PDB: 594 resultsInfo pagesStatus searchChemie searchBIRD

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3OV1	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: FORMIC ACID, GLYCEROL, Growth factor receptor-bound protein 2, ... Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-09-15 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.6 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3S8L	Protein-Ligand Interactions: Thermodynamic Effects Associated with Increasing Hydrophobic Surface Area Descriptor: CHLORIDE ION, GLYCEROL, Growth factor receptor-bound protein 2, ... Authors: Clements, J.H, Stephen, F.M. Deposit date: 2011-05-29 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3S8O	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, SODIUM ION, ... Authors: Clements, J.H, Stephen, F.M. Deposit date: 2011-05-29 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3OVE	Crystal Structure of the Grb2 SH2 Domain in Complex with a pYXN-Derived Tripeptide Descriptor: CHLORIDE ION, Growth factor receptor-bound protein 2, PYAC7CN Authors: Clements, J.H, Martin, S.F. Deposit date: 2010-09-16 Release date: 2011-11-02 Last modified: 2023-12-06 Method: X-RAY DIFFRACTION (1.82 Å) Cite: Protein-ligand interactions: thermodynamic effects associated with increasing nonpolar surface area. J.Am.Chem.Soc., 133, 2011
3T04	Crystal structure of monobody 7c12/abl1 sh2 domain complex Descriptor: GLYCEROL, MONOBODY 7C12, SULFATE ION, ... Authors: Wojcik, J.B, Wyrzucki, A.M, Koide, S. Deposit date: 2011-07-19 Release date: 2011-11-23 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis. Cell(Cambridge,Mass.), 147, 2011
3UF4	Crystal structure of a SH3 and SH2 domains of FYN protein (Proto-concogene Tyrosine-protein kinase Fyn) from Mus musculus at 1.98 A resolution Descriptor: CHLORIDE ION, GLYCEROL, SODIUM ION, ... Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2011-10-31 Release date: 2011-12-07 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.98 Å) Cite: Crystal structure of a SH3 and SH2 domains of FYN protein (Proto-concogene Tyrosine-protein kinase Fyn) from Mus musculus at 1.98 A resolution To be published
3US4	Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution Descriptor: Megakaryocyte-associated tyrosine-protein kinase, SULFATE ION Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2011-11-22 Release date: 2011-12-28 Last modified: 2023-02-01 Method: X-RAY DIFFRACTION (1.5 Å) Cite: Crystal structure of a SH2 domain of a megakaryocyte-associated tyrosine kinase (MATK) from Homo sapiens at 1.50 A resolution To be published
3UYO	Crystal structure of monobody SH13/ABL1 SH2 domain complex Descriptor: Monobody SH13, SULFATE ION, Tyrosine-protein kinase ABL1 Authors: Wojcik, J.B, Koide, A, Koide, S. Deposit date: 2011-12-06 Release date: 2011-12-28 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.83 Å) Cite: Teaching an old scaffold new tricks: monobodies constructed using alternative surfaces of the FN3 scaffold. J.Mol.Biol., 415, 2012
4A55	Crystal structure of p110alpha in complex with iSH2 of p85alpha and the inhibitor PIK-108 Descriptor: PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM, PIK-108 Authors: Hon, W.-C, Berndt, A, Williams, R.L. Deposit date: 2011-10-24 Release date: 2011-12-28 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (3.5 Å) Cite: Regulation of Lipid Binding Underlies the Activation Mechanism of Class Ia Pi3-Kinases. Oncogene, 31, 2012
4D8K	Crystal structure of a SH3-SH2 domains of a lymphocyte-specific protein tyrosine kinase (LCK) from Homo sapiens at 2.36 A resolution Descriptor: GLYCEROL, SULFATE ION, Tyrosine-protein kinase Lck Authors: Joint Center for Structural Genomics (JCSG), Partnership for T-Cell Biology (TCELL) Deposit date: 2012-01-10 Release date: 2012-01-25 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.36 Å) Cite: Crystal structure of a SH3-SH2 domains of a lymphocyte-specific protein tyrosine kinase (LCK) from Homo sapiens at 2.36 A resolution To be published
3S9K	Crystal structure of the Itk SH2 domain. Descriptor: CITRIC ACID, Tyrosine-protein kinase ITK/TSK Authors: Joseph, R.E, Ginder, N.D, Hoy, J.A, Nix, J.C, Fulton, B.D, Honzatko, R.B, Andreotti, A.H. Deposit date: 2011-06-01 Release date: 2012-02-08 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.354 Å) Cite: Structure of the interleukin-2 tyrosine kinase Src homology 2 domain; comparison between X-ray and NMR-derived structures. Acta Crystallogr.,Sect.F, 68, 2012
4E93	Crystal structure of human Feline Sarcoma Viral Oncogene Homologue (v-FES)in complex with TAE684 Descriptor: 5-CHLORO-N-[2-METHOXY-4-[4-(4-METHYLPIPERAZIN-1-YL)PIPERIDIN-1-YL]PHENYL]-N'-(2-PROPAN-2-YLSULFONYLPHENYL)PYRIMIDINE-2,4-DIAMINE, Tyrosine-protein kinase Fes/Fps Authors: Filippakopoulos, P, Salah, E, Miduturu, C.V, Fedorov, O, Cooper, C, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Gray, N.S, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2012-03-20 Release date: 2012-04-18 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.84 Å) Cite: Small-Molecule Inhibitors of the c-Fes Protein-Tyrosine Kinase. Chem.Biol., 19, 2012
2LQW	Solution structure of phosphorylated CRKL Descriptor: Crk-like protein Authors: Jankowski, W, Saleh, T, Kalodimos, C. Deposit date: 2012-03-16 Release date: 2012-05-16 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII. Nat.Chem.Biol., 8, 2012
2LQN	Solution structure of CRKL Descriptor: Crk-like protein Authors: Jankowski, W, Saleh, T, Kalodimos, C. Deposit date: 2012-03-09 Release date: 2012-05-16 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Domain organization differences explain Bcr-Abl's preference for CrkL over CrkII. Nat.Chem.Biol., 8, 2012
4F59	Triple mutant Src SH2 domain Descriptor: Proto-oncogene tyrosine-protein kinase Src Authors: Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. Deposit date: 2012-05-12 Release date: 2012-10-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.71 Å) Cite: Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
4F5A	Triple mutant Src SH2 domain bound to phosphate ion Descriptor: PHOSPHATE ION, Proto-oncogene tyrosine-protein kinase Src Authors: Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. Deposit date: 2012-05-12 Release date: 2012-10-03 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
4F5B	Triple mutant Src SH2 domain bound to phosphotyrosine Descriptor: O-PHOSPHOTYROSINE, Proto-oncogene tyrosine-protein kinase Src Authors: Kaneko, T, Huang, H, Cao, X, Li, C, Voss, C, Sidhu, S.S, Li, S.S. Deposit date: 2012-05-12 Release date: 2012-10-03 Last modified: 2024-03-13 Method: X-RAY DIFFRACTION (1.57 Å) Cite: Superbinder SH2 Domains Act as Antagonists of Cell Signaling. Sci.Signal., 5, 2012
4FBN	Insights into structural integration of the PLCgamma regulatory region and mechanism of autoinhibition and activation based on key roles of SH2 domains Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Authors: Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. Deposit date: 2012-05-23 Release date: 2012-10-31 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.4 Å) Cite: Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation. Structure, 20, 2012
4EY0	Structure of tandem SH2 domains from PLCgamma1 Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 Authors: Cole, A.R, Mas-Droux, C.P, Bunney, T.D, Katan, M. Deposit date: 2012-05-01 Release date: 2012-10-31 Last modified: 2013-06-19 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Structural and Functional Integration of the PLCgamma Interaction Domains Critical for Regulatory Mechanisms and Signaling Deregulation. Structure, 20, 2012
2LNW	Identification and structural basis for a novel interaction between Vav2 and Arap3 Descriptor: Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3, Guanine nucleotide exchange factor VAV2 Authors: Wu, B, Zhang, J, Wu, J, Shi, Y. Deposit date: 2012-01-05 Release date: 2012-11-21 Last modified: 2023-06-14 Method: SOLUTION NMR Cite: Identification and structural basis for a novel interaction between Vav2 and Arap3. J.Struct.Biol., 180, 2012
2LNX	Solution structure of Vav2 SH2 domain Descriptor: Guanine nucleotide exchange factor VAV2 Authors: Wu, B, Zhang, J, Wu, J, Shi, Y. Deposit date: 2012-01-05 Release date: 2012-11-21 Last modified: 2024-05-15 Method: SOLUTION NMR Cite: Identification and structural basis for a novel interaction between Vav2 and Arap3. J.Struct.Biol., 180, 2012
4FL3	Structural and Biophysical Characterization of the Syk Activation Switch Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tyrosine-protein kinase SYK Authors: Graedler, U, Schwarz, D, Dresing, V, Musil, M, Bomke, J, Frech, M, Jaekel, S, Rysiok, T, Mueller-Pompalla, D, Wegener, A. Deposit date: 2012-06-14 Release date: 2012-11-28 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural and biophysical characterization of the syk activation switch. J.Mol.Biol., 425, 2013
4FL2	Structural and Biophysical Characterization of the Syk Activation Switch Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Tyrosine-protein kinase SYK Authors: Graedler, U, Schwarz, D, Dresing, V, Musil, M, Bomke, J, Frech, M, Jaekel, S, Rysiok, T, Mueller-Pompalla, D, Wegener, A. Deposit date: 2012-06-14 Release date: 2012-11-28 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.19 Å) Cite: Structural and biophysical characterization of the syk activation switch. J.Mol.Biol., 425, 2013
4GL9	Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain Descriptor: 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, Interleukin-6 receptor subunit beta, PHOSPHATE ION, ... Authors: Kershaw, N.J, Murphy, J.M, Laktyushin, A, Nicola, N.A, Babon, J.J. Deposit date: 2012-08-14 Release date: 2013-03-06 Last modified: 2018-06-13 Method: X-RAY DIFFRACTION (3.9 Å) Cite: SOCS3 binds specific receptor-JAK complexes to control cytokine signaling by direct kinase inhibition. Nat.Struct.Mol.Biol., 20, 2013
4DGX	LEOPARD Syndrome-Associated SHP2/Y279C mutant Descriptor: Tyrosine-protein phosphatase non-receptor type 11 Authors: Yu, Z.H, Xu, J, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L.N, Liu, S.J, Zhang, Z.Y. Deposit date: 2012-01-27 Release date: 2013-03-06 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations. J.Biol.Chem., 288, 2013

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