3LT4
 
 | | Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant PB4 | | Descriptor: | 2-(2-amino-4-chlorophenoxy)-5-chlorophenol, Enoyl-ACP reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Maity, K, Bhargav, S.P, Surolia, N, Surolia, A, Suguna, K. | | Deposit date: | 2010-02-15 | | Release date: | 2010-06-16 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | X-ray crystallographic analysis of the complexes of enoyl acyl carrier protein reductase of Plasmodium falciparum with triclosan variants to elucidate the importance of different functional groups in enzyme inhibition
Iubmb Life, 62, 2010
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3LT2
 | | Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant T3 | | Descriptor: | 2-(2,4-dichlorophenoxy)-5-(hydroxymethyl)phenol, Enoyl-ACP reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Maity, K, Bhargav, S.P, Surolia, N, Surolia, A, Suguna, K. | | Deposit date: | 2010-02-14 | | Release date: | 2010-06-16 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | X-ray crystallographic analysis of the complexes of enoyl acyl carrier protein reductase of Plasmodium falciparum with triclosan variants to elucidate the importance of different functional groups in enzyme inhibition
Iubmb Life, 62, 2010
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1ZHG
 | | Crystal structure of Beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Plasmodium falciparum | | Descriptor: | beta hydroxyacyl-acyl carrier protein dehydratase | | Authors: | Swarnamukhi, P.L, Sharma, S.K, Surolia, N, Surolia, A, Suguna, K. | | Deposit date: | 2005-04-25 | | Release date: | 2006-05-30 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of dimeric FabZ of Plasmodium falciparum reveals conformational switching to active hexamers by peptide flips
Febs Lett., 580, 2006
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3LT0
 | | Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant T1 | | Descriptor: | 4-(2,4-dichlorophenoxy)-3-hydroxybenzaldehyde, Enoyl-ACP reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Maity, K, Bhargav, S.P, Sankaran, B, Surolia, N, Surolia, A, Suguna, K. | | Deposit date: | 2010-02-14 | | Release date: | 2010-06-16 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | X-ray crystallographic analysis of the complexes of enoyl acyl carrier protein reductase of Plasmodium falciparum with triclosan variants to elucidate the importance of different functional groups in enzyme inhibition
Iubmb Life, 62, 2010
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3LT1
 | | Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant T2 | | Descriptor: | 5-(chloromethyl)-2-(2,4-dichlorophenoxy)phenol, Enoyl-ACP reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Maity, K, Bhargav, S.P, Sankaran, B, Surolia, N, Surolia, A, Suguna, K. | | Deposit date: | 2010-02-14 | | Release date: | 2010-06-16 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | X-ray crystallographic analysis of the complexes of enoyl acyl carrier protein reductase of Plasmodium falciparum with triclosan variants to elucidate the importance of different functional groups in enzyme inhibition
Iubmb Life, 62, 2010
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3LSY
 | | Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant T0 | | Descriptor: | 3-hydroxy-4-phenoxybenzaldehyde, Enoyl-ACP reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Maity, K, Bhargav, S.P, Surolia, N, Surolia, A, Suguna, K. | | Deposit date: | 2010-02-14 | | Release date: | 2010-06-16 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | X-ray crystallographic analysis of the complexes of enoyl acyl carrier protein reductase of Plasmodium falciparum with triclosan variants to elucidate the importance of different functional groups in enzyme inhibition
Iubmb Life, 62, 2010
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2OKH
 | | Crystal structure of dimeric form of PfFabZ in crystal form3 | | Descriptor: | Beta-hydroxyacyl-ACP dehydratase | | Authors: | Swarnamukhi, P.L, Sharma, S.K, Padala, P, Surolia, N, Surolia, A, Suguna, K. | | Deposit date: | 2007-01-16 | | Release date: | 2007-04-10 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Packing and loop-structure variations in non-isomorphous crystals of FabZ from Plasmodium falciparum
ACTA CRYSTALLOGR.,SECT.D, 63, 2007
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2OKI
 | | Crystal structure of dimeric form of PfFabZ in crystal form2 | | Descriptor: | Beta-hydroxyacyl-ACP dehydratase | | Authors: | Swarnamukhi, P.L, Sharma, S.K, Padala, P, Surolia, N, Surolia, A, Suguna, K. | | Deposit date: | 2007-01-17 | | Release date: | 2007-04-10 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Packing and loop-structure variations in non-isomorphous crystals of FabZ from Plasmodium falciparum
ACTA CRYSTALLOGR.,SECT.D, 63, 2007
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1UH5
 | | Crystal Structure of Enoyl-ACP Reductase with Triclosan at 2.2angstroms | | Descriptor: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN, enoyl-ACP reductase | | Authors: | Swarnamukhi, P.L, Kapoor, M, Surolia, N, Surolia, A, Suguna, K. | | Deposit date: | 2003-06-24 | | Release date: | 2004-09-28 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis for the variation in triclosan affinity to enoyl reductases.
J.Mol.Biol., 343, 2004
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1V35
 | | Crystal Structure of Eoyl-ACP Reductase with NADH | | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, enoyl-ACP reductase | | Authors: | SwarnaMukhi, P.L, Kapoor, M, surolia, N, Surolia, A, Suguna, K. | | Deposit date: | 2003-10-28 | | Release date: | 2004-09-28 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural basis for the variation in triclosan affinity to enoyl reductases.
J.Mol.Biol., 343, 2004
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2FQ0
 | | Solution structure of major conformation of holo-acyl carrier protein from malaria parasite plasmodium falciparum | | Descriptor: | 4'-PHOSPHOPANTETHEINE, acyl carrier protein | | Authors: | Sharma, A.K, Sharma, S.K, Surolia, A, Surolia, N, Sarma, S.P. | | Deposit date: | 2006-01-17 | | Release date: | 2006-08-08 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Solution structures of conformationally equilibrium forms of holo-acyl carrier protein (PfACP) from Plasmodium falciparum provides insight into the mechanism of activation of ACPs
Biochemistry, 45, 2006
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2FQ2
 | | Solution structure of minor conformation of holo-acyl carrier protein from malaria parasite plasmodium falciparum | | Descriptor: | 4'-PHOSPHOPANTETHEINE, acyl carrier protein | | Authors: | Sharma, A.K, Sharma, S.K, Surolia, A, Surolia, N, Sarma, S.P. | | Deposit date: | 2006-01-17 | | Release date: | 2006-08-08 | | Last modified: | 2022-03-09 | | Method: | SOLUTION NMR | | Cite: | Solution structures of conformationally equilibrium forms of holo-acyl carrier protein (PfACP) from Plasmodium falciparum provides insight into the mechanism of activation of ACPs
Biochemistry, 45, 2006
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3AM4
 | | A372M mutant of Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant T1 | | Descriptor: | 4-(2,4-dichlorophenoxy)-3-hydroxybenzaldehyde, Enoyl-ACP reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Maity, K, Banerjee, T, Narayanappa, P, Surolia, N, Surolia, A, Suguna, K. | | Deposit date: | 2010-08-14 | | Release date: | 2011-03-16 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Effect of substrate binding loop mutations on the structure, kinetics, and inhibition of enoyl acyl carrier protein reductase from plasmodium falciparum
Iubmb Life, 63, 2011
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3AM3
 | | A372M mutant of Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan | | Descriptor: | Enoyl-ACP reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN | | Authors: | Maity, K, Banerjee, T, Narayanappa, P, Surolia, N, Surolia, A, Suguna, K. | | Deposit date: | 2010-08-14 | | Release date: | 2011-03-16 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Effect of substrate binding loop mutations on the structure, kinetics, and inhibition of enoyl acyl carrier protein reductase from plasmodium falciparum
Iubmb Life, 63, 2011
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3AM5
 | | K316A mutant of Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan | | Descriptor: | Enoyl-ACP reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN | | Authors: | Maity, K, Banerjee, T, Narayanappa, P, Surolia, N, Surolia, A, Suguna, K. | | Deposit date: | 2010-08-14 | | Release date: | 2011-03-16 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Effect of substrate binding loop mutations on the structure, kinetics, and inhibition of enoyl acyl carrier protein reductase from plasmodium falciparum
Iubmb Life, 63, 2011
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3AZA
 | | Beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Plasmodium falciparum in complex with NAS91-10 | | Descriptor: | 8-(benzyloxy)-5-chloroquinoline, Beta-hydroxyacyl-ACP dehydratase, GLYCEROL | | Authors: | Maity, K, Venkata, B.S, Kapoor, N, Surolia, N, Surolia, A, Suguna, K. | | Deposit date: | 2011-05-21 | | Release date: | 2012-02-29 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Structural basis for the functional and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Plasmodium falciparum
J.Struct.Biol., 176, 2011
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3AZB
 | | Beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Plasmodium falciparum in complex with NAS91-11 | | Descriptor: | 5-chloro-8-[(3-chlorobenzyl)oxy]quinoline, Beta-hydroxyacyl-ACP dehydratase, GLYCEROL | | Authors: | Maity, K, Venkata, B.S, Kapoor, N, Surolia, N, Surolia, A, Suguna, K. | | Deposit date: | 2011-05-21 | | Release date: | 2012-02-29 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural basis for the functional and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Plasmodium falciparum
J.Struct.Biol., 176, 2011
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3AZ9
 | | Beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Plasmodium falciparum in complex with NAS91 | | Descriptor: | 4-chloro-2-[(5-chloroquinolin-8-yl)oxy]phenol, Beta-hydroxyacyl-ACP dehydratase, GLYCEROL, ... | | Authors: | Maity, K, Venkata, B.S, Kapoor, N, Surolia, N, Surolia, A, Suguna, K. | | Deposit date: | 2011-05-21 | | Release date: | 2012-02-29 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.75 Å) | | Cite: | Structural basis for the functional and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Plasmodium falciparum
J.Struct.Biol., 176, 2011
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3AZ8
 | | Beta-Hydroxyacyl-Acyl Carrier Protein Dehydratase (FabZ) from Plasmodium falciparum in complex with NAS21 | | Descriptor: | 4,4,4-trifluoro-1-(4-nitrophenyl)butane-1,3-dione, Beta-hydroxyacyl-ACP dehydratase, CHLORIDE ION, ... | | Authors: | Maity, K, Venkata, B.S, Kapoor, N, Surolia, N, Surolia, A, Suguna, K. | | Deposit date: | 2011-05-20 | | Release date: | 2012-02-29 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structural basis for the functional and inhibitory mechanisms of beta-hydroxyacyl-acyl carrier protein dehydratase (FabZ) of Plasmodium falciparum
J.Struct.Biol., 176, 2011
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