7XPN
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7YG1
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![BU of 7yg1 by Molmil](/molmil-images/mine/7yg1) | Cryo-EM structure of the C-terminal domain of the human sodium-chloride cotransporter | Descriptor: | Solute carrier family 12 member 3 | Authors: | Nan, J, Yang, X.M, Shan, Z.Y, Yuan, Y.F, Zhang, Y.Q. | Deposit date: | 2022-07-09 | Release date: | 2022-11-23 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.77 Å) | Cite: | Cryo-EM structure of the human sodium-chloride cotransporter NCC. Sci Adv, 8, 2022
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7Y6I
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![BU of 7y6i by Molmil](/molmil-images/mine/7y6i) | Cryo-EM structure of human sodium-chloride cotransporter | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Nan, J, Yang, X, Shan, Z, Yuan, Y, Zhang, Y.Q. | Deposit date: | 2022-06-20 | Release date: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Cryo-EM structure of the human sodium-chloride cotransporter NCC. Sci Adv, 8, 2022
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7YG0
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![BU of 7yg0 by Molmil](/molmil-images/mine/7yg0) | Cryo-EM structure of human sodium-chloride cotransporter | Descriptor: | Solute carrier family 12 member 3 | Authors: | Nan, J, Yang, X.M, Shan, Z.Y, Yuan, Y.F, Zhang, Y.Q. | Deposit date: | 2022-07-09 | Release date: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (3.75 Å) | Cite: | Cryo-EM structure of the human sodium-chloride cotransporter NCC. Sci Adv, 8, 2022
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6KCV
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![BU of 6kcv by Molmil](/molmil-images/mine/6kcv) | Structure of alginate lyase Aly36B mutant K143A/Y185A in complex with alginate tetrasaccharide | Descriptor: | Alginate lyase, CALCIUM ION, beta-D-mannopyranuronic acid-(1-4)-beta-D-mannopyranuronic acid-(1-4)-beta-D-mannopyranuronic acid-(1-4)-beta-D-mannopyranuronic acid | Authors: | Dong, F, Zhang, Y.Z, Chen, X.L. | Deposit date: | 2019-06-29 | Release date: | 2020-06-24 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.282 Å) | Cite: | Alginate Lyase Aly36B is a New Bacterial Member of the Polysaccharide Lyase Family 36 and Catalyzes by a Novel Mechanism With Lysine as Both the Catalytic Base and Catalytic Acid. J.Mol.Biol., 431, 2019
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6L94
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![BU of 6l94 by Molmil](/molmil-images/mine/6l94) | The structure of the dioxygenase ABH1 from mouse | Descriptor: | FE (II) ION, Nucleic acid dioxygenase ALKBH1 | Authors: | Xie, W, Wang, C, Li, H, Zhang, Y. | Deposit date: | 2019-11-08 | Release date: | 2020-11-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.10012341 Å) | Cite: | ALKBH1 promotes lung cancer by regulating m6A RNA demethylation. Biochem Pharmacol, 189, 2021
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6IVO
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![BU of 6ivo by Molmil](/molmil-images/mine/6ivo) | Crystal structure of a membrane protein P208A | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, CHLORIDE ION, ... | Authors: | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | Deposit date: | 2018-12-04 | Release date: | 2019-11-06 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations. Commun Biol, 2, 2019
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6IVQ
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![BU of 6ivq by Molmil](/molmil-images/mine/6ivq) | Crystal structure of a membrane protein S19A | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, CHLORIDE ION, ... | Authors: | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | Deposit date: | 2018-12-04 | Release date: | 2019-11-06 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations. Commun Biol, 2, 2019
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7DTY
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![BU of 7dty by Molmil](/molmil-images/mine/7dty) | Structural basis of ligand selectivity conferred by the human glucose-dependent insulinotropic polypeptide receptor | Descriptor: | CHOLESTEROL, Gastric inhibitory polypeptide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhao, F.H, Zhang, C, Zhou, Q.T, Hang, K.N, Zou, X.Y, Chen, Y, Wu, F, Rao, Q.D, Dai, A.T, Yin, W.C, Shen, D.D, Zhang, Y, Xia, T, Stevens, R.C, Xu, H.E, Yang, D.H, Zhao, L.H, Wang, M.W. | Deposit date: | 2021-01-06 | Release date: | 2021-08-04 | Last modified: | 2021-08-11 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor. Elife, 10, 2021
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6IVP
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![BU of 6ivp by Molmil](/molmil-images/mine/6ivp) | Crystal structure of a membrane protein P262A | Descriptor: | CHLORIDE ION, ZINC ION, bestrophin | Authors: | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | Deposit date: | 2018-12-04 | Release date: | 2019-11-06 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (3.8 Å) | Cite: | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations. Commun Biol, 2, 2019
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6IVN
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![BU of 6ivn by Molmil](/molmil-images/mine/6ivn) | Crystal structure of a membrane protein G264A | Descriptor: | CHLORIDE ION, GLUTAMIC ACID, Ibestrophin, ... | Authors: | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | Deposit date: | 2018-12-04 | Release date: | 2019-11-06 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations. Commun Biol, 2, 2019
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8HYJ
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6IVL
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![BU of 6ivl by Molmil](/molmil-images/mine/6ivl) | Crystal structure of a membrane protein L259A | Descriptor: | ACETIC ACID, CHLORIDE ION, Ibestrophin, ... | Authors: | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | Deposit date: | 2018-12-04 | Release date: | 2019-11-06 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations. Commun Biol, 2, 2019
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6IVJ
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![BU of 6ivj by Molmil](/molmil-images/mine/6ivj) | Crystal structure of a membrane protein G18A | Descriptor: | ACETIC ACID, CHLORIDE ION, Ibestrophin, ... | Authors: | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | Deposit date: | 2018-12-04 | Release date: | 2019-11-06 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.77 Å) | Cite: | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations. Commun Biol, 2, 2019
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7X8R
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![BU of 7x8r by Molmil](/molmil-images/mine/7x8r) | Cryo-EM structure of the Boc5-bound hGLP-1R-Gs complex | Descriptor: | 2,4-bis(3-methoxy-4-thiophen-2-ylcarbonyloxy-phenyl)-1,3-bis[[4-[(2-methylpropan-2-yl)oxycarbonylamino]phenyl]carbonylamino]cyclobutane-1,3-dicarboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Cong, Z.T, Zhou, Q.T, Li, Y, Chen, L.N, Zhang, Z.C, Liang, A.Y, Liu, Q, Wu, X.Y, Dai, A.T, Xia, T, Wu, W, Zhang, Y, Yang, D.H, Wang, M.W. | Deposit date: | 2022-03-14 | Release date: | 2022-06-29 | Method: | ELECTRON MICROSCOPY (2.61 Å) | Cite: | Structural basis of peptidomimetic agonism revealed by small- molecule GLP-1R agonists Boc5 and WB4-24. Proc.Natl.Acad.Sci.USA, 119, 2022
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7X8S
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![BU of 7x8s by Molmil](/molmil-images/mine/7x8s) | Cryo-EM structure of the WB4-24-bound hGLP-1R-Gs complex | Descriptor: | 2,4-bis(3-methoxy-4-thiophen-2-ylcarbonyloxy-phenyl)-1,3-bis[[4-(2-methylpropanoylamino)phenyl]carbonylamino]cyclobutane-1,3-dicarboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Cong, Z.T, Zhou, Q.T, Li, Y, Chen, L.N, Zhang, Z.C, Liang, A.Y, Liu, Q, Wu, X.Y, Dai, A.T, Xia, T, Wu, W, Zhang, Y, Yang, D.H, Wang, M.W. | Deposit date: | 2022-03-14 | Release date: | 2022-06-29 | Method: | ELECTRON MICROSCOPY (3.09 Å) | Cite: | Structural basis of peptidomimetic agonism revealed by small- molecule GLP-1R agonists Boc5 and WB4-24. Proc.Natl.Acad.Sci.USA, 119, 2022
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6JIX
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![BU of 6jix by Molmil](/molmil-images/mine/6jix) | The cyrstal structure of taurine:2-oxoglutarate aminotransferase from Bifidobacterium kashiwanohense, in complex with PLP and glutamate | Descriptor: | GLUTAMIC ACID, PYRIDOXAL-5'-PHOSPHATE, taurine:2-oxoglutarate aminotransferase | Authors: | Li, M, Lin, L, Zhang, Y, Yuchi, Z. | Deposit date: | 2019-02-23 | Release date: | 2020-01-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.647 Å) | Cite: | Biochemical and structural investigation of taurine:2-oxoglutarate aminotransferase fromBifidobacterium kashiwanohense. Biochem.J., 476, 2019
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8JD9
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![BU of 8jd9 by Molmil](/molmil-images/mine/8jd9) | Cyro-EM structure of the Na+/H+ antipoter SOS1 from Arabidopsis thaliana,class1 | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Sodium/hydrogen exchanger 7 | Authors: | Yang, G.H, Zhang, Y.M, Zhou, J.Q, Jia, Y.T, Xu, X, Fu, P, Wu, H.Y. | Deposit date: | 2023-05-13 | Release date: | 2023-11-08 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.87 Å) | Cite: | Structural basis for the activity regulation of Salt Overly Sensitive 1 in Arabidopsis salt tolerance. Nat.Plants, 9, 2023
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8JDA
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![BU of 8jda by Molmil](/molmil-images/mine/8jda) | Cyro-EM structure of the Na+/H+ antipoter SOS1 from Arabidopsis thaliana,class2 | Descriptor: | Sodium/hydrogen exchanger 7 | Authors: | Yang, G.H, Zhang, Y.M, Zhou, J.Q, Jia, Y.T, Xu, X, Fu, P, Wu, H.Y. | Deposit date: | 2023-05-13 | Release date: | 2023-11-08 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.67 Å) | Cite: | Structural basis for the activity regulation of Salt Overly Sensitive 1 in Arabidopsis salt tolerance. Nat.Plants, 9, 2023
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7EU0
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![BU of 7eu0 by Molmil](/molmil-images/mine/7eu0) | The cryo-EM structure of A. thaliana Pol IV-RDR2 backtracked complex | Descriptor: | DNA (33-MER), DNA (5'-D(*CP*TP*GP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*GP*AP*GP*TP*G)-3'), DNA-directed RNA polymerase IV subunit 1, ... | Authors: | Fang, C.L, Wu, X.X, Huang, K, Zhang, Y. | Deposit date: | 2021-05-15 | Release date: | 2021-12-29 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Pol IV and RDR2: A two-RNA-polymerase machine that produces double-stranded RNA. Science, 374, 2021
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7EVJ
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![BU of 7evj by Molmil](/molmil-images/mine/7evj) | Crystal structure of CBP bromodomain liganded with 9c | Descriptor: | 3-acetyl-1-((3-(1-cyclopropyl-1H-pyrazol-4-yl)-2-fluoro-5-(hydroxymethyl)phenyl)carbamoyl)indolizin-7-yl dimethylcarbamate, CREB-binding protein, GLYCEROL, ... | Authors: | Xiang, Q, Wang, C, Wu, T, Zhang, Y, Zhang, C, Luo, G, Wu, X, Shen, H, Xu, Y. | Deposit date: | 2021-05-21 | Release date: | 2022-02-16 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Design, Synthesis, and Biological Evaluation of 1-(Indolizin-3-yl)ethan-1-ones as CBP Bromodomain Inhibitors for the Treatment of Prostate Cancer. J.Med.Chem., 65, 2022
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6IVM
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![BU of 6ivm by Molmil](/molmil-images/mine/6ivm) | Crystal structure of a membrane protein P143A | Descriptor: | 1,2-ETHANEDIOL, ACETIC ACID, CHLORIDE ION, ... | Authors: | Kittredge, A, Fukuda, F, Zhang, Y, Yang, T. | Deposit date: | 2018-12-04 | Release date: | 2019-11-06 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Dual Ca2+-dependent gates in human Bestrophin1 underlie disease-causing mechanisms of gain-of-function mutations. Commun Biol, 2, 2019
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6K81
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![BU of 6k81 by Molmil](/molmil-images/mine/6k81) | Crystal structure of human VASH1-SVBP complex | Descriptor: | Small vasohibin-binding protein, Tubulinyl-Tyr carboxypeptidase 1 | Authors: | Liu, X, Wang, H, Zhang, Y, Feng, Y. | Deposit date: | 2019-06-11 | Release date: | 2020-02-19 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Structural insights into tubulin detyrosination by vasohibins-SVBP complex. Cell Discov, 5, 2019
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7E33
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![BU of 7e33 by Molmil](/molmil-images/mine/7e33) | Serotonin 1E (5-HT1E) receptor-Gi protein complex | Descriptor: | 3-(1-methylpiperidin-4-yl)-1H-indol-5-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, P, Huang, S, Zhang, H, Mao, C, Zhou, X.E, Shen, D.D, Jiang, Y, Zhang, Y, Xu, H.E. | Deposit date: | 2021-02-07 | Release date: | 2021-04-14 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structural insights into the lipid and ligand regulation of serotonin receptors. Nature, 592, 2021
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7E2Y
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![BU of 7e2y by Molmil](/molmil-images/mine/7e2y) | Serotonin-bound Serotonin 1A (5-HT1A) receptor-Gi protein complex | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, P, Huang, S, Zhang, H, Mao, C, Zhou, X.E, Shen, D.D, Jiang, Y, Zhang, Y, Xu, H.E. | Deposit date: | 2021-02-07 | Release date: | 2021-04-14 | Last modified: | 2021-04-28 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural insights into the lipid and ligand regulation of serotonin receptors. Nature, 592, 2021
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