3AM3

A372M mutant of Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan

Summary for 3AM3

• Entry DOI: 10.2210/pdb3am3/pdb
• Related: 1CWU 1UH5 1V35 2AQH 2AQK 3AM4 3AM5 3LT0
• Descriptor: Enoyl-ACP reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TRICLOSAN, ... (4 entities in total)
• Functional Keywords: triclosan, enoyl-acp reductase, mutant, oxidoreductase, p.falciparum, fabi, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Plasmodium falciparum
• Total number of polymer chains: 2
• Total formula weight: 76514.54

Authors

Maity, K.,Banerjee, T.,Narayanappa, P.,Surolia, N.,Surolia, A.,Suguna, K. (deposition date: 2010-08-14, release date: 2011-03-16, Last modification date: 2023-11-01)

• Primary citation: Maity, K.,Banerjee, T.,Prabakaran, N.,Surolia, N.,Surolia, A.,Suguna, K.; Effect of substrate binding loop mutations on the structure, kinetics, and inhibition of enoyl acyl carrier protein reductase from plasmodium falciparum; Iubmb Life, 63:30-41, 2011; PubMed: 21280175; DOI: 10.1002/iub.412

Experimental method

X-RAY DIFFRACTION (2.5 Å)