3AM4

A372M mutant of Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant T1

Summary for 3AM4

Entry DOI	10.2210/pdb3am4/pdb
Related	1CWU 1UH5 1V35 2AQH 2AQK 3AM3 3AM5 3LT0
Descriptor	Enoyl-ACP reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 4-(2,4-dichlorophenoxy)-3-hydroxybenzaldehyde, ... (4 entities in total)
Functional Keywords	triclosan, triclosan variant, enoyl-acp reductase, mutant, oxidoreductase, p.falciparum, fabi, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Plasmodium falciparum
Total number of polymer chains	2
Total formula weight	76501.67
Authors	Maity, K.,Banerjee, T.,Narayanappa, P.,Surolia, N.,Surolia, A.,Suguna, K. (deposition date: 2010-08-14, release date: 2011-03-16, Last modification date: 2023-11-01)
Primary citation	Maity, K.,Banerjee, T.,Prabakaran, N.,Surolia, N.,Surolia, A.,Suguna, K. Effect of substrate binding loop mutations on the structure, kinetics, and inhibition of enoyl acyl carrier protein reductase from plasmodium falciparum Iubmb Life, 63:30-41, 2011 Cited by PubMed: 21280175 DOI: 10.1002/iub.412 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation