2FK2
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2FMA
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5MYO
| Structure of Pyroglutamate-Abeta-specific Fab c#6 in complex with human Abeta-pE3-12-PEGb | Descriptor: | Amyloid beta A4 protein, Fab c#6 heavy chain, Fab c#6 light chain, ... | Authors: | Parthier, C, Piechotta, A, Stubbs, M.T. | Deposit date: | 2017-01-27 | Release date: | 2017-06-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.59 Å) | Cite: | Structural and functional analyses of pyroglutamate-amyloid-beta-specific antibodies as a basis for Alzheimer immunotherapy. J. Biol. Chem., 292, 2017
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5NX1
| Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy | Descriptor: | Amyloid-beta A4 protein, Kallikrein-6 | Authors: | Shahar, A, Sananes, A, Radisky, E.S, Papo, N. | Deposit date: | 2017-05-09 | Release date: | 2018-05-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.853 Å) | Cite: | A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering. J.Biol.Chem., 293, 2018
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5NX3
| Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy | Descriptor: | Amyloid-beta A4 protein, Kallikrein-6 | Authors: | Shahar, A, Sananes, A, Radisky, E.S, Papo, N. | Deposit date: | 2017-05-09 | Release date: | 2018-05-30 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.296 Å) | Cite: | A potent, proteolysis-resistant inhibitor of kallikrein-related peptidase 6 (KLK6) for cancer therapy, developed by combinatorial engineering. J.Biol.Chem., 293, 2018
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1AMB
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1AMC
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1AML
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1CA0
| BOVINE CHYMOTRYPSIN COMPLEXED TO APPI | Descriptor: | BOVINE CHYMOTRYPSIN, PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR | Authors: | Scheidig, A.J, Kossiakoff, A.A. | Deposit date: | 1997-01-23 | Release date: | 1997-07-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of bovine chymotrypsin and trypsin complexed to the inhibitor domain of Alzheimer's amyloid beta-protein precursor (APPI) and basic pancreatic trypsin inhibitor (BPTI): engineering of inhibitors with altered specificities. Protein Sci., 6, 1997
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1BJC
| SOLUTION NMR STRUCTURE OF AMYLOID BETA[F16], RESIDUES 1-28, 15 STRUCTURES | Descriptor: | AMYLOID BETA-PEPTIDE | Authors: | Poulsen, S.-A, Watson, A.A, Craik, D.J. | Deposit date: | 1998-06-23 | Release date: | 1998-11-18 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structures in aqueous SDS micelles of two amyloid beta peptides of A beta(1-28) mutated at the alpha-secretase cleavage site (K16E, K16F) J.Struct.Biol., 130, 2000
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1BA4
| THE SOLUTION STRUCTURE OF AMYLOID BETA-PEPTIDE (1-40) IN A WATER-MICELLE ENVIRONMENT. IS THE MEMBRANE-SPANNING DOMAIN WHERE WE THINK IT IS? NMR, 10 STRUCTURES | Descriptor: | AMYLOID BETA-PEPTIDE | Authors: | Coles, M, Bicknell, W, Watson, A.A, Fairlie, D.P, Craik, D.J. | Deposit date: | 1998-04-07 | Release date: | 1998-06-17 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of amyloid beta-peptide(1-40) in a water-micelle environment. Is the membrane-spanning domain where we think it is? Biochemistry, 37, 1998
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2Y3L
| Structure of segment MVGGVVIA from the amyloid-beta peptide (Ab, residues 35-42), alternate polymorph 2 | Descriptor: | AMYLOID BETA A4 PROTEIN | Authors: | Colletier, J.P, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2010-12-21 | Release date: | 2011-11-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism. Proc.Natl.Acad.Sci.USA, 108, 2011
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2Y29
| Structure of segment KLVFFA from the amyloid-beta peptide (Ab, residues 16-21), alternate polymorph III | Descriptor: | AMYLOID BETA A4 PROTEIN | Authors: | Colletier, J, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2010-12-14 | Release date: | 2011-10-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism. Proc.Natl.Acad.Sci.USA, 108, 2011
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2Y2A
| Structure of segment KLVFFA from the amyloid-beta peptide (Ab, residues 16-21), alternate polymorph I | Descriptor: | ACETATE ION, AMYLOID BETA A4 PROTEIN | Authors: | Colletier, J, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2010-12-14 | Release date: | 2011-10-26 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism. Proc.Natl.Acad.Sci.USA, 108, 2011
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2Y3K
| Structure of segment MVGGVVIA from the amyloid-beta peptide (Ab, residues 35-42), alternate polymorph 1 | Descriptor: | AMYLOID BETA A4 PROTEIN | Authors: | Colletier, J.P, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2010-12-21 | Release date: | 2011-11-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism. Proc.Natl.Acad.Sci.USA, 108, 2011
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1BRC
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2Y3J
| Structure of segment AIIGLM from the amyloid-beta peptide (Ab, residues 30-35) | Descriptor: | AMYLOID BETA A4 PROTEIN | Authors: | Colletier, J.P, Laganowsky, A, Sawaya, M.R, Eisenberg, D. | Deposit date: | 2010-12-21 | Release date: | 2011-11-02 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Molecular Basis for Amyloid-{Beta} Polymorphism. Proc.Natl.Acad.Sci.USA, 108, 2011
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1BA6
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3AYU
| Crystal structure of MMP-2 active site mutant in complex with APP-drived decapeptide inhibitor | Descriptor: | 72 kDa type IV collagenase, Amyloid beta A4 protein, CALCIUM ION, ... | Authors: | Hashimoto, H, Takeuchi, T, Komatsu, K, Miyazaki, K, Sato, M, Higashi, S. | Deposit date: | 2011-05-17 | Release date: | 2011-08-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for matrix metalloproteinase-2 (MMP-2)-selective inhibitory action of {beta}-amyloid precursor protein-derived inhibitor J.Biol.Chem., 2011
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1AAP
| X-RAY CRYSTAL STRUCTURE OF THE PROTEASE INHIBITOR DOMAIN OF ALZHEIMER'S AMYLOID BETA-PROTEIN PRECURSOR | Descriptor: | ALZHEIMER'S DISEASE AMYLOID A4 PROTEIN | Authors: | Hynes, T.R, Randal, M, Kennedy, L.A, Eigenbrot, C, Kossiakoff, A.A. | Deposit date: | 1990-09-14 | Release date: | 1991-10-15 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | X-ray crystal structure of the protease inhibitor domain of Alzheimer's amyloid beta-protein precursor. Biochemistry, 29, 1990
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1BJB
| SOLUTION NMR STRUCTURE OF AMYLOID BETA[E16], RESIDUES 1-28, 14 STRUCTURES | Descriptor: | AMYLOID BETA-PEPTIDE | Authors: | Poulsen, S.-A, Watson, A.A, Craik, D.J. | Deposit date: | 1998-06-23 | Release date: | 1998-11-04 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structures in aqueous SDS micelles of two amyloid beta peptides of A beta(1-28) mutated at the alpha-secretase cleavage site (K16E, K16F) J.Struct.Biol., 130, 2000
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2LMN
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2LNQ
| 40-residue D23N beta amyloid fibril | Descriptor: | P3(40) | Authors: | Qiang, W, Yau, W, Luo, Y, Mattson, M.P, Tycko, R. | Deposit date: | 2012-01-03 | Release date: | 2012-02-08 | Last modified: | 2024-05-15 | Method: | SOLID-STATE NMR | Cite: | Antiparallel beta-sheet architecture in Iowa-mutant beta-amyloid fibrils. Proc.Natl.Acad.Sci.USA, 109, 2012
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2LOH
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2LMO
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