mine/3rl5) | Rat metallophosphodiesterase MPPED2 H67R Mutant | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Metallophosphoesterase MPPED2, ... | Authors: | Podobnik, M, Dermol, U. | Deposit date: | 2011-04-19 | Release date: | 2011-08-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.26 Å) | Cite: | Unique utilization of a phosphoprotein phosphatase fold by a mammalian phosphodiesterase associated with WAGR syndrome. J.Mol.Biol., 412, 2011
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3AV0
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![BU of 3av0 by Molmil](/molmil-images/mine/3av0) | Crystal structure of Mre11-Rad50 bound to ATP S | Descriptor: | DNA double-strand break repair protein mre11, DNA double-strand break repair rad50 ATPase, GLYCEROL, ... | Authors: | Lim, H.S, Kim, J.S, Cho, Y. | Deposit date: | 2011-02-18 | Release date: | 2011-05-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Crystal Structure of the Mre11-Rad50-ATP S Complex: Understanding the Interplay between Mre11 and Rad50 To be Published
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3AUZ
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![BU of 3auz by Molmil](/molmil-images/mine/3auz) | Crystal structure of Mre11 with manganese | Descriptor: | DNA double-strand break repair protein mre11, GLYCEROL, MANGANESE (II) ION | Authors: | Park, Y.B, Cho, Y. | Deposit date: | 2011-02-18 | Release date: | 2011-05-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.206 Å) | Cite: | Crystal Structure of the Mre11-Rad50-ATP S Complex: Understanding the Interplay between Mre11 and Rad50 To be Published
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3QG5
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![BU of 3qg5 by Molmil](/molmil-images/mine/3qg5) | |
2XMO
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![BU of 2xmo by Molmil](/molmil-images/mine/2xmo) | The crystal structure of Lmo2642 | Descriptor: | CALCIUM ION, FE (III) ION, LMO2642 PROTEIN, ... | Authors: | Jeong, J.H, Kim, Y.G. | Deposit date: | 2010-07-28 | Release date: | 2011-02-23 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural and Functional Analysis of the Lmo2642 Cyclic Nucleotide Phosphodiesterase from Listeria Monocytogenes. Proteins, 79, 2011
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3P71
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![BU of 3p71 by Molmil](/molmil-images/mine/3p71) | Crystal structure of the complex of LCMT-1 and PP2A | Descriptor: | 5'-{[(3S)-3-amino-3-carboxypropyl](ethyl)amino}-5'-deoxyadenosine, DI(HYDROXYETHYL)ETHER, Leucine carboxyl methyltransferase 1, ... | Authors: | Xing, Y, Stanevich, V, Satyshur, K.A, Jiang, L. | Deposit date: | 2010-10-11 | Release date: | 2011-02-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The Structural Basis for Tight Control of PP2A Methylation and Function by LCMT-1. Mol.Cell, 41, 2011
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