5NDW
 
 | | Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Prokhorova, I, Djumagulov, M, Urzhumtsev, A, Yusupov, M, Yusupova, G. | | Deposit date: | 2017-03-09 | | Release date: | 2017-12-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.7 Å) | | Cite: | Aminoglycoside interactions and impacts on the eukaryotic ribosome.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6WDR
 | | Subunit joining exposes nascent pre-40S rRNA for processing and quality control | | Descriptor: | 20S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S10-A, ... | | Authors: | Rai, J, Parker, M.D, Huang, H, Choy, S, Ghalei, H, Johnson, M.C, Karbstein, K, Stroupe, M.E. | | Deposit date: | 2020-04-01 | | Release date: | 2020-09-30 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | An open interface in the pre-80S ribosome coordinated by ribosome assembly factors Tsr1 and Dim1 enables temporal regulation of Fap7.
Rna, 27, 2021
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8CMJ
 | | Translocation intermediate 4 (TI-4*) of 80S S. cerevisiae ribosome with eEF2 in the absence of sordarin | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Milicevic, N, Jenner, L, Myasnikov, A, Yusupov, M, Yusupova, G. | | Deposit date: | 2023-02-20 | | Release date: | 2023-09-20 | | Last modified: | 2024-04-24 | | Method: | ELECTRON MICROSCOPY (3.79 Å) | | Cite: | mRNA reading frame maintenance during eukaryotic ribosome translocation.
Nature, 625, 2024
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5MC6
 | | Cryo-EM structure of a native ribosome-Ski2-Ski3-Ski8 complex from S. cerevisiae | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Schmidt, C, Kowalinski, E, Shanmuganathan, V, Defenouillere, Q, Braunger, K, Heuer, A, Pech, M, Namane, A, Berninghausen, O, Fromont-Racine, M, Jacquier, A, Conti, E, Becker, T, Beckmann, R. | | Deposit date: | 2016-11-09 | | Release date: | 2017-01-18 | | Last modified: | 2019-12-11 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | The cryo-EM structure of a ribosome-Ski2-Ski3-Ski8 helicase complex.
Science, 354, 2016
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8CBJ
 | | Cryo-EM structure of Otu2-bound cytoplasmic pre-40S ribosome biogenesis complex | | Descriptor: | 20S pre-ribosomal RNA, 20S-pre-rRNA D-site endonuclease NOB1, 40S ribosomal protein S0-A, ... | | Authors: | Ikeuchi, K, Buschauer, R, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | | Deposit date: | 2023-01-25 | | Release date: | 2023-05-24 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Molecular basis for recognition and deubiquitination of 40S ribosomes by Otu2.
Nat Commun, 14, 2023
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6RBE
 | | State 2 of yeast Tsr1-TAP Rps20-Deltaloop pre-40S particles | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | | Authors: | Shayan, R, Mitterer, V, Ferreira-Cerca, S, Murat, G, Enne, T, Rinaldi, D, Weigl, S, Omanic, H, Gleizes, P.E, Kressler, D, Pertschy, B, Plisson-Chastang, C. | | Deposit date: | 2019-04-10 | | Release date: | 2019-06-26 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Conformational proofreading of distant 40S ribosomal subunit maturation events by a long-range communication mechanism.
Nat Commun, 10, 2019
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8BQX
 | | Yeast 80S ribosome in complex with Map1 (conformation 2) | | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | | Authors: | Knorr, A.G, Mackens-Kiani, T, Musial, J, Berninghausen, O, Becker, T, Beatrix, B, Beckmann, R. | | Deposit date: | 2022-11-21 | | Release date: | 2023-03-22 | | Last modified: | 2023-05-03 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | The dynamic architecture of Map1- and NatB-ribosome complexes coordinates the sequential modifications of nascent polypeptide chains.
Plos Biol., 21, 2023
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6Y7C
 | | Early cytoplasmic yeast pre-40S particle (purified with Tsr1 as bait) | | Descriptor: | 20S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | | Authors: | Shayan, R, Plassart, L, Plisson-Chastang, C. | | Deposit date: | 2020-02-28 | | Release date: | 2020-03-18 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Good Vibrations: Structural Remodeling of Maturing Yeast Pre-40S Ribosomal Particles Followed by Cryo-Electron Microscopy.
Molecules, 25, 2020
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6GQB
 | | Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GDP+AlF4/sordarin) | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | | Authors: | Pellegrino, S, Yusupov, M, Yusupova, G, Hashem, Y. | | Deposit date: | 2018-06-07 | | Release date: | 2018-07-11 | | Last modified: | 2021-08-04 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
J. Mol. Biol., 430, 2018
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8BQD
 | | Yeast 80S ribosome in complex with Map1 (conformation 1) | | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | | Authors: | Knorr, A.G, Mackens-Kiani, T, Musial, J, Berninghausen, O, Becker, T, Beatrix, B, Beckmann, R. | | Deposit date: | 2022-11-21 | | Release date: | 2023-03-22 | | Last modified: | 2023-05-03 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | The dynamic architecture of Map1- and NatB-ribosome complexes coordinates the sequential modifications of nascent polypeptide chains.
Plos Biol., 21, 2023
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7NRC
 | | Structure of the yeast Gcn1 bound to a leading stalled 80S ribosome with Rbg2, Gir2, A- and P-tRNA and eIF5A | | Descriptor: | 18S rRNA (1771-MER), 25S rRNA (3184-MER), 40S ribosomal protein S0-A, ... | | Authors: | Pochopien, A.A, Beckert, B, Wilson, D.N. | | Deposit date: | 2021-03-03 | | Release date: | 2021-05-05 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structure of Gcn1 bound to stalled and colliding 80S ribosomes.
Proc.Natl.Acad.Sci.USA, 118, 2021
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4V7R
 | | Yeast 80S ribosome. | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Ben-Shem, A, Jenner, L, Yusupova, G, Yusupov, M. | | Deposit date: | 2010-07-23 | | Release date: | 2014-07-09 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (4 Å) | | Cite: | Crystal structure of the eukaryotic ribosome.
Science, 330, 2010
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5JUT
 | | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure IV (almost non-rotated 40S subunit) | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 5.8S ribosomal RNA, ... | | Authors: | Abeyrathne, P, Koh, C.S, Grant, T, Grigorieff, N, Korostelev, A.A. | | Deposit date: | 2016-05-10 | | Release date: | 2016-10-05 | | Last modified: | 2019-11-27 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome.
Elife, 5, 2016
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5JUO
 | | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure I (fully rotated 40S subunit) | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 5.8S ribosomal RNA, ... | | Authors: | Abeyrathne, P, Koh, C.S, Grant, T, Grigorieff, N, Korostelev, A.A. | | Deposit date: | 2016-05-10 | | Release date: | 2016-10-05 | | Last modified: | 2019-11-27 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome.
Elife, 5, 2016
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6GQV
 | | Cryo-EM recosntruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP) | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Pellegrino, S, Yusupov, M, Yusupova, G, Hashem, Y. | | Deposit date: | 2018-06-08 | | Release date: | 2018-07-11 | | Last modified: | 2018-08-08 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
J. Mol. Biol., 430, 2018
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6T83
 | | Structure of yeast disome (di-ribosome) stalled on poly(A) tract. | | Descriptor: | 18S rRNA, 25S rRNA, 40S ribosomal protein S0-A, ... | | Authors: | Tesina, P, Buschauer, R, Cheng, J, Berninghausen, O, Becker, R, Beckmann, R. | | Deposit date: | 2019-10-24 | | Release date: | 2019-12-25 | | Last modified: | 2020-02-12 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Molecular mechanism of translational stalling by inhibitory codon combinations and poly(A) tracts.
Embo J., 39, 2020
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5JUU
 | | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure V (least rotated 40S subunit) | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 5.8S ribosomal RNA, ... | | Authors: | Abeyrathne, P, Koh, C.S, Grant, T, Grigorieff, N, Korostelev, A.A. | | Deposit date: | 2016-05-10 | | Release date: | 2016-10-05 | | Last modified: | 2019-11-27 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome.
Elife, 5, 2016
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5JUS
 | | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure III (mid-rotated 40S subunit) | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 5.8S ribosomal RNA, ... | | Authors: | Abeyrathne, P, Koh, C.S, Grant, T, Grigorieff, N, Korostelev, A.A. | | Deposit date: | 2016-05-10 | | Release date: | 2016-10-05 | | Last modified: | 2023-04-05 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome.
Elife, 5, 2016
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4V8Y
 | | Cryo-EM reconstruction of the 80S-eIF5B-Met-itRNAMet Eukaryotic Translation Initiation Complex | | Descriptor: | 18S RIBOSOMAL RNA, 25S RIBOSOMAL RNA, 40S RIBOSOMAL PROTEIN S0-A, ... | | Authors: | Fernandez, I.S, Bai, X.C, Hussain, T, Kelley, A.C, Lorsch, J.R, Ramakrishnan, V, Scheres, S.H.W. | | Deposit date: | 2013-07-20 | | Release date: | 2014-07-09 | | Last modified: | 2024-06-26 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Molecular architecture of a eukaryotic translational initiation complex.
Science, 342, 2013
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7ZUW
 | | Structure of RQT (C1) bound to the stalled ribosome in a disome unit from S. cerevisiae | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Best, K.M, Ikeuchi, K, Kater, L, Best, D.M, Musial, J, Matsuo, Y, Berninghausen, O, Becker, T, Inada, T, Beckmann, R. | | Deposit date: | 2022-05-13 | | Release date: | 2023-02-22 | | Last modified: | 2023-03-01 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Structural basis for clearing of ribosome collisions by the RQT complex.
Nat Commun, 14, 2023
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7NRD
 | | Structure of the yeast Gcn1 bound to a colliding stalled 80S ribosome with MBF1, A/P-tRNA and P/E-tRNA | | Descriptor: | 25S rRNA (3184-MER), 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | | Authors: | Pochopien, A.A, Beckert, B, Wilson, D.N. | | Deposit date: | 2021-03-03 | | Release date: | 2021-04-14 | | Method: | ELECTRON MICROSCOPY (4.36 Å) | | Cite: | Structure of Gcn1 bound to stalled and colliding 80S ribosomes.
Proc.Natl.Acad.Sci.USA, 118, 2021
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6GQ1
 | | Cryo-EM reconstruction of yeast 80S ribosome in complex with mRNA, tRNA and eEF2 (GMPPCP/sordarin) | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | | Authors: | Pellegrino, S, Demeshkina, N, Mancera-Martinez, E, Melnikov, S, Simonetti, A, Myasnikov, A, Yusupov, M, Yusupova, G, Hashem, Y. | | Deposit date: | 2018-06-07 | | Release date: | 2018-07-11 | | Last modified: | 2018-08-08 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Structural Insights into the Role of Diphthamide on Elongation Factor 2 in mRNA Reading-Frame Maintenance.
J. Mol. Biol., 430, 2018
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7ZRS
 | | Structure of the RQT-bound 80S ribosome from S. cerevisiae (C2) - composite map | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Best, K.M, Ikeuchi, K, Kater, L, Best, D.M, Musial, J, Matsuo, Y, Berninghausen, O, Becker, T, Inada, T, Beckmann, R. | | Deposit date: | 2022-05-05 | | Release date: | 2023-02-22 | | Last modified: | 2023-03-01 | | Method: | ELECTRON MICROSCOPY (4.8 Å) | | Cite: | Structural basis for clearing of ribosome collisions by the RQT complex.
Nat Commun, 14, 2023
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6ZCE
 | | Structure of a yeast ABCE1-bound 43S pre-initiation complex | | Descriptor: | 18S ribosomal RNA (1719-MER), 40S ribosomal protein S0-A, 40S ribosomal protein S1-A, ... | | Authors: | Kratzat, H, Mackens-Kiani, T, Cheng, J, Berninghausen, O, Becker, T, Beckmann, R. | | Deposit date: | 2020-06-10 | | Release date: | 2020-10-07 | | Last modified: | 2021-01-13 | | Method: | ELECTRON MICROSCOPY (5.3 Å) | | Cite: | A structural inventory of native ribosomal ABCE1-43S pre-initiation complexes.
Embo J., 40, 2021
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6I7O
 | | The structure of a di-ribosome (disome) as a unit for RQC and NGD quality control pathways recognition. | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Tesina, P, Cheng, J, Becker, T, Beckmann, R. | | Deposit date: | 2018-11-16 | | Release date: | 2019-01-16 | | Last modified: | 2019-03-13 | | Method: | ELECTRON MICROSCOPY (5.3 Å) | | Cite: | Collided ribosomes form a unique structural interface to induce Hel2-driven quality control pathways.
EMBO J., 38, 2019
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