3LSY

Enoyl-ACP Reductase from Plasmodium falciparum (PfENR) in complex with triclosan variant T0

Summary for 3LSY

Entry DOI	10.2210/pdb3lsy/pdb
Related	1UH5 1V35 1ZSN 1ZXL 2OL4 2OOS 3LT0 3LT1 3LT2 3LT4
Descriptor	Enoyl-ACP reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 3-hydroxy-4-phenoxybenzaldehyde, ... (4 entities in total)
Functional Keywords	triclosan, triclosan variant, enoyl-acp reductase, oxidoreductase, p.falciparum
Biological source	Plasmodium falciparum
Total number of polymer chains	2
Total formula weight	76243.65
Authors	Maity, K.,Bhargav, S.P.,Surolia, N.,Surolia, A.,Suguna, K. (deposition date: 2010-02-14, release date: 2010-06-16, Last modification date: 2023-11-01)
Primary citation	Maity, K.,Bhargav, S.P.,Sankaran, B.,Surolia, N.,Surolia, A.,Suguna, K. X-ray crystallographic analysis of the complexes of enoyl acyl carrier protein reductase of Plasmodium falciparum with triclosan variants to elucidate the importance of different functional groups in enzyme inhibition Iubmb Life, 62:467-476, 2010 Cited by PubMed: 20503440 DOI: 10.1002/iub.327 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.85 Å)

Structure validation