4G7R
 
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4G71
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3LA2
 | | Crystal structure of NtcA in complex with 2-oxoglutarate | | 分子名称: | 2-OXOGLUTARIC ACID, Global nitrogen regulator | | 著者 | Zhao, M.X, Jiang, Y.L, He, Y.X, Chen, Y.F, Teng, Y.B, Chen, Y.X, Zhang, C.C, Zhou, C.Z. | | 登録日 | 2010-01-06 | | 公開日 | 2010-07-14 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate.
Proc.Natl.Acad.Sci.USA, 107, 2010
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3LA3
 | | Crystal structure of NtcA in complex with 2,2-difluoropentanedioic acid | | 分子名称: | 2,2-difluoropentanedioic acid, Global nitrogen regulator | | 著者 | Zhao, M.X, Jiang, Y.L, He, Y.X, Chen, Y.F, Teng, Y.B, Chen, Y.X, Zhang, C.C, Zhou, C.Z. | | 登録日 | 2010-01-06 | | 公開日 | 2010-07-14 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for the allosteric control of the global transcription factor NtcA by the nitrogen starvation signal 2-oxoglutarate.
Proc.Natl.Acad.Sci.USA, 107, 2010
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6A3N
 | | Crystal structure of the PDE9 catalytic domain in complex with inhibitor 2 | | 分子名称: | 1-cyclopentyl-6-({(2R)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxopropan-2-yl}amino)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | | 著者 | Wu, Y.N, Zhou, Q, Chen, Y.P, Luo, H.B. | | 登録日 | 2018-06-15 | | 公開日 | 2019-04-10 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia.
J. Med. Chem., 62, 2019
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4G70
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4G7S
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5EJM
 | | ThDP-Mn2+ complex of R413A variant of EcMenD soaked with 2-ketoglutarate for 35 min | | 分子名称: | (4~{R})-4-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl(phosphonooxy)phosphoryl]oxyethyl]-1,3-thiazol-3-ium-2-yl]-4-oxidanyl-butanoic acid, 1,2-ETHANEDIOL, 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase, ... | | 著者 | Song, H.G, Dong, C, Chen, Y.Z, Sun, Y.R, Guo, Z.H. | | 登録日 | 2015-11-02 | | 公開日 | 2016-11-02 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Two active site arginines are critical determinants of substrate binding and catalysis in MenD, a thiamine-dependent enzyme in menaquinone biosynthesis.
Biochem. J., 2018
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3QWA
 | | Crystal structure of Saccharomyces cerevisiae Zeta-crystallin-like quinone oxidoreductase Zta1 | | 分子名称: | Probable quinone oxidoreductase | | 著者 | Guo, P.C, Ma, X.X, Bao, Z.Z, Chen, Y.X, Zhou, C.Z. | | 登録日 | 2011-02-27 | | 公開日 | 2012-02-08 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural insights into the cofactor-assisted substrate recognition of yeast quinone oxidoreductase Zta1
J.Struct.Biol., 176, 2011
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7DTZ
 | | FGFR4 complex with a covalent inhibitor | | 分子名称: | Fibroblast growth factor receptor 4, N-[2-[[5-[[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]methoxy]pyrimidin-2-yl]amino]-3-methyl-phenyl]-2-fluoranyl-prop-2-enamide, SULFATE ION | | 著者 | Chen, X.J, Dai, S.Y, Chen, Y.H. | | 登録日 | 2021-01-07 | | 公開日 | 2021-04-14 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Investigation of Covalent Warheads in the Design of 2-Aminopyrimidine-based FGFR4 Inhibitors.
Acs Med.Chem.Lett., 12, 2021
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8IQM
 | | Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival proteins | | 分子名称: | Bcl2 modifying factor, Induced myeloid leukemia cell differentiation protein Mcl-1 | | 著者 | Wang, H, Guo, M, Wei, H, Chen, Y. | | 登録日 | 2023-03-16 | | 公開日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.967 Å) | | 主引用文献 | Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins.
Comput Struct Biotechnol J, 21, 2023
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8IQK
 | | Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival proteins | | 分子名称: | Bcl-2-like protein 1, Bcl-2-modifying factor | | 著者 | Wang, H, Guo, M, Wei, H, Chen, Y. | | 登録日 | 2023-03-16 | | 公開日 | 2023-08-23 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.879 Å) | | 主引用文献 | Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins.
Comput Struct Biotechnol J, 21, 2023
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8IQL
 | | Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival proteins | | 分子名称: | Apoptosis regulator Bcl-2, Bcl-2-modifying factor | | 著者 | Wang, H, Guo, M, Wei, H, Chen, Y. | | 登録日 | 2023-03-16 | | 公開日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.9577 Å) | | 主引用文献 | Structural basis of the specificity and interaction mechanism of Bmf binding to pro-survival Bcl-2 family proteins.
Comput Struct Biotechnol J, 21, 2023
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4GP4
 | | Structure of Recombinant Cytochrome ba3 Oxidase mutant Y133F from Thermus thermophilus | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, COPPER (II) ION, Cytochrome c oxidase polypeptide 2A, ... | | 著者 | Li, Y, Chen, Y, Stout, C.D. | | 登録日 | 2012-08-20 | | 公開日 | 2013-01-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Ligand Access to the Active Site in Thermus thermophilusba(3) and Bovine Heart aa(3) Cytochrome Oxidases.
Biochemistry, 52, 2013
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3QPM
 | | Crystal structure of peroxiredoxin Prx4 from Pseudosciaena crocea | | 分子名称: | GLYCEROL, Peroxiredoxin | | 著者 | Lian, F.M, Teng, Y.B, Jiang, Y.L, He, Y.X, Chen, Y, Zhou, C.Z. | | 登録日 | 2011-02-14 | | 公開日 | 2012-02-22 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The N-terminal beta-sheet of peroxiredoxin Prx4 in the large yellow croaker Pseudosciaena crocea is critical for its peroxidase and anti-bacterial activities
To be Published
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4PAS
 | | Heterodimeric coiled-coil structure of human GABA(B) receptor | | 分子名称: | Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2 | | 著者 | Burmakina, S, Geng, Y, Chen, Y, Fan, Q.R. | | 登録日 | 2014-04-10 | | 公開日 | 2014-05-07 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | | 主引用文献 | Heterodimeric coiled-coil interactions of human GABAB receptor.
Proc.Natl.Acad.Sci.USA, 111, 2014
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3QWB
 | | Crystal structure of Saccharomyces cerevisiae Zeta-crystallin-like quinone oxidoreductase Zta1 complexed with NADPH | | 分子名称: | GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Probable quinone oxidoreductase | | 著者 | Guo, P.C, Ma, X.X, Bao, Z.Z, Chen, Y.X, Zhou, C.Z. | | 登録日 | 2011-02-28 | | 公開日 | 2012-02-08 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Structural insights into the cofactor-assisted substrate recognition of yeast quinone oxidoreductase Zta1
J.Struct.Biol., 176, 2011
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4GP8
 | | Structure of Recombinant Cytochrome ba3 Oxidase mutant Y133W+T231F from Thermus thermophilus | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, COPPER (II) ION, Cytochrome c oxidase polypeptide 2A, ... | | 著者 | Li, Y, Chen, Y, Stout, C.D. | | 登録日 | 2012-08-20 | | 公開日 | 2013-01-16 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Ligand Access to the Active Site in Thermus thermophilusba(3) and Bovine Heart aa(3) Cytochrome Oxidases.
Biochemistry, 52, 2013
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5WUC
 | | Structural basis for conductance through TRIC cation channels | | 分子名称: | SODIUM ION, Uncharacterized protein | | 著者 | Su, M, Gao, F, Mao, Y, Li, D.L, Guo, Y.Z, Wang, X.H, Bruni, R, Kloss, B, Hendrickson, W.A, Chen, Y.H, New York Consortium on Membrane Protein Structure (NYCOMPS) | | 登録日 | 2016-12-17 | | 公開日 | 2017-07-12 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Structural basis for conductance through TRIC cation channels.
Nat Commun, 8, 2017
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3HKS
 | | Crystal structure of eukaryotic translation initiation factor eIF-5A2 from Arabidopsis thaliana | | 分子名称: | 1,2-ETHANEDIOL, Eukaryotic translation initiation factor 5A-2 | | 著者 | Teng, Y.B, He, Y.X, Jiang, Y.L, Chen, Y.X, Zhou, C.Z. | | 登録日 | 2009-05-25 | | 公開日 | 2009-09-29 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal structure of Arabidopsis translation initiation factor eIF-5A2
Proteins, 77, 2009
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5WUF
 | | Structural basis for conductance through TRIC cation channels | | 分子名称: | CADMIUM ION, Putative membrane protein | | 著者 | Mao, Y, Gao, F, Su, M, Wang, X.H, Zeng, Y, Bruni, R, Kloss, B, Hendrickson, W.A, Chen, Y.H, New York Consortium on Membrane Protein Structure (NYCOMPS) | | 登録日 | 2016-12-17 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.401 Å) | | 主引用文献 | Structural basis for conductance through TRIC cation channels.
Nat Commun, 8, 2017
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5WUD
 | | Structural basis for conductance through TRIC cation channels | | 分子名称: | MAGNESIUM ION, Uncharacterized protein | | 著者 | Su, M, Gao, F, Mao, Y, Li, D.L, Guo, Y.Z, Wang, X.H, Bruni, R, Kloss, B, Hendrickson, W.A, Chen, Y.H, New York Consortium on Membrane Protein Structure (NYCOMPS) | | 登録日 | 2016-12-17 | | 公開日 | 2017-06-21 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis for conductance through TRIC cation channels.
Nat Commun, 8, 2017
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7XUZ
 | | Crystal structure of a HDAC4-MEF2A-DNA ternary complex | | 分子名称: | DNA (5'-D(*TP*CP*TP*TP*AP*TP*AP*AP*AP*TP*AP*GP*T)-3'), DNA (5'-D(P*AP*CP*TP*AP*TP*TP*TP*AP*TP*AP*A)-3'), Histone deacetylase 4, ... | | 著者 | Dai, S.Y, Guo, L, Dey, R, Guo, M, Bates, D, Cayford, J, Chen, X.J, Wei, X.D, Chen, L, Chen, Y.H. | | 登録日 | 2022-05-20 | | 公開日 | 2023-11-29 | | 最終更新日 | 2024-06-12 | | 実験手法 | X-RAY DIFFRACTION (3.591 Å) | | 主引用文献 | Structural insights into the HDAC4-MEF2A-DNA complex and its implication in long-range transcriptional regulation.
Nucleic Acids Res., 52, 2024
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7F3M
 | | Crystal structure of FGFR4 kinase domain with PRN1371 | | 分子名称: | 6-[2,6-bis(chloranyl)-3,5-dimethoxy-phenyl]-2-(methylamino)-8-[3-(4-prop-2-enoylpiperazin-1-yl)propyl]pyrido[2,3-d]pyrimidin-7-one, Fibroblast growth factor receptor 4, SULFATE ION | | 著者 | Chen, X.J, Qu, L.Z, Dai, S.Y, Wei, H.D, Chen, Y.H. | | 登録日 | 2021-06-16 | | 公開日 | 2022-01-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.289 Å) | | 主引用文献 | Structural insights into the potency and selectivity of covalent pan-FGFR inhibitors
Commun Chem, 5, 2022
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5WUE
 | | Structural basis for conductance through TRIC cation channels | | 分子名称: | SULFATE ION, Uncharacterized protein | | 著者 | Su, M, Gao, F, Mao, Y, Li, D.L, Guo, Y.Z, Wang, X.H, Bruni, R, Kloss, B, Hendrickson, W.A, Chen, Y.H, New York Consortium on Membrane Protein Structure (NYCOMPS) | | 登録日 | 2016-12-17 | | 公開日 | 2017-06-21 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for conductance through TRIC cation channels.
Nat Commun, 8, 2017
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