3BVD
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![BU of 3bvd by Molmil](/molmil-images/mine/3bvd) | Structure of Surface-engineered Cytochrome ba3 Oxidase from Thermus thermophilus under Xenon Pressure, 100psi 5min | 分子名称: | COPPER (II) ION, Cytochrome c oxidase polypeptide 2A, Cytochrome c oxidase subunit 1, ... | 著者 | Luna, V.M, Chen, Y, Fee, J.A, Stout, C.D. | 登録日 | 2008-01-07 | 公開日 | 2008-05-20 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.37 Å) | 主引用文献 | Crystallographic Studies of Xe and Kr Binding within the Large Internal Cavity of Cytochrome ba3 from Thermus thermophilus: Structural Analysis and Role of Oxygen Transport Channels in the Heme-Cu Oxidases. Biochemistry, 47, 2008
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8KH6
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![BU of 8kh6 by Molmil](/molmil-images/mine/8kh6) | Crystal structure of FGFR4 kinase domain with 8r | 分子名称: | 1,2-ETHANEDIOL, 1-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-3-[5-bromanyl-6-(hydroxymethyl)-3-methoxy-pyridin-2-yl]urea, Fibroblast growth factor receptor 4, ... | 著者 | Lin, Q.M, Chen, X.J, Chen, Y.H. | 登録日 | 2023-08-21 | 公開日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity. J.Med.Chem., 67, 2024
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8KH7
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![BU of 8kh7 by Molmil](/molmil-images/mine/8kh7) | Crystal structure of FGFR4 kinase domain with 8zc | 分子名称: | 1,2-ETHANEDIOL, 1-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-3-[6-methanoyl-5-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3-(2-morpholin-4-ylethoxy)pyridin-2-yl]urea, Fibroblast growth factor receptor 4, ... | 著者 | Lin, Q.M, Chen, X.J, Chen, Y.H. | 登録日 | 2023-08-21 | 公開日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity. J.Med.Chem., 67, 2024
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8KH9
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![BU of 8kh9 by Molmil](/molmil-images/mine/8kh9) | Crystal structure of FGFR4(V550M) kinase domain with 8z | 分子名称: | 1,2-ETHANEDIOL, 1-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-3-[6-methanoyl-5-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3-(2-morpholin-4-ylethoxy)pyridin-2-yl]urea, Fibroblast growth factor receptor 4, ... | 著者 | Lin, Q.M, Chen, X.J, Chen, Y.H. | 登録日 | 2023-08-21 | 公開日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity. J.Med.Chem., 67, 2024
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8KH8
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![BU of 8kh8 by Molmil](/molmil-images/mine/8kh8) | Crystal structure of FGFR4(V550L) kinase domain with 8z | 分子名称: | 1,2-ETHANEDIOL, 1-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-3-[6-methanoyl-5-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3-(2-morpholin-4-ylethoxy)pyridin-2-yl]urea, Fibroblast growth factor receptor 4, ... | 著者 | Lin, Q.M, Chen, X.J, Chen, Y.H. | 登録日 | 2023-08-21 | 公開日 | 2024-07-31 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity. J.Med.Chem., 67, 2024
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6A3N
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![BU of 6a3n by Molmil](/molmil-images/mine/6a3n) | Crystal structure of the PDE9 catalytic domain in complex with inhibitor 2 | 分子名称: | 1-cyclopentyl-6-({(2R)-1-[(3S)-3-fluoropyrrolidin-1-yl]-1-oxopropan-2-yl}amino)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A, MAGNESIUM ION, ... | 著者 | Wu, Y.N, Zhou, Q, Chen, Y.P, Luo, H.B. | 登録日 | 2018-06-15 | 公開日 | 2019-04-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of Potent, Selective, and Orally Bioavailable Inhibitors against Phosphodiesterase-9, a Novel Target for the Treatment of Vascular Dementia. J. Med. Chem., 62, 2019
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3NJ5
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5XFF
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8IOD
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![BU of 8iod by Molmil](/molmil-images/mine/8iod) | Cryo-EM structure of the PG-901-bound human melanocortin receptor 5 (MC5R)-Gs complex | 分子名称: | CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,HiBiT, ... | 著者 | Feng, W.B, Zhou, Q.T, Chen, X.Y, Dai, A.T, Cai, X.Q, Liu, X, Zhao, F.H, Chen, Y, Ye, C.Y, Xu, Y.N, Cong, Z.T, Li, H, Lin, S, Yang, D.H, Wang, M.W. | 登録日 | 2023-03-10 | 公開日 | 2023-09-20 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (2.59 Å) | 主引用文献 | Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors. Cell Discov, 9, 2023
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8INR
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![BU of 8inr by Molmil](/molmil-images/mine/8inr) | Cryo-EM structure of the alpha-MSH-bound human melanocortin receptor 5 (MC5R)-Gs complex | 分子名称: | CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,HiBiT, ... | 著者 | Feng, W.B, Zhou, Q.T, Chen, X.Y, Dai, A.T, Cai, X.Q, Liu, X, Zhao, F.H, Chen, Y, Ye, C.Y, Xu, Y.N, Cong, Z.T, Li, H, Lin, S, Yang, D.H, Wang, M.W. | 登録日 | 2023-03-10 | 公開日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (2.73 Å) | 主引用文献 | Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors. Cell Discov, 9, 2023
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8IOC
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![BU of 8ioc by Molmil](/molmil-images/mine/8ioc) | Cryo-EM structure of the gamma-MSH-bound human melanocortin receptor 3 (MC3R)-Gs complex | 分子名称: | CALCIUM ION, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,HiBiT, ... | 著者 | Feng, W.B, Zhou, Q.T, Chen, X.Y, Dai, A.T, Cai, X.Q, Liu, X, Zhao, F.H, Chen, Y, Ye, C.Y, Xu, Y.N, Cong, Z.T, Li, H, Lin, S. | 登録日 | 2023-03-10 | 公開日 | 2023-09-20 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors. Cell Discov, 9, 2023
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8D4P
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6LQZ
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![BU of 6lqz by Molmil](/molmil-images/mine/6lqz) | Solution structure of Taf14ET-Sth1EBMC | 分子名称: | Nuclear protein STH1/NPS1, Transcription initiation factor TFIID subunit 14 | 著者 | Wu, B, Chen, G, Chen, Y. | 登録日 | 2020-01-15 | 公開日 | 2020-08-05 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Taf14 recognizes a common motif in transcriptional machineries and facilitates their clustering by phase separation. Nat Commun, 11, 2020
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7KX5
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![BU of 7kx5 by Molmil](/molmil-images/mine/7kx5) | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with noncovalent inhibitor Jun8-76-3A | 分子名称: | 3C-like proteinase, GLYCEROL, N-([1,1'-biphenyl]-4-yl)-N-[(1R)-2-oxo-2-{[(1S)-1-phenylethyl]amino}-1-(pyridin-3-yl)ethyl]furan-2-carboxamide | 著者 | Sacco, M, Wang, J, Chen, Y. | 登録日 | 2020-12-03 | 公開日 | 2020-12-16 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity. J.Am.Chem.Soc., 143, 2021
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6JPJ
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![BU of 6jpj by Molmil](/molmil-images/mine/6jpj) | Crystal structure of FGF401 in complex of FGFR4 | 分子名称: | Fibroblast growth factor receptor 4, N-[5-cyano-4-(2-methoxyethylamino)pyridin-2-yl]-7-methanoyl-6-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3,4-dihydro-2H-1,8-naphthyridine-1-carboxamide, SULFATE ION | 著者 | Zhou, Z, Chen, X, Chen, Y. | 登録日 | 2019-03-27 | 公開日 | 2019-05-15 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.638 Å) | 主引用文献 | Characterization of FGF401 as a reversible covalent inhibitor of fibroblast growth factor receptor 4. Chem.Commun.(Camb.), 55, 2019
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3B61
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8JX7
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![BU of 8jx7 by Molmil](/molmil-images/mine/8jx7) | Cryo-EM structure of human ABC transporter ABCC2 | 分子名称: | ATP-binding cassette sub-family C member 2 | 著者 | Mao, Y.X, Chen, Z.P, Wang, L, Hou, W.T, Chen, Y.X, Zhou, C.Z. | 登録日 | 2023-06-30 | 公開日 | 2024-01-03 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain. Nat Commun, 15, 2024
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7K99
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![BU of 7k99 by Molmil](/molmil-images/mine/7k99) | Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor 19 | 分子名称: | (hydroxy{(1S)-1-(methylsulfanyl)-2-[5-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)-1H-benzotriazol-1-yl]ethyl}amino)methanol, GLYCEROL, SULFATE ION, ... | 著者 | Sacco, M, Chen, Y. | 登録日 | 2020-09-28 | 公開日 | 2020-11-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay. Bioorg.Med.Chem., 28, 2020
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8HGR
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![BU of 8hgr by Molmil](/molmil-images/mine/8hgr) | The apo-flavodoxin monomer from Synechococcus elongatus PCC 7942 | 分子名称: | CHLORIDE ION, Flavodoxin, MAGNESIUM ION | 著者 | Liu, S.W, Chen, Y.Y, Gong, Y, Cao, P. | 登録日 | 2022-11-15 | 公開日 | 2022-12-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | A dimer-monomer transition captured by the crystal structures of cyanobacterial apo flavodoxin. Biochem.Biophys.Res.Commun., 639, 2022
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8HGQ
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![BU of 8hgq by Molmil](/molmil-images/mine/8hgq) | The apo-flavodoxin dimer from Synechococcus elongatus PCC 7942 | 分子名称: | Flavodoxin, PHOSPHATE ION | 著者 | Liu, S.W, Chen, Y.Y, Gong, Y, Cao, P. | 登録日 | 2022-11-15 | 公開日 | 2022-12-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | A dimer-monomer transition captured by the crystal structures of cyanobacterial apo flavodoxin. Biochem.Biophys.Res.Commun., 639, 2022
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6NEB
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![BU of 6neb by Molmil](/molmil-images/mine/6neb) | MYC Promoter G-Quadruplex with 1:6:1 loop length | 分子名称: | DNA (27-MER) | 著者 | Dickerhoff, J, Onel, B, Chen, L, Chen, Y, Yang, D. | 登録日 | 2018-12-17 | 公開日 | 2019-02-13 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution Structure of a MYC Promoter G-Quadruplex with 1:6:1 Loop Length. Acs Omega, 4, 2019
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8HGW
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8HGV
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7K9A
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![BU of 7k9a by Molmil](/molmil-images/mine/7k9a) | Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor | 分子名称: | DIMETHYL SULFOXIDE, GLYCEROL, N-hydroxy-N-[(1R)-2-{5-[(4-{[2-(hydroxymethyl)-1H-imidazol-1-yl]methyl}phenyl)ethynyl]-1H-benzotriazol-1-yl}-1-(methylsulfanyl)ethyl]formamide, ... | 著者 | Sacco, M, Chen, Y. | 登録日 | 2020-09-29 | 公開日 | 2020-11-25 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay. Bioorg.Med.Chem., 28, 2020
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8HBM
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