5JQB
Crystal structure of Ebola glycoprotein in complex with ibuprofen
Summary for 5JQB
Entry DOI | 10.2210/pdb5jqb/pdb |
Descriptor | Envelope glycoprotein 1,Envelope glycoprotein 1,Envelope glycoprotein 1, Envelope glycoprotein 2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total) |
Functional Keywords | ebola virus, filoviridae, envelope glycoprotein, protein inhibitor complex, ibuprofen, toremifene, viral protein |
Biological source | Ebola virus - Mayinga, Zaire, 1976 More |
Cellular location | GP2: Virion membrane ; Single-pass type I membrane protein . GP1: Virion membrane ; Peripheral membrane protein. GP2-delta: Secreted : Q05320 |
Total number of polymer chains | 2 |
Total formula weight | 57430.24 |
Authors | Zhao, Y.,Ren, J.,Stuart, D.I. (deposition date: 2016-05-04, release date: 2016-06-29, Last modification date: 2024-01-10) |
Primary citation | Zhao, Y.,Ren, J.,Harlos, K.,Jones, D.M.,Zeltina, A.,Bowden, T.A.,Padilla-Parra, S.,Fry, E.E.,Stuart, D.I. Toremifene interacts with and destabilizes the Ebola virus glycoprotein. Nature, 535:168-172, 2016 Cited by PubMed: 27362232DOI: 10.1038/nature18615 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.68 Å) |
Structure validation
Download full validation report