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PDB: 884 件
2MTP
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BU of 2mtp by Molmil
The structure of Filamin repeat 21 bound to integrin
分子名称: Filamin-A, Integrin alpha-IIb, Integrin beta-3
著者Liu, J, Qin, J.
登録日2014-08-28
公開日2015-04-01
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural mechanism of integrin inactivation by filamin.
Nat.Struct.Mol.Biol., 22, 2015
2LKO
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BU of 2lko by Molmil
Structural Basis of Phosphoinositide Binding to Kindlin-2 Pleckstrin Homology Domain in Regulating Integrin Activation
分子名称: Fermitin family homolog 2, INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE
著者Liu, J, Fukuda, K, Xu, Z.
登録日2011-10-17
公開日2011-10-26
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation.
J.Biol.Chem., 286, 2011
2LSJ
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BU of 2lsj by Molmil
Solution structure of the mouse Rev1 CTD in complex with the Rev1-interacting Region (RIR)of Pol Kappa
分子名称: DNA polymerase kappa, DNA repair protein REV1
著者Liu, J, Wojtaszek, J, Zhou, P.
登録日2012-05-01
公開日2012-06-20
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Multifaceted recognition of vertebrate Rev1 by translesion polymerases zeta and kappa.
J.Biol.Chem., 287, 2012
2LSG
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BU of 2lsg by Molmil
Solution structure of the mouse Rev1 C-terminal domain
分子名称: DNA repair protein REV1
著者Liu, J, Wojtaszek, J, Zhou, P.
登録日2012-04-30
公開日2012-06-20
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Multifaceted recognition of vertebrate Rev1 by translesion polymerases zeta and kappa.
J.Biol.Chem., 287, 2012
4IDT
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BU of 4idt by Molmil
Crystal Structure of NIK with 11-bromo-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-2-amine (T28)
分子名称: 11-bromo-5,6,7,8-tetrahydropyrimido[4',5':3,4]cyclohepta[1,2-b]indol-2-amine, Mitogen-activated protein kinase kinase kinase 14
著者Liu, J, Sudom, A, Wang, Z.
登録日2012-12-13
公開日2013-04-17
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Inhibiting NF-KB-inducing kinase (NIK): Discovery, structure-based design, synthesis, structure activity relationship, and co-crystal structures
Bioorg.Med.Chem.Lett., 23, 2013
5GP7
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BU of 5gp7 by Molmil
Structural basis for the binding between Tankyrase-1 and USP25
分子名称: GLYCEROL, Tankyrase-1, Ubiquitin carboxyl-terminal hydrolase 25
著者Liu, J, Xu, D, Fu, T, Pan, L.
登録日2016-08-01
公開日2017-07-12
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.502 Å)
主引用文献USP25 regulates Wnt signaling by controlling the stability of tankyrases
Genes Dev., 31, 2017
3TCP
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BU of 3tcp by Molmil
Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC569
分子名称: 1-[(trans-4-aminocyclohexyl)methyl]-N-butyl-3-(4-fluorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-6-amine, CALCIUM ION, CHLORIDE ION, ...
著者Liu, J, Yang, C, Simpson, C, DeRyckere, D, Van Deusen, A, Miley, M, Kireev, D.B, Norris-Drouin, J, Sather, S, Hunter, D, Patel, H.S, Janzen, W.P, Machius, M, Johnson, G, Earp, H.S, Graham, D.K, Frye, S, Wang, X.
登録日2011-08-09
公開日2012-06-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Discovery of Novel Small Molecule Mer Kinase Inhibitors for the Treatment of Pediatric Acute Lymphoblastic Leukemia.
ACS Med Chem Lett, 3, 2012
4F0I
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BU of 4f0i by Molmil
Crystal structure of apo TrkA
分子名称: High affinity nerve growth factor receptor
著者Liu, J.
登録日2012-05-04
公開日2012-09-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.302 Å)
主引用文献The Crystal Structures of TrkA and TrkB Suggest Key Regions for Achieving Selective Inhibition.
J.Mol.Biol., 423, 2012
4IDV
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BU of 4idv by Molmil
Crystal Structure of NIK with compound 4-{3-[2-amino-5-(2-methoxyethoxy)pyrimidin-4-yl]-1H-indol-5-yl}-2-methylbut-3-yn-2-ol (13V)
分子名称: 4-{3-[2-amino-5-(2-methoxyethoxy)pyrimidin-4-yl]-1H-indol-5-yl}-2-methylbut-3-yn-2-ol, Mitogen-activated protein kinase kinase kinase 14
著者Liu, J, Sudom, A, Wang, Z.
登録日2012-12-13
公開日2013-04-17
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Inhibiting NF-KB-inducing kinase (NIK): Discovery, structure-based design, synthesis, structure activity relationship, and co-crystal structures
Bioorg.Med.Chem.Lett., 23, 2013
6NE8
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BU of 6ne8 by Molmil
Solution Structure of the Thioredoxin-like Domain of Arabidopsis NCP (NUCLEAR CONTROL OF PEP ACTIVITY)
分子名称: Thioredoxin-like fold domain-containing protein MRL7L, chloroplastic
著者Liu, J, Chen, M, Zhou, P.
登録日2018-12-17
公開日2019-12-25
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches.
Nat Commun, 10, 2019
4FQG
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BU of 4fqg by Molmil
Crystal structure of the TCERG1 FF4-6 tandem repeat domain
分子名称: CHLORIDE ION, NICKEL (II) ION, Transcription elongation regulator 1
著者Liu, J, Fan, S, Lee, C.J, Greenleaf, A.L, Zhou, P.
登録日2012-06-25
公開日2013-02-27
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Specific Interaction of the Transcription Elongation Regulator TCERG1 with RNA Polymerase II Requires Simultaneous Phosphorylation at Ser2, Ser5, and Ser7 within the Carboxyl-terminal Domain Repeat.
J.Biol.Chem., 288, 2013
4HLR
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BU of 4hlr by Molmil
Structural Determinants of Trimerization Specificity in HIV-1 gp41 Protein
分子名称: Gp41, HEXANE-1,6-DIOL
著者Liu, J, Lu, M.
登録日2012-10-17
公開日2013-10-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.57 Å)
主引用文献Structural Determinants of Trimerization Specificity in HIV-1 gp41 Protein
To be Published
2L3T
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BU of 2l3t by Molmil
Solution structure of tandem SH2 domain from Spt6
分子名称: Transcription elongation factor SPT6
著者Liu, J, Zhang, J, Wu, J, Shi, Y.
登録日2010-09-22
公開日2011-06-15
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Solution structure of the tandem SH2 domains from Spt6 and their binding to the phosphorylated RNA polymerase II C-terminal domain
To be Published
7RAM
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BU of 7ram by Molmil
Cryo-EM Structure of the HCMV gHgLgO Trimer Derived from AD169 and TR strains in complex with PDGFRalpha
分子名称: Envelope glycoprotein H, Envelope glycoprotein L, Envelope glycoprotein O, ...
著者Liu, J, Vanarsdall, A.L, Chen, D, Johnson, D.C, Jardetzky, T.S.
登録日2021-07-02
公開日2022-06-08
実験手法ELECTRON MICROSCOPY (3.43 Å)
主引用文献Cryo-Electron Microscopy Structure and Interactions of the Human Cytomegalovirus gHgLgO Trimer with Platelet-Derived Growth Factor Receptor Alpha.
Mbio, 12, 2021
3OXS
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BU of 3oxs by Molmil
Crystal Structure of HLA A*02:07 Bound to HBV Core 18-27
分子名称: 10mer peptide from Pre-core-protein, Beta-2-microglobulin, MHC class I antigen
著者Liu, J, Chen, Y, Lai, L, Ren, E.
登録日2010-09-22
公開日2011-05-04
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural insights into the binding of hepatitis B virus core peptide to HLA-A2 alleles: Towards designing better vaccines.
Eur.J.Immunol., 41, 2011
3U91
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BU of 3u91 by Molmil
Structural Determinants of Trimerization Specificity in HIV-1 gp41 Protein
分子名称: Gp41, O-(O-(2-AMINOPROPYL)-O'-(2-METHOXYETHYL)POLYPROPYLENE GLYCOL 500)
著者Liu, J, Lu, M.
登録日2011-10-17
公開日2013-04-24
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Structural Determinants of Trimerization Specificity in HIV-1 gp41 Protein
To be Published
3OX8
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BU of 3ox8 by Molmil
Crystal Structure of HLA A*02:03 Bound to HBV Core 18-27
分子名称: 10mer peptide from Pre-core-protein, Beta-2-microglobulin, MHC class I antigen
著者Liu, J, Chen, Y, Lai, L, Ren, E.
登録日2010-09-21
公開日2011-05-04
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Structural insights into the binding of hepatitis B virus core peptide to HLA-A2 alleles: Towards designing better vaccines.
Eur.J.Immunol., 41, 2011
3UIA
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BU of 3uia by Molmil
Structural Determinants of Trimerization Specificity in HIV-1 gp41 Protein
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Glycoprotein 41
著者Liu, J, Lu, M.
登録日2011-11-04
公開日2013-05-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Determinants of Trimerization Specificity in HIV-1 gp41 Protein
To be Published
3VC4
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BU of 3vc4 by Molmil
Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
分子名称: (5Z)-5-[3-(trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dione, IMIDAZOLE, Serine/threonine-protein kinase pim-1
著者Liu, J.
登録日2012-01-03
公開日2012-03-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design.
J.Med.Chem., 55, 2012
3VBT
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BU of 3vbt by Molmil
Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
分子名称: 4-chloro-2-(1H-pyrazol-3-yl)phenol, Serine/threonine-protein kinase pim-1
著者Liu, J.
登録日2012-01-02
公開日2012-03-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design.
J.Med.Chem., 55, 2012
3VBV
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Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
分子名称: 8-hydroxyquinoline-2-carboxamide, Serine/threonine-protein kinase pim-1
著者Liu, J.
登録日2012-01-02
公開日2012-03-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design.
J.Med.Chem., 55, 2012
3VBQ
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Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
分子名称: (5~{Z})-5-[[3-[6-[(4-azanylcyclohexyl)amino]pyrazin-2-yl]phenyl]methylidene]-1,3-thiazolidine-2,4-dione, Serine/threonine-protein kinase pim-1
著者Liu, J.
登録日2012-01-02
公開日2012-03-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design.
J.Med.Chem., 55, 2012
3VBY
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Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
分子名称: IMIDAZOLE, Serine/threonine-protein kinase pim-1, furan-2-yl(1H-indol-3-yl)methanone
著者Liu, J.
登録日2012-01-02
公開日2012-03-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design.
J.Med.Chem., 55, 2012
3VBW
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Exploitation of hydrogen bonding constraints and flat hydrophobic energy landscapes in Pim-1 kinase needle screening and inhibitor design
分子名称: 1,3-dioxo-2,3-dihydro-1H-indene-2-carbonitrile, Serine/threonine-protein kinase pim-1
著者Liu, J.
登録日2012-01-02
公開日2012-03-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Implications of promiscuous Pim-1 kinase fragment inhibitor hydrophobic interactions for fragment-based drug design.
J.Med.Chem., 55, 2012
3R00
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The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors
分子名称: 5-bromo-1-benzofuran-2-carboxylic acid, IMIDAZOLE, Proto-oncogene serine/threonine-protein kinase pim-1
著者Liu, J.
登録日2011-03-07
公開日2011-05-11
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011

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