8BT8

Notum Inhibitor ARUK3004048

Summary for 8BT8

Entry DOI	10.2210/pdb8bt8/pdb
Descriptor	Palmitoleoyl-protein carboxylesterase NOTUM, 2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ... (7 entities in total)
Functional Keywords	inhibitor notum, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	45026.53
Authors	Zhao, Y.,Jones, E.Y.,Fish, P. (deposition date: 2022-11-28, release date: 2022-12-28, Last modification date: 2023-07-19)
Primary citation	Atkinson, B.N.,Willis, N.J.,Zhao, Y.,Patel, C.,Frew, S.,Costelloe, K.,Magno, L.,Svensson, F.,Jones, E.Y.,Fish, P.V. Designed switch from covalent to non-covalent inhibitors of carboxylesterase Notum activity. Eur.J.Med.Chem., 251:115132-115132, 2023 Cited by PubMed: 36934521 DOI: 10.1016/j.ejmech.2023.115132 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.28 Å)

Structure validation