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3AM4

A372M mutant of Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant T1

Functional Information from GO Data
ChainGOidnamespacecontents
A0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
A0006633biological_processfatty acid biosynthetic process
B0004318molecular_functionenoyl-[acyl-carrier-protein] reductase (NADH) activity
B0006633biological_processfatty acid biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues28
DetailsBINDING SITE FOR RESIDUE NAD A 801
ChainResidue
AHOH81
ASER170
ASER215
ALEU216
AALA217
AASN218
ALEU265
ATHR266
ALYS285
AALA312
AGLY313
AGLY104
APRO314
ALEU315
ASER317
AALA319
AHOH430
AHOH445
AHOH447
AHOH473
AFT1802
AGLY106
AGLY110
ATYR111
ATRP131
APHE167
AASP168
AALA169

site_idAC2
Number of Residues7
DetailsBINDING SITE FOR RESIDUE FT1 A 802
ChainResidue
AALA217
AALA219
ATYR267
ATYR277
AALA319
APHE368
ANAD801

site_idAC3
Number of Residues22
DetailsBINDING SITE FOR RESIDUE NAD B 901
ChainResidue
BILE105
BGLY106
BGLY110
BTYR111
BTRP131
BPHE167
BASP168
BALA169
BSER170
BLEU216
BALA217
BASN218
BLEU265
BTHR266
BLYS285
BALA312
BGLY313
BPRO314
BLEU315
BSER317
BALA319
BFT1902

site_idAC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE FT1 B 902
ChainResidue
BALA217
BALA219
BTYR267
BTYR277
BALA319
BILE323
BPHE368
BNAD901

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PDB entries from 2024-11-06

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