8FUC
 
 | | Crystal structure of mouse Importin alpha in complex with Hendra virus matrix protein minor site NLS2 | | Descriptor: | Contaminant peptide KKLARE, Importin subunit alpha-1, Matrix protein | | Authors: | Donnelly, C.M, Basler, C.F, Scott, C, Forwood, J.K. | | Deposit date: | 2023-01-17 | | Release date: | 2023-01-25 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Henipavirus Matrix Protein Employs a Non-Classical Nuclear Localization Signal Binding Mechanism.
Viruses, 15, 2023
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4BA3
 | | mImp_alphadIBB_A89NLS | | Descriptor: | A89NLS, IMPORTIN SUBUNIT ALPHA-2 | | Authors: | Chang, C.-W, Counago, R.L.M, Williams, S.J, Boden, M, Kobe, B. | | Deposit date: | 2012-09-11 | | Release date: | 2013-01-09 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure of Rice Importin-Alpha and Structural Basis of its Interaction with Plant-Specific Nuclear Localization Signals.
Plant Cell, 24, 2012
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3ZIO
 | | minor-site specific NLS (A28) | | Descriptor: | A28NLS, IMPORTIN SUBUNIT ALPHA-2 | | Authors: | Chang, C.-W, Counago, R.M, Williams, S.J, Kobe, B. | | Deposit date: | 2013-01-10 | | Release date: | 2013-08-21 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Distinctive Conformation of Minor Site-Specific Nuclear Localization Signals Bound to Importin-Alpha
Traffic, 14, 2013
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4OIH
 | | Importin Alpha in Complex with the Bipartite NLS of Prp20 | | Descriptor: | Guanine nucleotide exchange factor SRM1, Importin subunit alpha-1 | | Authors: | Roman, N, Christie, M, Swarbrick, C.M.D, Kobe, B, Forwood, J.K. | | Deposit date: | 2014-01-19 | | Release date: | 2014-02-19 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural Characterisation of the Nuclear Import Receptor Importin Alpha in Complex with the Bipartite NLS of Prp20
Plos One, 8, 2013
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3UKW
 | | Mouse importin alpha: Bimax1 peptide complex | | Descriptor: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Bimax1 peptide, Importin subunit alpha-2 | | Authors: | Marfori, M, Forwood, J.K, Lonhienne, T.G, Kobe, B. | | Deposit date: | 2011-11-10 | | Release date: | 2012-10-03 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural Basis of High-Affinity Nuclear Localization Signal Interactions with Importin-alpha
Traffic, 13, 2012
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4U5S
 | | IMPORTIN-ALPHA MINOR NLS SITE INHIBITOR | | Descriptor: | Importin subunit alpha-1, N-[(2S)-2-[(N~2~-acetyl-D-lysyl)amino]-3-(pyridin-3-ylmethoxy)propyl]-L-allothreonyl-D-phenylalaninamide | | Authors: | Stewart, M, Valkov, E, Holvey, R.S. | | Deposit date: | 2014-07-25 | | Release date: | 2015-05-13 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.12 Å) | | Cite: | Selective Targeting of the TPX2 Site of Importin-alpha Using Fragment-Based Ligand Design.
Chemmedchem, 10, 2015
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8TUR
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5X8N
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6WBC
 | | Structure of Mouse Importin alpha- MLH1-R472K NLS Peptide Complex | | Descriptor: | DNA mismatch repair protein Mlh1, Importin subunit alpha-1 | | Authors: | de Barros, A.C, da Silva, T.D, Oliveira, H.C, Fukuda, C.A, Fontes, M.R.M. | | Deposit date: | 2020-03-26 | | Release date: | 2021-07-07 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha.
Biochem.J., 478, 2021
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5V5P
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6P6A
 | | Structure of Mouse Importin alpha - NIT2 NLS peptide complex | | Descriptor: | Importin subunit alpha-1, Nitrogen catabolic enzyme regulatory protein | | Authors: | Bernardes, N.E, Fukuda, C.A, Silva, T.D, Oliveira, H.C, Fontes, M.R.M. | | Deposit date: | 2019-06-03 | | Release date: | 2020-01-29 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.151 Å) | | Cite: | Comparative study of the interactions between fungal transcription factor nuclear localization sequences with mammalian and fungal importin-alpha.
Sci Rep, 10, 2020
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6WBA
 | | Structure of Mouse Importin alpha MLH1- R470A NLS Peptide Complex | | Descriptor: | DNA mismatch repair protein Mlh1, Importin subunit alpha-1 | | Authors: | de Barros, A.C, da Silva, T.D, Oliveira, H.C, Fukuda, C.A, Fontes, M.R.M. | | Deposit date: | 2020-03-26 | | Release date: | 2021-07-07 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.151 Å) | | Cite: | Structural and calorimetric studies reveal specific determinants for the binding of a high-affinity NLS to mammalian importin-alpha.
Biochem.J., 478, 2021
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3KND
 | | TPX2:importin-alpha complex | | Descriptor: | Importin subunit alpha-2, SULFATE ION, Targeting protein for Xklp2 | | Authors: | Stewart, M. | | Deposit date: | 2009-11-12 | | Release date: | 2010-03-23 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.151 Å) | | Cite: | Novel binding of the mitotic regulator TPX2 (target protein for Xenopus kinesin-like protein 2) to importin-alpha.
J.Biol.Chem., 285, 2010
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5U5P
 | | Crystal Structure and X-ray Diffraction Data Collection of Importin-alpha from Mus Musculus Complexed with a MLH1 NLS Peptide | | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, DNA mismatch repair protein Mlh1, Importin subunit alpha-1 | | Authors: | Barros, A.C, Takeda, A.A, Dreyer, T.R, Velazquez-Campoy, A, Kobe, B, Fontes, M.R. | | Deposit date: | 2016-12-07 | | Release date: | 2018-03-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.171 Å) | | Cite: | DNA mismatch repair proteins MLH1 and PMS2 can be imported to the nucleus by a classical nuclear import pathway.
Biochimie, 146, 2018
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5W4E
 | | Importin binding to Tdt NLS peptide | | Descriptor: | GLYCEROL, Importin subunit alpha-1,Importin subunit alpha-1, human DNA repair polymerase Tdt | | Authors: | Pedersen, L.C, London, R. | | Deposit date: | 2017-06-10 | | Release date: | 2018-06-27 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Variations in nuclear localization strategies among pol X family enzymes.
Traffic, 2018
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6D7M
 | | Crystal structure of the W184R/W231R Importin alpha mutant | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Peroxidase,Importin subunit alpha-1, ... | | Authors: | Pedersen, L.C, London, R.E, Gabel, S.A. | | Deposit date: | 2018-04-25 | | Release date: | 2019-03-06 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.187 Å) | | Cite: | Variations in nuclear localization strategies among pol X family enzymes.
Traffic, 2018
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5W41
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8SV0
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2C1M
 | | Nup50:importin-alpha complex | | Descriptor: | IMPORTIN-ALPHA2 SUBUNIT, NUCLEOPORIN 50 KDA | | Authors: | Matsuura, Y, Stewart, M. | | Deposit date: | 2005-09-16 | | Release date: | 2005-11-23 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Nup50/Npap60 Function in Nuclear Protein Import Complex Disassembly and Importin Recycling.
Embo J., 24, 2005
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5WUN
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7JVO
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6BW1
 | | Hendra virus W protein C-terminus in complex with Importin alpha 1 | | Descriptor: | Importin subunit alpha-1, Protein W | | Authors: | Tsimbalyuk, S, Smith, K.M, Edwards, M.R, Aragao, D, Cross, E.M, Basler, C.F, Forwood, J.K. | | Deposit date: | 2017-12-14 | | Release date: | 2018-07-04 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis for importin alpha 3 specificity of W proteins in Hendra and Nipah viruses.
Nat Commun, 9, 2018
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5KLR
 | | Prototypical P4[R]cNLS | | Descriptor: | Importin subunit alpha-1, Prototypical P4[R]cNLS | | Authors: | Smith, K.M, Forwood, J.K. | | Deposit date: | 2016-06-25 | | Release date: | 2016-07-27 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Contribution of the residue at position 4 within classical nuclear localization signals to modulating interaction with importins and nuclear targeting.
Biochim Biophys Acta Mol Cell Res, 1865, 2018
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5HHG
 | | Mouse importin alpha: Dengue 2 NS5 C-terminal NLS peptide complex | | Descriptor: | Importin subunit alpha-1, RNA-directed RNA polymerase NS5 | | Authors: | Smith, K.M, Forwood, J.K. | | Deposit date: | 2016-01-11 | | Release date: | 2016-05-18 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The C-terminal 18 Amino Acid Region of Dengue Virus NS5 Regulates its Subcellular Localization and Contains a Conserved Arginine Residue Essential for Infectious Virus Production.
PLoS Pathog., 12, 2016
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1Y2A
 | | Structure of mammalian importin bound to the non-classical PLSCR1-NLS | | Descriptor: | Importin alpha-2 Subunit, decamer fragment of Phospholipid scramblase 1 | | Authors: | Chen, M.-H, Ben-Efraim, I, Mitrousis, G, Walker-Kopp, N, Sims, P.J, Cingolani, G. | | Deposit date: | 2004-11-22 | | Release date: | 2005-02-01 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Phospholipid Scramblase 1 Contains a Nonclassical Nuclear Localization Signal with Unique Binding Site in Importin alpha
J.Biol.Chem., 280, 2005
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