2OL4

Crystal structure of plasmodium falciparum enoyl ACP reductase with triclosan reductase

Summary for 2OL4

Entry DOI	10.2210/pdb2ol4/pdb
Related	1NHD 1NHG 1NHW 1NNU 1ZSN 1ZW1
Descriptor	Enoyl-acyl carrier reductase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, 2-(2,4-DICHLOROPHENOXY)-5-(3-PHENYLPROPYL)PHENOL, ... (4 entities in total)
Functional Keywords	pfenr, malaria, triclosan analog, oxidoreductase
Biological source	Plasmodium falciparum (malaria parasite P. falciparum)
Total number of polymer chains	2
Total formula weight	78772.01
Authors	Tsai, H. (deposition date: 2007-01-18, release date: 2007-07-17, Last modification date: 2023-08-30)
Primary citation	Freundlich, J.S.,Wang, F.,Tsai, H.-C.,Kuo, M.,Shieh, H.-M.,Anderson, J.W.,Nkrumah, L.J.,Valderramos, J.-C.,Yu, M.,Kumar, T.R.S.,Valderramos, S.G.,Jacobs, W.R.,Schiehser, G.A.,Jacobus, D.P.,Fidock, D.A.,Sacchettini, J.C. X-ray structural analysis of Plasmodium falciparum enoyl acyl carrier protein reductase as a pathway toward the optimization of triclosan antimalarial efficacy J.Biol.Chem., 282:25436-25444, 2007 Cited by PubMed: 17567585 DOI: 10.1074/jbc.M701813200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.26 Å)

Structure validation