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PDB: 81 results
6WOY
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BU of 6woy by Molmil
Thermus thermophilus RNA polymerase initially transcribing complex with 3'dCTP
Descriptor: 3'-DEOXY-CYTIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*G)-3'), ...
Authors:Shin, Y, Murakami, K.S.
Deposit date:2020-04-26
Release date:2020-06-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3 Å)
Cite:The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases.
Nat Commun, 12, 2021
3DXJ
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BU of 3dxj by Molmil
Crystal structure of thermus thermophilus rna polymerase holoenzyme in complex with the antibiotic myxopyronin
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, BACTERIAL RNA POLYMERASE BETA SUBUNIT; CHAIN C, M, ...
Authors:Das, K, Arnold, E.
Deposit date:2008-07-24
Release date:2008-10-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:The RNA polymerase "switch region" is a target for inhibitors.
Cell(Cambridge,Mass.), 135, 2008
5D4D
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BU of 5d4d by Molmil
Crystal structure of Thermus thermophilus product complex for transcription initiation with NAD and CTP
Descriptor: ADENOSINE MONOPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ...
Authors:Zhang, Y, Ebright, R.H.
Deposit date:2015-08-07
Release date:2016-07-06
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA.
Nature, 535, 2016
7RDQ
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BU of 7rdq by Molmil
Cryo-EM structure of Thermus thermophilus reiterative transcription complex with 11nt oligo-G RNA
Descriptor: DNA (31-MER) nontemplate strand, DNA (31-MER) template strand, DNA-directed RNA polymerase subunit alpha, ...
Authors:Liu, Y, Ebright, R.H.
Deposit date:2021-07-10
Release date:2022-02-02
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural and mechanistic basis of reiterative transcription initiation.
Proc.Natl.Acad.Sci.USA, 119, 2022
2O5J
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BU of 2o5j by Molmil
Crystal structure of the T. thermophilus RNAP polymerase elongation complex with the NTP substrate analog
Descriptor: 5'-D(*AP*AP*CP*GP*CP*CP*AP*GP*AP*CP*AP*GP*GP*G)-3', 5'-D(P*CP*CP*CP*TP*GP*TP*CP*TP*GP*GP*CP*GP*TP*TP*CP*GP*CP*GP*CP*GP*CP*CP*G)-3', 5'-R(P*GP*AP*GP*UP*CP*UP*GP*CP*GP*GP*CP*GP*CP*GP*CP*G)-3', ...
Authors:Vassylyev, D.G, Vassylyeva, M.N.
Deposit date:2006-12-06
Release date:2007-07-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for substrate loading in bacterial RNA polymerase.
Nature, 448, 2007
5TMF
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BU of 5tmf by Molmil
Re-refinement of thermus thermophilus RNA polymerase
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Wang, J.
Deposit date:2016-10-12
Release date:2016-11-23
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3 Å)
Cite:On the validation of crystallographic symmetry and the quality of structures.
Protein Sci., 24, 2015
2PPB
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BU of 2ppb by Molmil
Crystal structure of the T. thermophilus RNAP polymerase elongation complex with the ntp substrate analog and antibiotic streptolydigin
Descriptor: DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, DNA (5'-D(*AP*AP*CP*GP*CP*CP*AP*GP*AP*CP*AP*GP*GP*G)-3'), DNA (5'-D(P*CP*CP*CP*TP*GP*TP*CP*TP*GP*GP*CP*GP*TP*TP*CP*GP*CP*GP*CP*GP*CP*CP*G)-3'), ...
Authors:Vassylyev, D.G, Vassylyeva, M.N, Artsimovitch, I, Landick, R.
Deposit date:2007-04-28
Release date:2007-07-17
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis for substrate loading in bacterial RNA polymerase.
Nature, 448, 2007
1ZYR
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BU of 1zyr by Molmil
Structure of Thermus thermophilus RNA polymerase holoenzyme in complex with the antibiotic streptolydigin
Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase omega chain, ...
Authors:Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E.
Deposit date:2005-06-10
Release date:2005-09-13
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation.
Cell(Cambridge,Mass.), 122, 2005
4Q5S
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BU of 4q5s by Molmil
Thermus thermophilus RNA polymerase initially transcribing complex containing 6-mer RNA
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*GP*CP*CP*A)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3'), ...
Authors:Murakami, K.S.
Deposit date:2014-04-17
Release date:2014-07-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural basis of transcription initiation by bacterial RNA polymerase holoenzyme.
J.Biol.Chem., 289, 2014
6OY7
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BU of 6oy7 by Molmil
X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter at 7 min
Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*TP*CP*TP*GP*AP*TP*GP*CP*AP*GP*G)-3'), DNA (5'-D(P*CP*CP*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ...
Authors:Shin, Y, Murakami, K.S.
Deposit date:2019-05-14
Release date:2019-07-24
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase.
Nucleic Acids Res., 48, 2020
6P70
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BU of 6p70 by Molmil
X-ray crystal structure of bacterial RNA polymerase and pyrBI promoter complex
Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*CP*GP*AP*TP*CP*TP*TP*TP*GP*CP*CP*GP*GP*G)-3'), DNA (5'-D(P*TP*CP*CP*CP*GP*GP*CP*AP*AP*AP*TP*TP*GP*TP*CP*CP*G)-3'), DNA-directed RNA polymerase subunit alpha, ...
Authors:Shin, Y, Murakami, K.S.
Deposit date:2019-06-04
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.052 Å)
Cite:Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase.
Nucleic Acids Res., 48, 2020
5D4E
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BU of 5d4e by Molmil
Crystal structure of Thermus thermophilus product complex for transcription initiation with 3'-dephosphate-CoA and CTP
Descriptor: CYTIDINE-5'-MONOPHOSPHATE, DEPHOSPHO COENZYME A, DIPHOSPHATE, ...
Authors:Zhang, Y, Ebright, R.H.
Deposit date:2015-08-07
Release date:2016-07-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA.
Nature, 535, 2016
6OY6
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BU of 6oy6 by Molmil
X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter at 5 min
Descriptor: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*GP*AP*TP*CP*TP*GP*AP*TP*GP*CP*AP*GP*G)-3'), DNA (5'-D(P*CP*CP*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ...
Authors:Shin, Y, Murakami, K.S.
Deposit date:2019-05-14
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.096 Å)
Cite:Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase.
Nucleic Acids Res., 48, 2020
6OY5
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BU of 6oy5 by Molmil
X-ray crystal structure of a bacterial reiterative transcription complex of pyrG promoter at 3 min
Descriptor: DNA (5'-D(*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*CP*TP*CP*TP*GP*AP*TP*GP*CP*AP*G)-3'), DNA (5'-D(P*CP*CP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*AP*T)-3'), DNA-directed RNA polymerase subunit alpha, ...
Authors:Shin, Y, Murakami, K.S.
Deposit date:2019-05-14
Release date:2019-06-05
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural basis of reiterative transcription from the pyrG and pyrBI promoters by bacterial RNA polymerase.
Nucleic Acids Res., 48, 2020
4OIO
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BU of 4oio by Molmil
Crystal structure of Thermus thermophilus pre-insertion substrate complex for de novo transcription initiation
Descriptor: 5'-D(*CP*CP*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', 5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]cytidine, ...
Authors:Zhang, Y, Ebright, R.H, Arnold, E.
Deposit date:2014-01-20
Release date:2014-05-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
6M6C
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BU of 6m6c by Molmil
CryoEM structure of Thermus thermophilus RNA polymerase elongation complex
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Shi, J, Wen, A, Feng, Y.
Deposit date:2020-03-14
Release date:2020-10-14
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of Mfd-dependent transcription termination.
Nucleic Acids Res., 48, 2020
4OIR
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BU of 4oir by Molmil
Crystal structure of Thermus thermophilus RNA polymerase transcription initiation complex soaked with GE23077 and rifamycin SV
Descriptor: (2Z)-2-methylbut-2-enoic acid, 5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3', 5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G)-3', ...
Authors:Zhang, Y, Ebright, R.H, Arnold, E.
Deposit date:2014-01-20
Release date:2014-05-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.105 Å)
Cite:GE23077 binds to the RNA polymerase 'i' and 'i+1' sites and prevents the binding of initiating nucleotides.
Elife, 3, 2014
6L74
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BU of 6l74 by Molmil
Thermus thermophilus initial transcription complex comprising sigma A and 5'-triphosphate RNA of 2 nt
Descriptor: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ...
Authors:Zhang, Y, Li, L, Ebright, R.H.
Deposit date:2019-10-31
Release date:2020-03-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
6WOX
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BU of 6wox by Molmil
Thermus thermophilus RNA polymerase initially transcribing complex with 2'dCTP
Descriptor: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*TP*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*GP*CP*AP*G)-3'), ...
Authors:Shin, Y, Murakami, K.S.
Deposit date:2020-04-26
Release date:2020-06-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:The mechanism of the nucleo-sugar selection by multi-subunit RNA polymerases.
Nat Commun, 12, 2021
6KQH
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BU of 6kqh by Molmil
Thermus thermophilus initial transcription complex comprising sigma A and 5'-OH RNA of 7 nt
Descriptor: DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ...
Authors:Zhang, Y, Li, L, Ebright, R.H.
Deposit date:2019-08-17
Release date:2020-03-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
6KQM
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BU of 6kqm by Molmil
Thermus thermophilus initial transcription complex comprising sigma A and 5'-triphosphate RNA of 5 nt
Descriptor: DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), DNA-directed RNA polymerase subunit alpha, ...
Authors:Zhang, Y, Li, L, Ebright, R.H.
Deposit date:2019-08-18
Release date:2020-03-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (3.197 Å)
Cite:RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
5E17
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BU of 5e17 by Molmil
T. thermophilus transcription initiation complex having a RRR discriminator sequence and a nontemplate-strand length corresponding to TSS selection at position 7 (RPo-GGG-7)
Descriptor: DNA (27-MER), DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*GP*AP*GP*GP*G)-3'), DNA-directed RNA polymerase subunit alpha, ...
Authors:Zhang, Y, Ebright, R.H.
Deposit date:2015-09-29
Release date:2016-03-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Multiplexed protein-DNA cross-linking: Scrunching in transcription start site selection.
Science, 351, 2016
8HSG
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BU of 8hsg by Molmil
Thermus thermophilus RNA polymerase elongation complex
Descriptor: DNA (27-MER), DNA (37-MER), DNA-directed RNA polymerase subunit alpha, ...
Authors:Murayama, Y, Ehara, H, Sekine, S.
Deposit date:2022-12-19
Release date:2023-05-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis of the transcription termination factor Rho engagement with transcribing RNA polymerase from Thermus thermophilus.
Sci Adv, 9, 2023
5D4C
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BU of 5d4c by Molmil
Crystal structure of Thermus thermophilus product complex for transcription initiation with ATP and CTP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CYTIDINE-5'-MONOPHOSPHATE, CYTIDINE-5'-TRIPHOSPHATE, ...
Authors:Zhang, Y, Ebright, R.H.
Deposit date:2015-08-07
Release date:2016-07-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.28 Å)
Cite:The mechanism of RNA 5' capping with NAD(+), NADH and desphospho-CoA.
Nature, 535, 2016
2CW0
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BU of 2cw0 by Molmil
Crystal structure of Thermus thermophilus RNA polymerase holoenzyme at 3.3 angstroms resolution
Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Tuske, S, Sarafianos, S.G, Wang, X, Hudson, B, Sineva, E, Mukhopadhyay, J, Birktoft, J.J, Leroy, O, Ismail, S, Clark Jr, A.D, Dharia, C, Napoli, A, Laptenko, O, Lee, J, Borukhov, S, Ebright, R.H, Arnold, E.
Deposit date:2005-06-15
Release date:2005-09-20
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation
Cell(Cambridge,Mass.), 122, 2005

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