The structure of a di-ribosome (disome) as a unit for RQC and NGD quality control pathways recognition.

This is a large structure.

Summary for 6I7O

EMDB information4427
Descriptor25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ... (85 entities in total)
Functional Keywordsribosome, disome, di-ribosome, stalling, translation
Biological sourceSaccharomyces cerevisiae
Total number of polymer chains163
Total molecular weight6232473.68
Tesina, P.,Cheng, J.,Becker, T.,Beckmann, R. (deposition date: 2018-11-16, release date: 2019-01-16)
Primary citation
Ikeuchi, K.,Tesina, P.,Matsuo, Y.,Sugiyama, T.,Cheng, J.,Saeki, Y.,Tanaka, K.,Becker, T.,Beckmann, R.,Inada, T.
Collided ribosomes form a unique structural interface to induce Hel2-driven quality control pathways.
EMBO J., 2019
PubMed: 30609991 (PDB entries with the same primary citation)
DOI: 10.15252/embj.2018100276
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone7 0.8% 0.5% 0.48MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 6i7o
no rotation
Molmil generated image of 6i7o
rotated about x axis by 90°
Molmil generated image of 6i7o
rotated about y axis by 90°
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