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PDB: 69 results
5FI6
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BU of 5fi6 by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL_00011: 2-phenyl-~{N}-[5-[[(3~{S})-1-[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide
Descriptor: 2-phenyl-~{N}-[5-[[(3~{S})-1-[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]pyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.
Deposit date:2015-12-22
Release date:2016-05-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Design and evaluation of novel glutaminase inhibitors.
Bioorg.Med.Chem., 24, 2016
5HL1
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BU of 5hl1 by Molmil
Crystal structure of glutaminase C in complex with inhibitor CB-839
Descriptor: 2-(pyridin-2-yl)-N-(5-{4-[6-({[3-(trifluoromethoxy)phenyl]acetyl}amino)pyridazin-3-yl]butyl}-1,3,4-thiadiazol-2-yl)acetamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.A.
Deposit date:2016-01-14
Release date:2016-08-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the clinically relevant glutaminase inhibitot CB-839 in complex with glutaminase C
To Be Published
5FI7
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BU of 5fi7 by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL_00015: 2-phenyl-~{N}-[5-[(3~{S})-3-[[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]oxy]pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl]ethanamide
Descriptor: 2-phenyl-~{N}-[5-[(3~{S})-3-[[5-(2-phenylethanoylamino)-1,3,4-thiadiazol-2-yl]oxy]pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.
Deposit date:2015-12-22
Release date:2016-05-11
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design and evaluation of novel glutaminase inhibitors.
Bioorg.Med.Chem., 24, 2016
3SS3
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BU of 3ss3 by Molmil
Crystal structure of mouse Glutaminase C, ligand-free form
Descriptor: CHLORIDE ION, Glutaminase C
Authors:Ambrosio, A.L.B, Dias, S.M.G, Cerione, R.A.
Deposit date:2011-07-07
Release date:2012-01-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism.
Proc.Natl.Acad.Sci.USA, 109, 2012
3SS5
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BU of 3ss5 by Molmil
Crystal structure of mouse Glutaminase C, L-glutamate-bound form
Descriptor: GLUTAMIC ACID, Glutaminase C
Authors:Ambrosio, A.L.B, Dias, S.M.G, Cerione, R.A.
Deposit date:2011-07-07
Release date:2012-01-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism.
Proc.Natl.Acad.Sci.USA, 109, 2012
3SS4
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BU of 3ss4 by Molmil
Crystal structure of mouse Glutaminase C, phosphate-bound form
Descriptor: Glutaminase C, PHOSPHATE ION
Authors:Ambrosio, A.L.B, Dias, S.M.G, Cerione, R.A.
Deposit date:2011-07-07
Release date:2012-01-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Mitochondrial localization and structure-based phosphate activation mechanism of Glutaminase C with implications for cancer metabolism.
Proc.Natl.Acad.Sci.USA, 109, 2012
3UNW
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BU of 3unw by Molmil
Crystal Structure of Human GAC in Complex with Glutamate
Descriptor: GLUTAMIC ACID, Glutaminase kidney isoform, mitochondrial
Authors:DeLaBarre, B, Gross, S, Cheng, F, Gao, Y, Jha, A, Jiang, F, Song, J.J, Wie, W, Hurov, J.
Deposit date:2011-11-16
Release date:2011-12-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Full-length human glutaminase in complex with an allosteric inhibitor.
Biochemistry, 50, 2011
3UO9
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BU of 3uo9 by Molmil
Crystal Structure of Human GAC in Complex with Glutamate and BPTES
Descriptor: GLYCEROL, Glutaminase kidney isoform, mitochondrial, ...
Authors:DeLaBarre, B, Gross, S, Cheng, F, Gao, Y, Jha, A, Jiang, F, Song, J.J, Wei, W, Hurov, J.B.
Deposit date:2011-11-16
Release date:2011-12-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Full-length human glutaminase in complex with an allosteric inhibitor.
Biochemistry, 50, 2011
6UJG
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BU of 6ujg by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
Descriptor: Glutaminase kidney isoform, mitochondrial, N-{5-[(3S)-3-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]amino}pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-03
Release date:2020-10-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
6UME
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BU of 6ume by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
Descriptor: 2-(pyridin-3-yl)-N-(5-{4-[(5-{[(pyridin-3-yl)acetyl]amino}-1,3,4-thiadiazol-2-yl)amino]piperidin-1-yl}-1,3,4-thiadiazol-2-yl)acetamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-09
Release date:2020-10-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
6UMD
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BU of 6umd by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
Descriptor: 2-(pyridin-3-yl)-N-(5-{4-[(5-{[(pyridin-3-yl)acetyl]amino}-1,3,4-thiadiazol-2-yl)amino]piperidin-1-yl}-1,3,4-thiadiazol-2-yl)acetamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-09
Release date:2020-10-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
6UMC
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BU of 6umc by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
Descriptor: 2-phenyl-N-{5-[(3R)-3-({5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-09
Release date:2020-10-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
6ULJ
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BU of 6ulj by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
Descriptor: 2-phenyl-N-{6-[4-({6-[(phenylacetyl)amino]pyridazin-3-yl}oxy)piperidin-1-yl]pyridazin-3-yl}acetamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-08
Release date:2020-10-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00045
To Be Published
6UMF
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BU of 6umf by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
Descriptor: Glutaminase kidney isoform, mitochondrial, N-(5-{[1-(5-amino-1,3,4-thiadiazol-2-yl)piperidin-4-yl]oxy}-1,3,4-thiadiazol-2-yl)-2-phenylacetamide
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-09
Release date:2020-10-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
6UK6
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BU of 6uk6 by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00018
Descriptor: 5-{4-[(5-amino-1,3,4-thiadiazol-2-yl)oxy]piperidin-1-yl}-1,3,4-thiadiazol-2-amine, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-04
Release date:2020-10-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00018
To Be Published
6UKB
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BU of 6ukb by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
Descriptor: Glutaminase kidney isoform, mitochondrial, N-[5-(4-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]oxy}piperidin-1-yl)-1,3,4-thiadiazol-2-yl]acetamide
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-04
Release date:2020-10-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00020
To Be Published
6ULA
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BU of 6ula by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00012
Descriptor: 2-cyclopropyl-N-{5-[4-({5-[(cyclopropylacetyl)amino]-1,3,4-thiadiazol-2-yl}oxy)piperidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-07
Release date:2020-10-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00030
To Be Published
6UJM
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BU of 6ujm by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00013
Descriptor: Glutaminase kidney isoform, mitochondrial, N-{5-[(3R)-3-{[5-(acetylamino)-1,3,4-thiadiazol-2-yl]amino}pyrrolidin-1-yl]-1,3,4-thiadiazol-2-yl}acetamide
Authors:Huang, Q, Cerione, R.A.
Deposit date:2019-10-03
Release date:2020-10-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00013
To Be Published
6UL9
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BU of 6ul9 by Molmil
Crystal structure of human GAC in complex with inhibitor UPGL00023
Descriptor: 2-phenyl-N-{5-[(1-{5-[(phenylacetyl)amino]-1,3,4-thiadiazol-2-yl}azetidin-3-yl)oxy]-1,3,4-thiadiazol-2-yl}acetamide, Glutaminase kidney isoform, mitochondrial
Authors:Huang, Q.Q, Cerione, R.A.
Deposit date:2019-10-07
Release date:2020-10-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human GAC in complex with inhibitor UPGL00012
To Be Published
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