7X8R

Cryo-EM structure of the Boc5-bound hGLP-1R-Gs complex

Summary for 7X8R

• Entry DOI: 10.2210/pdb7x8r/pdb
• EMDB information: 33057
• Descriptor: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: g protein-coupled receptor, glucagon-like peptide-1 receptor, type 2 diabetes mellitus, peptidomimetic agonism, membrane protein
• Biological source: Bos taurus (cattle); More
• Total number of polymer chains: 5
• Total formula weight: 158643.85

Authors

Cong, Z.T.,Zhou, Q.T.,Li, Y.,Chen, L.N.,Zhang, Z.C.,Liang, A.Y.,Liu, Q.,Wu, X.Y.,Dai, A.T.,Xia, T.,Wu, W.,Zhang, Y.,Yang, D.H.,Wang, M.W. (deposition date: 2022-03-14, release date: 2022-06-29)

• Primary citation: Cong, Z.,Zhou, Q.,Li, Y.,Chen, L.N.,Zhang, Z.C.,Liang, A.,Liu, Q.,Wu, X.,Dai, A.,Xia, T.,Wu, W.,Zhang, Y.,Yang, D.,Wang, M.W.; Structural basis of peptidomimetic agonism revealed by small- molecule GLP-1R agonists Boc5 and WB4-24.; Proc.Natl.Acad.Sci.USA, 119:e2200155119-e2200155119, 2022; PubMed: 35561211; DOI: 10.1073/pnas.2200155119

Experimental method

ELECTRON MICROSCOPY (2.61 Å)