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PDB: 144 results
5EA7
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Crystal Structure of Inhibitor BMS-433771 in Complex with Prefusion RSV F Glycoprotein
Descriptor: 1-cyclopropyl-3-[[1-(4-oxidanylbutyl)benzimidazol-2-yl]methyl]imidazo[4,5-c]pyridin-2-one, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P.
Deposit date:2015-10-15
Release date:2015-12-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.851 Å)
Cite:Molecular mechanism of respiratory syncytial virus fusion inhibitors.
Nat.Chem.Biol., 12, 2016
3O45
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BU of 3o45 by Molmil
Crystal Structure of 101F Fab Bound to 17-mer Peptide Epitope
Descriptor: Fusion glycoprotein F1, Mouse monoclonal antibody 101F 101F Fab heavy chain, Mouse monoclonal antibody 101F 101F Fab light chain, ...
Authors:McLellan, J.S, Chen, M, Chang, J.S, Yang, Y, Kim, A, Graham, B.S, Kwong, P.D.
Deposit date:2010-07-26
Release date:2010-10-13
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.872 Å)
Cite:Structure of a Major Antigenic Site on the Respiratory Syncytial Virus Fusion Glycoprotein in Complex with Neutralizing Antibody 101F.
J.Virol., 84, 2010
5K6G
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BU of 5k6g by Molmil
Crystal structure of prefusion-stabilized RSV F single-chain 9-24 DS-Cav1 variant.
Descriptor: Fusion glycoprotein F0,Fusion glycoprotein F0
Authors:Joyce, M.G, Zhang, B, Mascola, J.R, Kwong, P.D.
Deposit date:2016-05-24
Release date:2016-09-28
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.
Nat.Struct.Mol.Biol., 23, 2016
6EAE
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BU of 6eae by Molmil
CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT L141W STABILIZED IN THE PREFUSION STATE
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Fusion glycoprotein F0, SULFATE ION
Authors:Battles, M.B, McLellan, J.S.
Deposit date:2018-08-03
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Respiratory Syncytial Virus Fusion Inhibitor Resistance
To be published
7LUE
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BU of 7lue by Molmil
Prefusion RSV F glycoprotein bound by neutralizing site V-directed antibody ADI-14442
Descriptor: Fusion glycoprotein F0, Heavy chain of human antibody Fab ADI-14442, Light chain of human antibody Fab ADI-14442
Authors:Gilman, M.S.A, McLellan, J.S.
Deposit date:2021-02-22
Release date:2021-06-16
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses.
Immunity, 54, 2021
6EAN
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BU of 6ean by Molmil
CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT F488I STABILIZED IN THE PREFUSION STATE
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S.
Deposit date:2018-08-03
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Respiratory Syncytial Virus Fusion Inhibitor Resistance
To be published
8WSQ
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BU of 8wsq by Molmil
A protective human antibody against respiratory syncytial virus by targeting a prefusion epitope across sites IV and V of the viral fusion glycoprotein.
Descriptor: Fusion glycoprotein F0, RV11-H scFv, RV11-L scFv
Authors:Xu, S.Y, Chai, Y.
Deposit date:2023-10-17
Release date:2023-11-15
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A protective human antibody against respiratory syncytial virus by targeting a prefusion epitope across sites IV and V of the viral fusion glycoprotein.
To Be Published
8AQS
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BU of 8aqs by Molmil
BA.4/5 SARS-CoV-2 Spike bound to human ACE2 (local)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike glycoprotein,Fibritin, ...
Authors:Lau, K, Ni, D, Beckert, B, Nazarov, S, Myasnikov, A, Pojer, F, Stahlberg, H, Uchikawa, E.
Deposit date:2022-08-13
Release date:2023-03-01
Last modified:2023-04-19
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range.
Plos Pathog., 19, 2023
5K6I
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BU of 5k6i by Molmil
Crystal structure of prefusion-stabilized RSV F single-chain 9-10 DS-Cav1 A149C-Y458C, S46G-E92D-S215P-K465Q variant.
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, ...
Authors:Joyce, M.G, Zhang, B, Mascola, J.R, Kwong, P.D.
Deposit date:2016-05-24
Release date:2016-08-17
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.92 Å)
Cite:Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.
Nat.Struct.Mol.Biol., 23, 2016
8AQV
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BU of 8aqv by Molmil
BA.2.12.1 SARS-CoV-2 Spike bound to mouse ACE2 (local)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2,Ig gamma-2A chain C region, ...
Authors:Lau, K, Ni, D, Beckert, B, Nazarov, S, Myasnikov, A, Pojer, F, Stahlberg, H, Uchikawa, E.
Deposit date:2022-08-13
Release date:2023-03-01
Last modified:2023-04-19
Method:ELECTRON MICROSCOPY (2.96 Å)
Cite:Cryo-EM structures and binding of mouse and human ACE2 to SARS-CoV-2 variants of concern indicate that mutations enabling immune escape could expand host range.
Plos Pathog., 19, 2023
5K6B
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BU of 5k6b by Molmil
Crystal structure of prefusion-stabilized RSV F single-chain 9 DS-Cav1 variant.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, SULFATE ION
Authors:Joyce, M.G, Zhang, B, Rundlet, E.J, Mascola, J.R, Kwong, P.D.
Deposit date:2016-05-24
Release date:2016-08-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.981 Å)
Cite:Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.
Nat.Struct.Mol.Biol., 23, 2016
4MMU
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BU of 4mmu by Molmil
Crystal Structure of Prefusion-stabilized RSV F Variant DS-Cav1 at pH 5.5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F1 fused with Fibritin trimerization domain, Fusion glycoprotein F2, ...
Authors:Joyce, M.G, Mclellan, J.S, Stewart-Jones, G.B.E, Sastry, M, Yang, Y, Graham, B.S, Kwong, P.D.
Deposit date:2013-09-09
Release date:2013-11-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.
Science, 342, 2013
6EAH
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BU of 6eah by Molmil
CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT K394R-S398L STABILIZED IN THE PREFUSION STATE
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S.
Deposit date:2018-08-03
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis for Respiratory Syncytial Virus Fusion Inhibitor Resistance
To be published
6EAF
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BU of 6eaf by Molmil
CRYSTAL STRUCTURE OF HUMAN RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN INHIBITOR ESCAPE VARIANT G143S STABILIZED IN THE PREFUSION STATE
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0, ...
Authors:Battles, M.B, McLellan, J.S.
Deposit date:2018-08-03
Release date:2019-08-07
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Basis for Respiratory Syncytial Virus Fusion Inhibitor Resistance
To be published
8CIM
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BU of 8cim by Molmil
BA.2-07 FAB IN COMPLEX WITH SARS-COV-2 BA.2.12.1 SPIKE GLYCOPROTEIN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BA.2-07 FAB HEAVY CHAIN, ...
Authors:Duyvesteyn, H.M.E, Ren, J, Stuart, D.I, Fry, E.E.
Deposit date:2023-02-10
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Isolation of a pair of potent broadly neutralizing mAb binding to RBD and SD1 domains of SARS-CoV-2
Res Sq, 2023
6APB
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BU of 6apb by Molmil
Crystal Structure of Non-Neutralizing Infant Antibody ADI-14359 in Complex with Postfusion RSV F Glycoprotein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, ADI-14359 Fab Light Chain, Fusion glycoprotein F0,Fusion glycoprotein F0, ...
Authors:Gilman, M.S.A, McLellan, J.S.
Deposit date:2017-08-17
Release date:2018-03-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Infants Infected with Respiratory Syncytial Virus Generate Potent Neutralizing Antibodies that Lack Somatic Hypermutation.
Immunity, 48, 2018
4MMT
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BU of 4mmt by Molmil
Crystal Structure of Prefusion-stabilized RSV F Variant DS-Cav1 at pH 9.5
Descriptor: Fusion glycoprotein F1 fused with Fibritin trimerization domain, Fusion glycoprotein F2
Authors:Joyce, M.G, Mclellan, J.S, Stewart-Jones, G.B.E, Sastry, M, Yang, Y, Graham, B.S, Kwong, P.D.
Deposit date:2013-09-09
Release date:2013-11-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.
Science, 342, 2013
5EA5
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BU of 5ea5 by Molmil
Crystal Structure of Inhibitor TMC-353121 in Complex with Prefusion RSV F Glycoprotein
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-[[6-[[[2-(3-hydroxypropyl)-5-methylphenyl]amino]methyl]-2-[[3-(4-morpholinyl)propyl]amino]-1H-benzimidazol-1-yl]methyl]-6-methyl-3-pyridinol, D(-)-TARTARIC ACID, ...
Authors:Battles, M.B, McLellan, J.S, Arnoult, E, Roymans, D, Langedijk, J.P.
Deposit date:2015-10-15
Release date:2015-12-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Molecular mechanism of respiratory syncytial virus fusion inhibitors.
Nat.Chem.Biol., 12, 2016
8H3E
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BU of 8h3e by Molmil
Complex structure of a small molecule (SPC-14) bound SARS-CoV-2 spike protein, closed state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-(6-nitro-2,3-dihydroindol-1-yl)-7-oxidanylidene-heptanoic acid, Spike glycoprotein,Fibritin
Authors:Meng, F, Wang, Q, Xie, Y, Ni, X, Huang, N.
Deposit date:2022-10-08
Release date:2023-03-22
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:In Silico Discovery of Small Molecule Modulators Targeting the Achilles' Heel of SARS-CoV-2 Spike Protein.
Acs Cent.Sci., 9, 2023
5U68
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BU of 5u68 by Molmil
Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus
Descriptor: Chimera protein of Fusion glycoprotein F0 and Envelope glycoprotein, MPE8
Authors:Wen, X, Jardetzky, T.S.
Deposit date:2016-12-07
Release date:2017-02-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.083 Å)
Cite:Structural basis for antibody cross-neutralization of respiratory syncytial virus and human metapneumovirus.
Nat Microbiol, 2, 2017
4MMR
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BU of 4mmr by Molmil
Crystal Structure of Prefusion-stabilized RSV F Variant Cav1 at pH 9.5
Descriptor: Fusion glycoprotein F1 fused with Fibritin trimerization domain, Fusion glycoprotein F2
Authors:Stewart-Jones, G.B.E, McLellan, J.S, Joyce, M.G, Sastry, M, Yang, Y, Graham, B.S, Kwong, P.D.
Deposit date:2013-09-09
Release date:2013-11-20
Last modified:2021-06-02
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-based design of a fusion glycoprotein vaccine for respiratory syncytial virus.
Science, 342, 2013
7Z85
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BU of 7z85 by Molmil
CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11-B5 nanobody complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody H11-B5, ...
Authors:Weckener, M, Naismith, J.H.
Deposit date:2022-03-16
Release date:2022-07-13
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes.
Proc.Natl.Acad.Sci.USA, 119, 2022
7Z6V
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BU of 7z6v by Molmil
CRYO-EM STRUCTURE OF SARS-COV-2 SPIKE : H11 nanobody complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Nanobody H11, ...
Authors:Weckener, M, Naismith, J.H, Vogirala, V.K.
Deposit date:2022-03-14
Release date:2022-07-13
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Correlation between the binding affinity and the conformational entropy of nanobody SARS-CoV-2 spike protein complexes.
Proc.Natl.Acad.Sci.USA, 119, 2022
7ZJ8
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BU of 7zj8 by Molmil
X-31 Hemagglutinin Precursor HA0 at pH 7.5 after reneutralization
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin,Fibritin, ...
Authors:Garcia-Moro, E, Rosenthal, P.B.
Deposit date:2022-04-08
Release date:2022-08-17
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Reversible structural changes in the influenza hemagglutinin precursor at membrane fusion pH.
Proc.Natl.Acad.Sci.USA, 119, 2022
7TN1
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BU of 7tn1 by Molmil
Multistate design to stabilize viral class I fusion proteins
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fusion glycoprotein F0
Authors:Huang, J, Banerjee, A, Gonzalez, K, Mousa, J, Strauch, E.
Deposit date:2022-01-20
Release date:2023-07-12
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Multistate design to stabilize viral class I fusion proteins
To Be Published

221716

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