7K99
Crystal Structure of P. aeruginosa LpxC with N-Hydroxyformamide inhibitor 19
Summary for 7K99
Entry DOI | 10.2210/pdb7k99/pdb |
Descriptor | UDP-3-O-acyl-N-acetylglucosamine deacetylase, GLYCEROL, (hydroxy{(1S)-1-(methylsulfanyl)-2-[5-({4-[(morpholin-4-yl)methyl]phenyl}ethynyl)-1H-benzotriazol-1-yl]ethyl}amino)methanol, ... (6 entities in total) |
Functional Keywords | lpxc, hydrolase |
Biological source | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
Total number of polymer chains | 2 |
Total formula weight | 69217.00 |
Authors | |
Primary citation | Furuya, T.,Shapiro, A.B.,Comita-Prevoir, J.,Kuenstner, E.J.,Zhang, J.,Ribe, S.D.,Chen, A.,Hines, D.,Moussa, S.H.,Carter, N.M.,Sylvester, M.A.,Romero, J.A.C.,Vega, C.V.,Sacco, M.D.,Chen, Y.,O'Donnell, J.P.,Durand-Reville, T.F.,Miller, A.A.,Tommasi, R.A. N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay. Bioorg.Med.Chem., 28:115826-115826, 2020 Cited by PubMed: 33160146DOI: 10.1016/j.bmc.2020.115826 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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