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PDB: 89 件
3SQH
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BU of 3sqh by Molmil
Crystal structure of prethrombin-2 mutant S195A in the the open form
分子名称: Thrombin light chain, heavy chain
著者Pozzi, N, Chen, Z, Di Cera, E.
登録日2011-07-05
公開日2011-11-30
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structures of prethrombin-2 reveal alternative conformations under identical solution conditions and the mechanism of zymogen activation.
Biochemistry, 50, 2011
3MVT
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BU of 3mvt by Molmil
Crystal structure of apo mADA at 2.2A resolution
分子名称: Adenosine deaminase, CHLORIDE ION, GLYCEROL
著者Niu, W, Shu, Q, Chen, Z, Mathews, S, Di Cera, E, Frieden, C.
登録日2010-05-04
公開日2010-10-13
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The role of Zn2+ on the structure and stability of murine adenosine deaminase.
J.Phys.Chem.B, 114, 2010
3MVI
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BU of 3mvi by Molmil
Crystal structure of holo mADA at 1.6 A resolution
分子名称: Adenosine deaminase, GLYCEROL, ZINC ION
著者Niu, W, Shu, Q, Chen, Z, Mathews, S, Di Cera, E, Frieden, C.
登録日2010-05-04
公開日2010-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The role of Zn2+ on the structure and stability of murine adenosine deaminase.
J.Phys.Chem.B, 114, 2010
1SFQ
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BU of 1sfq by Molmil
Fast form of thrombin mutant R(77a)A bound to PPACK
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, SODIUM ION, ...
著者Pineda, A.O, Carrell, C.J, Bush, L.A, Prasad, S, Caccia, S, Chen, Z.W, Mathews, F.S, Di Cera, E.
登録日2004-02-20
公開日2004-06-08
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Molecular dissection of na+ binding to thrombin.
J.Biol.Chem., 279, 2004
4HFP
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BU of 4hfp by Molmil
Structure of thrombin mutant S195a bound to the active site inhibitor argatroban
分子名称: (2R,4R)-4-methyl-1-(N~2~-{[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-arginyl)piperidine-2-carboxylic acid, Prothrombin, SODIUM ION
著者Pozzi, N, Chen, Z, Zapata, F, Lin, W, Barranco-Medina, S, Pelc, L.A, Di Cera, E.
登録日2012-10-05
公開日2013-03-13
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Autoactivation of thrombin precursors.
J.Biol.Chem., 288, 2013
2THF
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BU of 2thf by Molmil
STRUCTURE OF HUMAN ALPHA-THROMBIN Y225F MUTANT BOUND TO D-PHE-PRO-ARG-CHLOROMETHYLKETONE
分子名称: D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, SODIUM ION, THROMBIN HEAVY CHAIN, ...
著者Caccia, S, Futterer, K, Di Cera, E, Waksman, G.
登録日1999-01-26
公開日1999-03-07
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Unexpected crucial role of residue 225 in serine proteases.
Proc.Natl.Acad.Sci.USA, 96, 1999
3BEU
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BU of 3beu by Molmil
Na+-Dependent Allostery Mediates Coagulation Factor Protease Active Site Selectivity
分子名称: BENZAMIDINE, CALCIUM ION, SODIUM ION, ...
著者Page, M.J, Carrell, C.J, Di Cera, E.
登録日2007-11-20
公開日2008-03-11
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献Engineering protein allostery: 1.05 A resolution structure and enzymatic properties of a Na+-activated trypsin.
J.Mol.Biol., 378, 2008
1SG8
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Crystal structure of the procoagulant fast form of thrombin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, thrombin
著者Pineda, A.O, Carrell, C.J, Bush, L.A, Prasad, S, Caccia, S, Chen, Z.W, Mathews, F.S, Di Cera, E.
登録日2004-02-23
公開日2004-06-08
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Molecular dissection of na+ binding to thrombin.
J.Biol.Chem., 279, 2004
1SGI
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BU of 1sgi by Molmil
Crystal structure of the anticoagulant slow form of thrombin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, thrombin
著者Pineda, A.O, Carrell, C.J, Bush, L.A, Prasad, S, Caccia, S, Chen, Z.W, Mathews, F.S, Di Cera, E.
登録日2004-02-23
公開日2004-06-08
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Molecular dissection of na+ binding to thrombin.
J.Biol.Chem., 279, 2004
1T31
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BU of 1t31 by Molmil
A Dual Inhibitor of the Leukocyte Proteases Cathepsin G and Chymase with Therapeutic Efficacy in Animals Models of Inflammation
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-[3-({METHYL[1-(2-NAPHTHOYL)PIPERIDIN-4-YL]AMINO}CARBONYL)-2-NAPHTHYL]-1-(1-NAPHTHYL)-2-OXOETHYLPHOSPHONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者de Garavilla, L, Greco, M.N, Giardino, E.C, Wells, G.I, Haertlein, B.J, Kauffman, J.A, Corcoran, T.W, Derian, C.K, Eckardt, A.J, Abraham, W.M, Sukumar, N, Chen, Z, Pineda, A.O, Mathews, F.S, Di Cera, E, Andrade-Gordon, P, Damiano, B.P, Maryanoff, B.E, Pereira, P.J.B, Wang, Z.M, Rubin, H, Huber, R, Bode, W, Schechter, N.M, Strobl, S.
登録日2004-04-23
公開日2005-03-01
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A novel, potent dual inhibitor of the leukocyte proteases cathepsin G and chymase: molecular mechanisms and anti-inflammatory activity in vivo.
J.Biol.Chem., 280, 2005
3E6P
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BU of 3e6p by Molmil
Crystal structure of human meizothrombin desF1
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, D-PHENYLALANYL-N-[(1S)-4-{[(Z)-AMINO(IMINO)METHYL]AMINO}-1-(CHLOROACETYL)BUTYL]-L-PROLINAMIDE, Prothrombin, ...
著者Papaconstantinou, M.E, Gandhi, P, Chen, Z, Bah, A, Di Cera, E.
登録日2008-08-15
公開日2008-11-18
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Na(+) binding to meizothrombin desF1.
Cell.Mol.Life Sci., 65, 2008
3I77
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BU of 3i77 by Molmil
35/99/170-loops of FXa in SGT
分子名称: ACETATE ION, CALCIUM ION, SULFATE ION, ...
著者Page, M.J, Di Cera, E.
登録日2009-07-08
公開日2010-06-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Combinatorial Enzyme Design Probes Allostery and Cooperativity in the Trypsin Fold.
J.Mol.Biol., 399, 2010
3GIC
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BU of 3gic by Molmil
Structure of thrombin mutant delta(146-149e) in the free form
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombin heavy chain, Thrombin light chain
著者Bah, A, Carrell, C.J, Chen, Z, Gandhi, P.S, Di Cera, E.
登録日2009-03-05
公開日2009-06-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Stabilization of the E* form turns thrombin into an anticoagulant.
J.Biol.Chem., 284, 2009
3I78
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35/99/170/186/220-loops of FXa in SGT
分子名称: BENZAMIDINE, SODIUM ION, SULFATE ION, ...
著者Page, M.J, Di Cera, E.
登録日2009-07-08
公開日2010-06-02
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Combinatorial Enzyme Design Probes Allostery and Cooperativity in the Trypsin Fold.
J.Mol.Biol., 399, 2010
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