8KH8
Crystal structure of FGFR4(V550L) kinase domain with 8z
Summary for 8KH8
Entry DOI | 10.2210/pdb8kh8/pdb |
Descriptor | Fibroblast growth factor receptor 4, SULFATE ION, 1-[4-[(1~{R})-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-5-cyano-pyridin-2-yl]-3-[6-methanoyl-5-[(4-methyl-2-oxidanylidene-piperazin-1-yl)methyl]-3-(2-morpholin-4-ylethoxy)pyridin-2-yl]urea, ... (5 entities in total) |
Functional Keywords | fgfr4 kinase domain, transferase, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 35393.57 |
Authors | |
Primary citation | Yang, F.,Lin, Q.,Song, X.,Huang, H.,Chen, X.,Tan, J.,Li, Y.,Zhou, Y.,Tu, Z.,Du, H.,Zhang, Z.M.,Ortega, R.,Lin, X.,Patterson, A.V.,Smaill, J.B.,Chen, Y.,Lu, X. Discovery of 6-Formylpyridyl Urea Derivatives as Potent Reversible-Covalent Fibroblast Growth Factor Receptor 4 Inhibitors with Improved Anti-Hepatocellular Carcinoma Activity. J.Med.Chem., 67:2667-2689, 2024 Cited by PubMed: 38348819DOI: 10.1021/acs.jmedchem.3c01810 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.49 Å) |
Structure validation
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