7X8S
Cryo-EM structure of the WB4-24-bound hGLP-1R-Gs complex
Summary for 7X8S
Entry DOI | 10.2210/pdb7x8s/pdb |
EMDB information | 33058 |
Descriptor | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | glucagon-like peptide-1 receptor, type 2 diabetes mellitus, peptidomimetic agonism, membrane protein |
Biological source | Bos taurus (cattle) More |
Total number of polymer chains | 5 |
Total formula weight | 158583.80 |
Authors | Cong, Z.T.,Zhou, Q.T.,Li, Y.,Chen, L.N.,Zhang, Z.C.,Liang, A.Y.,Liu, Q.,Wu, X.Y.,Dai, A.T.,Xia, T.,Wu, W.,Zhang, Y.,Yang, D.H.,Wang, M.W. (deposition date: 2022-03-14, release date: 2022-06-29) |
Primary citation | Cong, Z.,Zhou, Q.,Li, Y.,Chen, L.N.,Zhang, Z.C.,Liang, A.,Liu, Q.,Wu, X.,Dai, A.,Xia, T.,Wu, W.,Zhang, Y.,Yang, D.,Wang, M.W. Structural basis of peptidomimetic agonism revealed by small- molecule GLP-1R agonists Boc5 and WB4-24. Proc.Natl.Acad.Sci.USA, 119:e2200155119-e2200155119, 2022 Cited by PubMed: 35561211DOI: 10.1073/pnas.2200155119 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.09 Å) |
Structure validation
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