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PDB: 127 results

1GZL
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Crystal structure of C14linkmid/IQN17: a cross-linked inhibitor of HIV-1 entry bound to the gp41 hydrophobic pocket
Descriptor: CHLORIDE ION, ENVELOPE GLYCOPROTEIN GP41, FUSION PROTEIN BETWEEN THE HYDROPHOBIC POCKET OF HIV GP41 AND GENERAL CONTROL PROTEIN GCN4-PIQI, ...
Authors:Sia, S.K, Carr, P.A, Cochran, A.G, Malashkevich, V.M, Kim, P.S.
Deposit date:2002-05-23
Release date:2002-10-10
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Short Constrained Peptides that Inhibit HIV-1 Entry
Proc.Natl.Acad.Sci.USA, 99, 2002
5CIL
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BU of 5cil by Molmil
Crystal Structure of non-neutralizing version of 4E10 (WDWD) with epitope bound
Descriptor: ACETATE ION, CHLORIDE ION, FAB 4E10 HEAVY CHAIN, ...
Authors:Caaveiro, J.M.M, Rujas, E, Nieva, J.L, Tsumoto, K.
Deposit date:2015-07-13
Release date:2015-09-23
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Structural and Thermodynamic Basis of Epitope Binding by Neutralizing and Nonneutralizing Forms of the Anti-HIV-1 Antibody 4E10
J.Virol., 89, 2015
5KA6
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BU of 5ka6 by Molmil
HIV-1 gp41 variant Q552R and L555M resistance mutations
Descriptor: Transmembrane protein gp41
Authors:Bhardwaj, A, Khasnis, M.D, Halkidis, K, Root, M.J.
Deposit date:2016-06-01
Release date:2016-12-14
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Receptor Activation of HIV-1 Env Leads to Asymmetric Exposure of the gp41 Trimer.
PLoS Pathog., 12, 2016
1K34
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BU of 1k34 by Molmil
Crystal structure analysis of gp41 core mutant
Descriptor: Transmembrane glycoprotein GP41
Authors:Shu, W, Lu, M.
Deposit date:2001-10-01
Release date:2001-10-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Interhelical interactions in the gp41 core: implications for activation of HIV-1 membrane fusion.
Biochemistry, 41, 2002
6PDS
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BU of 6pds by Molmil
Vaccine-elicited NHP FP-targeting antibody 0PV-a.04 in complex with HIV fusion peptide (residue 512-519)
Descriptor: HIV-1 fusion peptide residue 512-519, SULFATE ION, antibody 0PV-a.04 heavy chain, ...
Authors:Xu, K, Liu, K, Wang, Y, Kwong, P.D.
Deposit date:2019-06-19
Release date:2020-06-24
Method:X-RAY DIFFRACTION (1.893 Å)
Cite:Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
5Z0W
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BU of 5z0w by Molmil
Crystal structure of HIV-1 fusion inhibitor SC29EK complexed with gp41 NHR (N36)
Descriptor: peptide-C, peptide-N
Authors:Liu, Z.X, Qin, B, Cui, S.
Deposit date:2017-12-21
Release date:2018-01-10
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.896 Å)
Cite:Mechanism of HIV-1 Resistance to an Electronically Constrained alpha-Helical Peptide Membrane Fusion Inhibitor
J. Virol., 92, 2018
5CN0
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BU of 5cn0 by Molmil
Artificial HIV fusion inhibitor AP2 fused to the C-terminus of gp41 NHR
Descriptor: DI(HYDROXYETHYL)ETHER, Envelope glycoprotein,AP2, MAGNESIUM ION
Authors:Zhu, Y, Ye, S, Zhang, R.
Deposit date:2015-07-17
Release date:2015-09-16
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy.
Sci Rep, 5, 2015
6UBI
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BU of 6ubi by Molmil
N123-VRC34.05 HIV neutralizing antibody in complex with HIV fusion peptide residue 512-519
Descriptor: HIV fusion peptide 512-519, VRC34.05 heavy chain, VRC34.05 light chain
Authors:Xu, K, Liu, K, Kwong, P.D.
Deposit date:2019-09-11
Release date:2020-03-18
Last modified:2020-04-22
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.
Cell Host Microbe, 27, 2020
6PDU
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BU of 6pdu by Molmil
Vaccine-elicited NHP FP-targeting antibody 13N024-a.01 in complex with HIV fusion peptide (residue 512-519)
Descriptor: HIV-1 fusion peptide residue 512-519, antibody 13N024-a.01, heavy chain, ...
Authors:Xu, K, Liu, K, Wang, Y, Kwong, P.D.
Deposit date:2019-06-19
Release date:2020-06-24
Method:X-RAY DIFFRACTION (1.953 Å)
Cite:Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
6O3L
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BU of 6o3l by Molmil
Crystal structure of the Fab fragment of the human HIV-1 neutralizing antibody PGZL1.H4K3 in complex with its MPER peptide epitope (region 671-683 of HIV-1 gp41).
Descriptor: GLYCEROL, MPER peptide, region 671-683 of HIV-1 gp41, ...
Authors:Irimia, A, Wilson, I.A.
Deposit date:2019-02-26
Release date:2019-12-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:An MPER antibody neutralizes HIV-1 using germline features shared among donors.
Nat Commun, 10, 2019
6MQC
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BU of 6mqc by Molmil
Vaccine-elicited NHP FP-targeting neutralizing antibody 0PV-c.01 in complex with FP (residue 512-519)
Descriptor: 0PV-C.01 antibody Fab heavy chain, 0PV-C.01 antibody Fab light chain, HIV fusion peptide residue 512-519
Authors:Xu, K, Wang, Y, Kwong, P.D.
Deposit date:2018-10-09
Release date:2019-07-31
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization.
Cell, 178, 2019
7N08
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BU of 7n08 by Molmil
Crystal structure of the 3D6 antibody fragment bound to the HIV-1 gp41 immunodominant region
Descriptor: Fab 3D6 heavy chain, Fab 3D6 light chain, HIV-1 gp41 immunodominant region
Authors:Cook, J.D, Lee, J.E.
Deposit date:2021-05-25
Release date:2022-03-30
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Conformational plasticity of the HIV-1 gp41 immunodominant region is recognized by multiple non-neutralizing antibodies.
Commun Biol, 5, 2022
8F3B
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BU of 8f3b by Molmil
HIV-1 gp41 coiled-coil pocket IQN22
Descriptor: IQN22
Authors:Bruun, T.U.J, Tang, S, Fernandez, D, Kim, P.S.
Deposit date:2022-11-09
Release date:2023-03-08
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-guided stabilization improves the ability of the HIV-1 gp41 hydrophobic pocket to elicit neutralizing antibodies.
J.Biol.Chem., 299, 2023
5YC0
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BU of 5yc0 by Molmil
Crystal structure of LP-46/N44
Descriptor: Envelope glycoprotein, LP-46
Authors:Zhang, X, Wang, X, He, Y.
Deposit date:2017-09-05
Release date:2018-02-14
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Exceptional potency and structural basis of a T1249-derived lipopeptide fusion inhibitor against HIV-1, HIV-2, and simian immunodeficiency virus
J. Biol. Chem., 293, 2018
2X7R
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BU of 2x7r by Molmil
Crystal structure of a late fusion intermediate of HIV-1 gp41
Descriptor: CHLORIDE ION, SODIUM ION, TRANSMEMBRANE PROTEIN GP41
Authors:Natrajan, G, Buzon, V, Weissenhorn, W.
Deposit date:2010-03-03
Release date:2010-05-26
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of HIV-1 Gp41 Including Both Fusion Peptide and Membrane Proximal External Regions.
Plos Pathog., 6, 2010
1AIK
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BU of 1aik by Molmil
HIV GP41 CORE STRUCTURE
Descriptor: HIV-1 GP41 GLYCOPROTEIN
Authors:Chan, D.C, Fass, D, Berger, J.M, Kim, P.S.
Deposit date:1997-04-20
Release date:1997-06-16
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:Core structure of gp41 from the HIV envelope glycoprotein.
Cell(Cambridge,Mass.), 89, 1997
2CMR
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BU of 2cmr by Molmil
Crystal structure of the HIV-1 neutralizing antibody D5 Fab bound to the gp41 inner-core mimetic 5-helix
Descriptor: D5, GLYCEROL, TRANSMEMBRANE GLYCOPROTEIN
Authors:Luftig, M.A, Mattu, M, Di Giovine, P, Geleziunas, R, Hrin, R, Barbato, G, Bianchi, E, Miller, M.D, Pessi, A, Carfi, A.
Deposit date:2006-05-11
Release date:2006-10-16
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for HIV-1 Neutralization by a Gp41 Fusion Intermediate-Directed Antibody
Nat.Struct.Mol.Biol., 13, 2006
1DLB
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BU of 1dlb by Molmil
HELICAL INTERACTIONS IN THE HIV-1 GP41 CORE REVEALS STRUCTURAL BASIS FOR THE INHIBITORY ACTIVITY OF GP41 PEPTIDES
Descriptor: HIV-1 ENVELOPE GLYCOPROTEIN GP41
Authors:Shu, W, Liu, J, Ji, H, Rading, L, Jiang, S, Lu, M.
Deposit date:1999-12-09
Release date:1999-12-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Helical interactions in the HIV-1 gp41 core reveal structural basis for the inhibitory activity of gp41 peptides.
Biochemistry, 39, 2000
6PEF
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BU of 6pef by Molmil
Vaccine-elicited NHP FP-targeting antibody DF2F-a.01 in complex with HIV fusion peptide (residue 512-519)
Descriptor: HIV fusion peptide residue 512-519, antibody DF2F-a.01 heavy chain, antibody DF2F-a.01 light chain
Authors:Xu, K, Liu, K, Wang, Y, Kwong, P.D.
Deposit date:2019-06-20
Release date:2020-06-24
Method:X-RAY DIFFRACTION (2.004 Å)
Cite:Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
5YB3
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BU of 5yb3 by Molmil
Crystal structure of HP23L/N36
Descriptor: Envelope glycoprotein, HP23L
Authors:Zhang, X, Wang, X, He, Y.
Deposit date:2017-09-03
Release date:2018-02-28
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.043 Å)
Cite:Structural Insights into the Mechanisms of Action of Short-Peptide HIV-1 Fusion Inhibitors Targeting the Gp41 Pocket
Front Cell Infect Microbiol, 8, 2018
3D0V
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BU of 3d0v by Molmil
Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide LLELDKWASLW
Descriptor: 2F5 Fab heavy chain, 2F5 Fab light chain, gp41 peptide LLELDKWASLW
Authors:Bryson, S, Julien, J.P, Pai, E.F.
Deposit date:2008-05-02
Release date:2008-07-29
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site.
J.Mol.Biol., 384, 2008
5IVX
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BU of 5ivx by Molmil
Crystal Structure of B4.2.3 T-Cell Receptor and H2-Dd P18-I10 Complex
Descriptor: 1,2-ETHANEDIOL, Beta-2-microglobulin, H-2 class I histocompatibility antigen, ...
Authors:Natarajan, K, Jiang, J, Margulies, D.
Deposit date:2016-03-21
Release date:2017-03-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:An allosteric site in the T-cell receptor C beta domain plays a critical signalling role.
Nat Commun, 8, 2017
6P8D
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BU of 6p8d by Molmil
Vaccine-elicited murine FP-targeting antibody vFP6.01 in complex with HIV fusion peptide (residue 512-519)
Descriptor: Antibody VFP6.01 heavy chain, Antibody VFP6.01 light chain, HIV fusion peptide residue 512-519
Authors:Xu, K, Liu, K, Wang, Y, Kwong, P.D.
Deposit date:2019-06-07
Release date:2020-06-10
Method:X-RAY DIFFRACTION (2.102 Å)
Cite:Modular recognition of antigens provides a mechanism that improves vaccine-elicited antibody-class frequencies
To Be Published
5CMU
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BU of 5cmu by Molmil
Artificial HIV fusion inhibitor AP1 fused to the C-terminus of gp41 NHR
Descriptor: Envelope glycoprotein,AP1, GLYCEROL
Authors:Zhu, Y, Ye, S, Zhang, R.
Deposit date:2015-07-17
Release date:2015-09-16
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.113 Å)
Cite:Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy.
Sci Rep, 5, 2015
5TKJ
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BU of 5tkj by Molmil
Structure of vaccine-elicited diverse HIV-1 neutralizing antibody vFP1.01 in complex with HIV-1 fusion peptide residue 512-519
Descriptor: HIV-1 fusion peptide residue 512-519, SULFATE ION, vFP1.01 chimeric mouse antibody heavy chain, ...
Authors:Xu, K, Liu, K, Kwong, P.D.
Deposit date:2016-10-06
Release date:2018-04-04
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.118 Å)
Cite:Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1.
Nat. Med., 24, 2018

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