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PDB: 673 results

1ZD5
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BU of 1zd5 by Molmil
Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-heptanoic acid complex
Descriptor: 7-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEPTANOIC ACID, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
Deposit date:2005-04-14
Release date:2006-03-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids
Protein Sci., 15, 2006
4QF0
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BU of 4qf0 by Molmil
Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, quadruple mutant, P21212 form
Descriptor: Non-haem bromoperoxidase BPO-A2, Matrix protein 1 chimera
Authors:Lai, Y.-T, Yeates, T.O.
Deposit date:2014-05-19
Release date:2015-05-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (6.494 Å)
Cite:Structural transition of a protein nanocage as a function of pH and salt concentration.
To be Published
4QES
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BU of 4qes by Molmil
Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, quadruple mutant, I222 form
Descriptor: Non-haem bromoperoxidase BPO-A2, Matrix protein 1 chimera
Authors:Lai, Y.-T, Yeates, T.O.
Deposit date:2014-05-18
Release date:2015-05-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (4.193 Å)
Cite:Structural transition of a protein nanocage as a function of pH and salt concentration.
To be Published
4QFF
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BU of 4qff by Molmil
Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, quadruple mutant, P212121 form
Descriptor: Non-haem bromoperoxidase BPO-A2, Matrix protein 1 chimera
Authors:Lai, Y.-T, Yeates, T.O.
Deposit date:2014-05-20
Release date:2015-05-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (7.811 Å)
Cite:Structural transition of a protein nanocage as a function of pH and salt concentration
To be Published
1ZD4
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BU of 1zd4 by Molmil
Human soluble epoxide hydrolase 4-(3-cyclohexyluriedo)-hexanoic acid complex
Descriptor: 6-{[(CYCLOHEXYLAMINO)CARBONYL]AMINO}HEXANOIC ACID, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
Deposit date:2005-04-14
Release date:2006-03-07
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Human soluble epoxide hydrolase: structural basis of inhibition by 4-(3-cyclohexylureido)-carboxylic acids
Protein Sci., 15, 2006
3I1Y
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BU of 3i1y by Molmil
Crystal Structure of soluble epoxide Hydrolase
Descriptor: Epoxide hydrolase 2, N-(3,3-diphenylpropyl)pyridine-3-carboxamide
Authors:Farrow, N.A.
Deposit date:2009-06-28
Release date:2009-10-13
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.469 Å)
Cite:Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase.
J.Med.Chem., 52, 2009
3I28
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BU of 3i28 by Molmil
Crystal Structure of soluble epoxide Hydrolase
Descriptor: 4-cyano-N-{(3S)-3-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]propyl}benzamide, Epoxide hydrolase 2
Authors:Farrow, N.A.
Deposit date:2009-06-29
Release date:2009-10-13
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase.
J.Med.Chem., 52, 2009
4IQ4
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BU of 4iq4 by Molmil
Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, triple mutant, P21212 form
Descriptor: Non-haem bromoperoxidase BPO-A2, Matrix protein 1
Authors:Lai, Y.-T, Sawaya, M.R, Yeates, T.O.
Deposit date:2013-01-10
Release date:2013-07-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.495 Å)
Cite:Structure and flexibility of nanoscale protein cages designed by symmetric self-assembly.
J.Am.Chem.Soc., 135, 2013
4ITV
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BU of 4itv by Molmil
Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, triple mutant, P212121 form
Descriptor: Non-haem bromoperoxidase BPO-A2, Matrix protein 1
Authors:Lai, Y.-T, Sawaya, M.R, Yeates, T.O.
Deposit date:2013-01-18
Release date:2013-07-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.598 Å)
Cite:Structure and flexibility of nanoscale protein cages designed by symmetric self-assembly.
J.Am.Chem.Soc., 135, 2013
1EK1
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BU of 1ek1 by Molmil
CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CIU INHIBITOR
Descriptor: EPOXIDE HYDROLASE, N-CYCLOHEXYL-N'-(4-IODOPHENYL)UREA
Authors:Argiriadi, M.A, Morisseau, C, Goodrow, M.H, Dowdy, D.L, Hammock, B.D, Christianson, D.W.
Deposit date:2000-03-06
Release date:2000-05-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation.
J.Biol.Chem., 275, 2000
1EK2
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BU of 1ek2 by Molmil
CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE COMPLEXED WITH CDU INHIBITOR
Descriptor: EPOXIDE HYDROLASE, N-CYCLOHEXYL-N'-DECYLUREA
Authors:Argiriadi, M.A, Morisseau, C, Goodrow, M.H, Dowdy, D.L, Hammock, B.D, Christianson, D.W.
Deposit date:2000-03-06
Release date:2000-05-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Binding of alkylurea inhibitors to epoxide hydrolase implicates active site tyrosines in substrate activation.
J.Biol.Chem., 275, 2000
4J03
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BU of 4j03 by Molmil
Crystal structure of human soluble epoxide hydrolase complexed with fulvestrant
Descriptor: (7beta,9beta,13alpha,17beta)-7-{9-[(R)-(4,4,5,5,5-pentafluoropentyl)sulfinyl]nonyl}estra-1(10),2,4-triene-3,17-diol, Bifunctional epoxide hydrolase 2, MAGNESIUM ION, ...
Authors:Morisseau, C, Pakhomova, S, Hwang, S.H, Newcomer, M.E, Hammock, B.D.
Deposit date:2013-01-30
Release date:2013-06-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Inhibition of soluble epoxide hydrolase by fulvestrant and sulfoxides.
Bioorg.Med.Chem.Lett., 23, 2013
4D9J
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BU of 4d9j by Molmil
Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains
Descriptor: Designed 16nm tetrahedral protein cage containing Non-haem bromoperoxidase BPO-A2 and Matrix protein 1
Authors:Lai, Y.-T, Cascio, D, Yeates, T.O.
Deposit date:2012-01-11
Release date:2012-06-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (3.92 Å)
Cite:Structure of a 16-nm cage designed by using protein oligomers.
Science, 336, 2012
4IVJ
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BU of 4ivj by Molmil
Structure of a 16 nm protein cage designed by fusing symmetric oligomeric domains, triple mutant, I222 form
Descriptor: Non-haem bromoperoxidase BPO-A2, Matrix protein 1
Authors:Lai, Y.-T, Sawaya, M.R, Yeates, T.O.
Deposit date:2013-01-23
Release date:2013-07-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (7.351 Å)
Cite:Structure and flexibility of nanoscale protein cages designed by symmetric self-assembly.
J.Am.Chem.Soc., 135, 2013
6AUM
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BU of 6aum by Molmil
Crystal structure of human soluble epoxide hydrolase complexed with trans-4-[4-(3-trifluoromethoxyphenyl-l-ureido)-cyclohexyloxy]-benzoic acid.
Descriptor: 4-{[trans-4-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)cyclohexyl]oxy}benzoic acid, Bifunctional epoxide hydrolase 2, CHLORIDE ION, ...
Authors:Kodani, S.D, Bahkta, S, Hwang, S.H, Pakhomova, S, Newcomer, M.E, Morisseau, C, Hammock, B.
Deposit date:2017-09-01
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Identification and optimization of soluble epoxide hydrolase inhibitors with dual potency towards fatty acid amide hydrolase.
Bioorg. Med. Chem. Lett., 28, 2018
6II2
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BU of 6ii2 by Molmil
Crystal structure of alpha-beta hydrolase (ABH) and Makes Caterpillars Floppy (MCF)-Like effectors of Vibrio vulnificus MO6-24/O
Descriptor: Putative RTX-toxin
Authors:Lee, Y, Kim, B.S, Choi, S, Lee, E.Y, Park, S, Hwang, J, Kwon, Y, Hyung, J, Lee, C, Eom, S.H, Kim, M.H.
Deposit date:2018-10-03
Release date:2019-08-07
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Makes caterpillars floppy-like effector-containing MARTX toxins require host ADP-ribosylation factor (ARF) proteins for systemic pathogenicity.
Proc.Natl.Acad.Sci.USA, 116, 2019
3OTQ
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BU of 3otq by Molmil
Soluble Epoxide Hydrolase in complex with pyrazole antagonist
Descriptor: Epoxide hydrolase 2, N-[4-(5-ethyl-3-pyridin-3-yl-1H-pyrazol-1-yl)phenyl]pyridine-3-carboxamide
Authors:Farrow, N.A.
Deposit date:2010-09-13
Release date:2010-10-27
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Substituted pyrazoles as novel sEH antagonist: investigation of key binding interactions within the catalytic domain.
Bioorg.Med.Chem.Lett., 20, 2010
1CQZ
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BU of 1cqz by Molmil
CRYSTAL STRUCTURE OF MURINE SOLUBLE EPOXIDE HYDROLASE.
Descriptor: EPOXIDE HYDROLASE
Authors:Argiriadi, M.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
Deposit date:1999-08-12
Release date:1999-11-19
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Detoxification of environmental mutagens and carcinogens: structure, mechanism, and evolution of liver epoxide hydrolase.
Proc.Natl.Acad.Sci.USA, 96, 1999
1VJ5
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BU of 1vj5 by Molmil
Human soluble Epoxide Hydrolase- N-cyclohexyl-N'-(4-iodophenyl)urea complex
Descriptor: HEXAETHYLENE GLYCOL, MAGNESIUM ION, N-CYCLOHEXYL-N'-(4-IODOPHENYL)UREA, ...
Authors:Gomez, G.A, Morisseau, C, Hammock, B.D, Christianson, D.W.
Deposit date:2004-02-03
Release date:2004-04-27
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure of human epoxide hydrolase reveals mechanistic inferences on bifunctional catalysis in epoxide and phosphate ester hydrolysis
Biochemistry, 43, 2004
4HAI
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BU of 4hai by Molmil
Crystal structure of human soluble epoxide hydrolase complexed with N-cycloheptyl-1-(mesitylsulfonyl)piperidine-4-carboxamide.
Descriptor: Bifunctional epoxide hydrolase 2, MAGNESIUM ION, N-cycloheptyl-1-[(2,4,6-trimethylphenyl)sulfonyl]piperidine-4-carboxamide, ...
Authors:Pecic, S, Pakhomova, S, Newcomer, M.E, Morisseau, C, Hammock, B.D, Zhu, Z, Deng, S.
Deposit date:2012-09-26
Release date:2012-12-26
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
5ALM
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BU of 5alm by Molmil
ligand complex structure of soluble epoxide hydrolase
Descriptor: (3R)-1-(cyclopropylmethyl)-3-methyl-3-(4-methylsulfanylphenoxy)pyrrolidine, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE
Authors:Oster, L, Tapani, S, Xue, Y, Kack, H.
Deposit date:2015-03-08
Release date:2015-05-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Successful Generation of Structural Information for Fragment-Based Drug Discovery.
Drug Discov Today, 20, 2015
5ALO
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BU of 5alo by Molmil
ligand complex structure of soluble epoxide hydrolase
Descriptor: 3-BENZYL-3-METHYL-5-(1-METHYLPYRAZOL-4-YL)INDOLIN-2-ONE, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE
Authors:Oster, L, Tapani, S, Xue, Y, Kack, H.
Deposit date:2015-03-08
Release date:2015-05-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2 Å)
Cite:Successful Generation of Structural Information for Fragment-Based Drug Discovery.
Drug Discov Today, 20, 2015
5AM5
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BU of 5am5 by Molmil
ligand complex structure of soluble epoxide hydrolase
Descriptor: 5-cyclohexyl-3-propyl-1H-pyridin-2-one, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE
Authors:Oster, L, Tapani, S, Xue, Y, Kack, H.
Deposit date:2015-03-09
Release date:2015-05-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Successful Generation of Structural Information for Fragment-Based Drug Discovery.
Drug Discov Today, 20, 2015
5ALT
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BU of 5alt by Molmil
ligand complex structure of soluble epoxide hydrolase
Descriptor: 3-(2-methyltetrazol-5-yl)-5-(3-thienyl)pyridin-2-amine, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DI(HYDROXYETHYL)ETHER, ...
Authors:Oster, L, Tapani, S, Xue, Y, Kack, H.
Deposit date:2015-03-08
Release date:2015-05-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Successful Generation of Structural Information for Fragment-Based Drug Discovery.
Drug Discov Today, 20, 2015
5AM4
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BU of 5am4 by Molmil
ligand complex structure of soluble epoxide hydrolase
Descriptor: 5-cyclohexylspiro[1H-indole-3,4'-oxane]-2-one, BIFUNCTIONAL EPOXIDE HYDROLASE 2, DIMETHYL SULFOXIDE, ...
Authors:Oster, L, Tapani, S, Xue, Y, Kack, H.
Deposit date:2015-03-09
Release date:2015-05-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Successful Generation of Structural Information for Fragment-Based Drug Discovery.
Drug Discov Today, 20, 2015

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