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PDB: 689 件
8JGO
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Crystal structure of Deinococcus radiodurans exopolyphosphatase
分子名称: Exopolyphosphatase, MAGNESIUM ION, SULFATE ION
著者Zhao, Y, Dai, S.
登録日2023-05-21
公開日2024-05-15
最終更新日2024-07-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural Evolution of Bacterial Polyphosphate Degradation Enzyme for Phosphorus Cycling.
Adv Sci, 11, 2024
8BTI
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Notum Inhibitor ARUK3004556
分子名称: 1,2-ETHANEDIOL, 1-(4-chloranylindol-1-yl)-2-methoxy-ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhao, Y, Jones, E.Y, Fish, P.
登録日2022-11-28
公開日2022-12-14
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.31 Å)
主引用文献Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
8BT0
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Notum Inhibitor ARUK3005518
分子名称: (3~{a}~{S})-2,2-bis(fluoranyl)-3~{a},4-dihydro-3~{H}-pyrrolo[1,2-a]indol-1-one, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhao, Y, Jones, E.Y, Fish, P.
登録日2022-11-27
公開日2022-12-14
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
8BSZ
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Notum Inhibitor ARUK3005522
分子名称: (3~{a}~{R})-2,3,3~{a},4-tetrahydropyrrolo[1,2-a]indol-1-one, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhao, Y, Jones, E.Y, Fish, P.
登録日2022-11-27
公開日2022-12-14
最終更新日2023-06-28
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
8BTA
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Notum Inhibitor ARUK3004308
分子名称: 1,2-ETHANEDIOL, 1-(4-chloranyl-2,3-dihydroindol-1-yl)ethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhao, Y, Jones, E.Y, Fish, P.
登録日2022-11-28
公開日2022-12-14
最終更新日2023-06-28
実験手法X-RAY DIFFRACTION (1.34 Å)
主引用文献Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
8BTH
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Notum Inhibitor ARUK3004552
分子名称: 1,2-ETHANEDIOL, 1-(2,3-dihydroindol-1-yl)prop-2-en-1-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhao, Y, Jones, E.Y, Fish, P.
登録日2022-11-28
公開日2022-12-14
最終更新日2023-06-28
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
8BT8
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Notum Inhibitor ARUK3004048
分子名称: 1,2-ETHANEDIOL, 1-indol-1-ylethanone, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhao, Y, Jones, E.Y, Fish, P.
登録日2022-11-28
公開日2022-12-28
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (1.28 Å)
主引用文献Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity.
Eur.J.Med.Chem., 251, 2023
1VBT
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Structure of cyclophilin complexed with sulfur-substituted tetrapeptide AAPF
分子名称: CYCLOPHILIN A, SULFUR-SUBSTITUTED TETRAPEPTIDE
著者Zhao, Y, Chen, Y, Schutkowski, M, Fischer, G, Ke, H.
登録日1998-06-16
公開日1999-01-13
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Insight Into Conversion of Substrate to Inhibitor
To be Published
5JQ3
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BU of 5jq3 by Molmil
Crystal structure of Ebola glycoprotein
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein 1,Envelope glycoprotein 1,Envelope glycoprotein 1, Envelope glycoprotein 2, ...
著者Zhao, Y, Ren, J, Stuart, D.I.
登録日2016-05-04
公開日2016-06-29
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Toremifene interacts with and destabilizes the Ebola virus glycoprotein.
Nature, 535, 2016
5JQB
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Crystal structure of Ebola glycoprotein in complex with ibuprofen
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein 1,Envelope glycoprotein 1,Envelope glycoprotein 1, Envelope glycoprotein 2, ...
著者Zhao, Y, Ren, J, Stuart, D.I.
登録日2016-05-04
公開日2016-06-29
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Toremifene interacts with and destabilizes the Ebola virus glycoprotein.
Nature, 535, 2016
5K4F
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CAL PDZ mutant C319A with a peptide
分子名称: Golgi-associated PDZ and coiled-coil motif-containing protein, HPV18E6 peptide
著者Zhao, Y, Madden, D.R.
登録日2016-05-20
公開日2017-08-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.36 Å)
主引用文献CAL PDZ domain mutant with a peptide
To Be Published
5JQ7
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Crystal structure of Ebola glycoprotein in complex with toremifene
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, Envelope glycoprotein 1,Envelope glycoprotein 1,Envelope glycoprotein 1, ...
著者Zhao, Y, Ren, J, Stuart, D.I.
登録日2016-05-04
公開日2016-06-29
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Toremifene interacts with and destabilizes the Ebola virus glycoprotein.
Nature, 535, 2016
5KK2
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BU of 5kk2 by Molmil
Architecture of fully occupied GluA2 AMPA receptor - TARP complex elucidated by single particle cryo-electron microscopy
分子名称: Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit
著者Zhao, Y, Chen, S, Yoshioka, C, Baconguis, I, Gouaux, E.
登録日2016-06-20
公開日2016-07-06
最終更新日2024-10-23
実験手法ELECTRON MICROSCOPY (7.3 Å)
主引用文献Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM.
Nature, 536, 2016
4Q4F
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Crystal structure of LIMP-2 (space group C2)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-O-phosphono-beta-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhao, Y, Ren, J, Padilla-Parra, S, Fry, L.E, Stuart, D.I.
登録日2014-04-14
公開日2014-07-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Lysosome sorting of beta-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor.
Nat Commun, 5, 2014
4Q4B
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Crystal structure of LIMP-2 (space group C2221)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Lysosome membrane protein 2, ...
著者Zhao, Y, Ren, J, Padilla-Parra, S, Fry, L.E, Stuart, D.I.
登録日2014-04-14
公開日2014-07-30
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (2.82 Å)
主引用文献Lysosome sorting of beta-glucocerebrosidase by LIMP-2 is targeted by the mannose 6-phosphate receptor.
Nat Commun, 5, 2014
8YZ7
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BU of 8yz7 by Molmil
Crystal structure of DdrI, a CRP family protein from Deinococcus radiodurans
分子名称: POTASSIUM ION, Transcriptional regulator, FNR/CRP family
著者Zhao, Y, Wang, Y.
登録日2024-04-06
公開日2024-07-03
最終更新日2024-09-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献cAMP-independent DNA binding of the CRP family protein DdrI from Deinococcus radiodurans.
Mbio, 15, 2024
1ONS
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BU of 1ons by Molmil
Crystal structure of Escherichia coli heat shock protein YedU
分子名称: Chaperone protein hchA, ZINC ION
著者Zhao, Y, Fox, R.O.
登録日2003-02-28
公開日2004-01-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The crystal structure of Escherichia coli heat shock protein YedU reveals three potential catalytic active sites
Protein Sci., 12, 2003
1PTY
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BU of 1pty by Molmil
CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO PHOSPHOTYROSINE MOLECULES
分子名称: MAGNESIUM ION, O-PHOSPHOTYROSINE, PROTEIN TYROSINE PHOSPHATASE 1B
著者Zhao, Y, Puius, Y.A, Sullivan, M, Lawrence, D, Almo, S.C, Zhang, Z.-Y.
登録日1997-01-16
公開日1998-01-21
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design.
Proc.Natl.Acad.Sci.USA, 94, 1997
8S7C
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BU of 8s7c by Molmil
Ternary Complex of Cachd1, FZD5 and LRP6
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Frizzled-5, ...
著者Zhao, Y, Ren, J, Jones, E.Y.
登録日2024-02-29
公開日2024-04-24
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (4.7 Å)
主引用文献Cachd1 interacts with Wnt receptors and regulates neuronal asymmetry in the zebrafish brain.
Science, 384, 2024
7X79
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The crystal structure of human Calpain-1 protease core in complex with 14b
分子名称: CALCIUM ION, Calpain-1 catalytic subunit, HYDROSULFURIC ACID, ...
著者Zhao, Y, Zhao, J, Shao, M, Yang, H, Rao, Z.
登録日2022-03-09
公開日2023-06-14
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The crystal structure of human Calpain-1 protease core in complex with 14a
To Be Published
5DTO
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BU of 5dto by Molmil
Dengue virus full length NS5 complexed with viral Cap 0-RNA and SAH
分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, ACETATE ION, MAGNESIUM ION, ...
著者Zhao, Y, Soh, T.S, Lim, S.P, Chung, K.Y, Swaminathan, K, Vasudevan, S.G, Shi, P.-Y, Lescar, J, Luo, D.
登録日2015-09-18
公開日2015-11-25
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.603 Å)
主引用文献Molecular basis for specific viral RNA recognition and 2'-O-ribose methylation by the dengue virus nonstructural protein 5 (NS5)
Proc.Natl.Acad.Sci.USA, 112, 2015
5CYH
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CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE GLY-PRO
分子名称: CYCLOPHILIN A, GLYCINE, PROLINE
著者Zhao, Y, Ke, H.
登録日1996-02-27
公開日1996-07-11
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Mechanistic implication of crystal structures of the cyclophilin-dipeptide complexes.
Biochemistry, 35, 1996
1RMH
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BU of 1rmh by Molmil
RECOMBINANT CYCLOPHILIN A FROM HUMAN T CELL
分子名称: AAPF PEPTIDE SUBSTRATE, CYCLOPHILIN A
著者Zhao, Y, Ke, H.
登録日1995-07-31
公開日1996-10-14
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure implies that cyclophilin predominantly catalyzes the trans to cis isomerization.
Biochemistry, 35, 1996
2CYH
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CYCLOPHILIN A COMPLEXED WITH DIPEPTIDE ALA-PRO
分子名称: ALANINE, CYCLOPHILIN A, PROLINE
著者Zhao, Y, Ke, H.
登録日1996-02-27
公開日1996-07-11
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Mechanistic implication of crystal structures of the cyclophilin-dipeptide complexes.
Biochemistry, 35, 1996
2BDM
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Structure of Cytochrome P450 2B4 with Bound Bifonazole
分子名称: 1-[PHENYL-(4-PHENYLPHENYL)-METHYL]IMIDAZOLE, 5-CYCLOHEXYL-1-PENTYL-BETA-D-MALTOSIDE, Cytochrome P450 2B4, ...
著者Zhao, Y, White, M.A, Muralidhara, B.K, Sun, L, Halpert, J.R, Stout, C.D.
登録日2005-10-20
公開日2005-12-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure of microsomal cytochrome P450 2B4 complexed with the antifungal drug bifonazole: insight into P450 conformational plasticity and membrane interaction.
J.Biol.Chem., 281, 2006

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