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PDB: 401 results

7QIG
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BU of 7qig by Molmil
Infectious mouse-adapted RML scrapie prion fibril purified from terminally-infected mouse brains
Descriptor: Major prion protein
Authors:Manka, S.W, Zhang, W, Wenborn, A, Betts, J, Joiner, S, Saibil, H.R, Collinge, J, Wadsworth, J.D.F.
Deposit date:2021-12-14
Release date:2022-07-27
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:2.7 angstrom cryo-EM structure of ex vivo RML prion fibrils.
Nat Commun, 13, 2022
6U9I
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BU of 6u9i by Molmil
Crystal structure of BvnE pinacolase from Penicillium brevicompactum
Descriptor: BvnE, DI(HYDROXYETHYL)ETHER, GLYCEROL
Authors:Ye, Y, Du, L, Zhang, X, Newmister, S.A, McCauley, M, Alegre-Requena, J.V, Zhang, W, Mu, S, Minami, A, Fraley, A.E, Adrover-Castellano, M.L, Carney, N, Shende, V.V, Oikawa, H, Kato, H, Tsukamoto, S, Paton, R.S, Williams, R.M, Sherman, D.H, Li, S.
Deposit date:2019-09-09
Release date:2020-09-09
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.777 Å)
Cite:Fungal-derived brevianamide assembly by a stereoselective semipinacolase.
Nat Catal, 3, 2020
6RV2
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BU of 6rv2 by Molmil
Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, DECYL-BETA-D-MALTOPYRANOSIDE, ...
Authors:Rodstrom, K.E.J, Pike, A.C.W, Zhang, W, Quigley, A, Speedman, D, Mukhopadhyay, S.M.M, Shrestha, L, Chalk, R, Venkaya, S, Bushell, S.R, Tessitore, A, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2019-05-30
Release date:2019-08-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:A lower X-gate in TASK channels traps inhibitors within the vestibule.
Nature, 582, 2020
6RV4
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Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 2341237
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, POTASSIUM ION, ...
Authors:Rodstrom, K.E.J, Pike, A.C.W, Zhang, W, Quigley, A, Speedman, D, Mukhopadhyay, S.M.M, Shrestha, L, Chalk, R, Venkaya, S, Bushell, S.R, Tessitore, A, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2019-05-30
Release date:2019-08-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A lower X-gate in TASK channels traps inhibitors within the vestibule.
Nature, 582, 2020
6RV3
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BU of 6rv3 by Molmil
Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 1000493
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, DECYL-BETA-D-MALTOPYRANOSIDE, ...
Authors:Rodstrom, K.E.J, Pike, A.C.W, Zhang, W, Quigley, A, Speedman, D, Mukhopadhyay, S.M.M, Shrestha, L, Chalk, R, Venkaya, S, Bushell, S.R, Tessitore, A, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2019-05-30
Release date:2019-08-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A lower X-gate in TASK channels traps inhibitors within the vestibule.
Nature, 582, 2020
6F89
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BU of 6f89 by Molmil
Structure of H234A/Y235A P.abyssi Sua5
Descriptor: BICARBONATE ION, THREONINE, Threonylcarbamoyl-AMP synthase
Authors:Pichard-Kostuch, A, Zhang, W, Liger, D, Daugeron, M.C, Letoquart, J, Li de la Sierra-Gallay, I, Forterre, P, Collinet, B, van Tilbeurgh, H, Basta, T.
Deposit date:2017-12-12
Release date:2018-04-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t6A tRNA modification.
RNA, 24, 2018
6F87
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BU of 6f87 by Molmil
Crystal structure of P. abyssi Sua5 complexed with L-threonine and PPi
Descriptor: PYROPHOSPHATE 2-, THREONINE, Threonylcarbamoyl-AMP synthase
Authors:Pichard-Kostuch, A, Zhang, W, Liger, D, Daugeron, M.C, Letoquart, J, Li de la Sierra-Gallay, I, Forterre, P, Collinet, B, van Tilbeurgh, H, Basta, T.
Deposit date:2017-12-12
Release date:2018-04-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t6A tRNA modification.
RNA, 24, 2018
6F8Y
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BU of 6f8y by Molmil
Crystal structure of P. abyssi Sua5 complexed with L-threonine
Descriptor: THREONINE, Threonylcarbamoyl-AMP synthase
Authors:Pichard-Kostuch, A, Zhang, W, Liger, D, Daugeron, M.C, Letoquart, J, Li de la Sierra-Gallay, I, Forterre, P, Collinet, B, van Tilbeurgh, H, Basta, T.
Deposit date:2017-12-13
Release date:2018-04-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t6A tRNA modification.
RNA, 24, 2018
6GX5
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BU of 6gx5 by Molmil
Narrow Pick Filament from Pick's disease brain
Descriptor: Microtubule-associated protein tau
Authors:Falcon, B, Zhang, W, Murzin, A.G, Murshudov, G, Garringer, H.J, Vidal, R, Crowther, R.A, Ghetti, B, Scheres, S.H.W, Goedert, M.
Deposit date:2018-06-26
Release date:2018-09-12
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structures of filaments from Pick's disease reveal a novel tau protein fold.
Nature, 561, 2018
8OR1
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BU of 8or1 by Molmil
Co-crystal strucutre of PD-L1 with low molecular weight inhibitor
Descriptor: 5-[[5-[[2-chloranyl-3-(2-fluorophenyl)phenyl]methoxy]-2-[(~{E})-2-hydroxyethyliminomethyl]phenoxy]methyl]pyridine-3-carbonitrile, Programmed cell death 1 ligand 1
Authors:Zhang, H, Zhou, S, Wu, C, Zhu, M, Yu, Q, Wang, X, Awadasseid, A, Plewka, J, Magiera-Mularz, K, Wu, Y, Zhang, W.
Deposit date:2023-04-12
Release date:2023-08-02
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4-(2,2'-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors.
J.Med.Chem., 66, 2023
6HOG
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BU of 6hog by Molmil
Structure of VPS34 LIR motif bound to GABARAP
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Phosphatidylinositol 3-kinase catalytic subunit type 3,Gamma-aminobutyric acid receptor-associated protein, ...
Authors:Mouilleron, S, Birgisdottir, A.B, Bhujbal, Z, Wirth, M, Sjottem, E, Evjen, G, Zhang, W, Lee, R, O'Reilly, N, Tooze, S, Lamark, T, Johansen, T.
Deposit date:2018-09-17
Release date:2019-02-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
Autophagy, 15, 2019
2Y2E
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BU of 2y2e by Molmil
crystal structure of AmpD grown at pH 5.5
Descriptor: 1,6-ANHYDRO-N-ACETYLMURAMYL-L-ALANINE AMIDASE AMPD, ZINC ION
Authors:Carrasco-Lopez, C, Rojas-Altuve, A, Zhang, W, Hesek, D, Lee, M, Barbe, S, Andre, I, Silva-Martin, N, Martinez-Ripoll, M, Mobashery, S, Hermoso, J.A.
Deposit date:2010-12-14
Release date:2011-07-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Bacterial Peptidoglycan Amidase Ampd and an Unprecedented Activation Mechanism.
J.Biol.Chem., 286, 2011
6HOK
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BU of 6hok by Molmil
Structure of Beclin1 LIR (S96E) motif bound to GABARAP
Descriptor: 1,2-ETHANEDIOL, Beclin-1,Gamma-aminobutyric acid receptor-associated protein
Authors:Mouilleron, S, Birgisdottir, A.B, Bhujbal, Z, Wirth, M, Sjottem, E, Evjen, G, Zhang, W, Lee, R, O'Reilly, N, Tooze, S, Lamark, T, Johansen, T.
Deposit date:2018-09-17
Release date:2019-02-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
Autophagy, 15, 2019
6HRE
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BU of 6hre by Molmil
Paired helical filament from sporadic Alzheimer's disease brain
Descriptor: Microtubule-associated protein tau
Authors:Falcon, B, Zhang, W, Schweighauser, M, Murzin, A.G, Vidal, R, Garringer, H.J, Ghetti, B, Scheres, S.H.W, Goedert, M.
Deposit date:2018-09-26
Release date:2018-10-10
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.
Acta Neuropathol., 136, 2018
6HOJ
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BU of 6hoj by Molmil
Structure of Beclin1 LIR motif bound to GABARAP
Descriptor: 1,2-ETHANEDIOL, Beclin-1,Gamma-aminobutyric acid receptor-associated protein, SULFATE ION
Authors:Mouilleron, S, Birgisdottir, A.B, Bhujbal, Z, Wirth, M, Sjottem, E, Evjen, G, Zhang, W, Lee, R, O'Reilly, N, Tooze, S, Lamark, T, Johansen, T.
Deposit date:2018-09-17
Release date:2019-02-27
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
Autophagy, 15, 2019
6HRF
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BU of 6hrf by Molmil
Straight filament from sporadic Alzheimer's disease brain
Descriptor: Microtubule-associated protein tau
Authors:Falcon, B, Zhang, W, Schweighauser, M, Murzin, A.G, Vidal, R, Garringer, H.J, Ghetti, B, Scheres, S.H.W, Goedert, M.
Deposit date:2018-09-26
Release date:2018-10-10
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.
Acta Neuropathol., 136, 2018
6HYO
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BU of 6hyo by Molmil
Structure of ULK1 LIR motif bound to GABARAP
Descriptor: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Mouilleron, S, Wirth, M, Zhang, W, O'Reilly, N, Tooze, S, Johansen, T, Razi, M, Nyoni, L, Joshi, D.
Deposit date:2018-10-22
Release date:2019-05-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.07 Å)
Cite:Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins.
Nat Commun, 10, 2019
6HYN
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BU of 6hyn by Molmil
Structure of ATG13 LIR motif bound to GABARAP
Descriptor: Autophagy-related protein 13,Gamma-aminobutyric acid receptor-associated protein
Authors:Mouilleron, S, Wirth, M, Zhang, W, O'Reilly, N, Tooze, S, Johansen, T, Razi, M, Nyoni, L, Joshi, D.
Deposit date:2018-10-22
Release date:2019-05-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins.
Nat Commun, 10, 2019
2Y2C
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BU of 2y2c by Molmil
crystal structure of AmpD Apoenzyme
Descriptor: 1,6-ANHYDRO-N-ACETYLMURAMYL-L-ALANINE AMIDASE AMPD
Authors:Carrasco-Lopez, C, Rojas-Altuve, A, Zhang, W, Hesek, D, Lee, M, Barbe, S, Andre, I, Silva-Martin, N, Martinez-Ripoll, M, Mobashery, S, Hermoso, J.A.
Deposit date:2010-12-14
Release date:2011-07-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Crystal Structures of Bacterial Peptidoglycan Amidase Ampd and an Unprecedented Activation Mechanism.
J.Biol.Chem., 286, 2011
2Y28
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BU of 2y28 by Molmil
crystal structure of Se-Met AmpD derivative
Descriptor: 1,6-ANHYDRO-N-ACETYLMURAMYL-L-ALANINE AMIDASE AMPD, ZINC ION
Authors:Carrasco-Lopez, C, Rojas-Altuve, A, Zhang, W, Hesek, D, Lee, M, Barbe, S, Andre, I, Silva-Martin, N, Martinez-Ripoll, M, Mobashery, S, Hermoso, J.A.
Deposit date:2010-12-14
Release date:2011-07-20
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Bacterial Peptidoglycan Amidase Ampd and an Unprecedented Activation Mechanism.
J.Biol.Chem., 286, 2011
2Y2B
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BU of 2y2b by Molmil
crystal structure of AmpD in complex with reaction products
Descriptor: 1,6-ANHYDRO-N-ACETYLMURAMYL-L-ALANINE AMIDASE AMPD, 2-(2-ACETYLAMINO-4-HYDROXY-6,8-DIOXA-BICYCLO[3.2.1]OCT-3-YLOXY)-PROPIONIC ACID, L-ALA-GAMMA-D-GLU-MESO-DIAMINOPIMELIC ACID, ...
Authors:Carrasco-Lopez, C, Rojas-Altuve, A, Zhang, W, Hesek, D, Lee, M, Barbe, S, Andre, I, Silva-Martin, N, Martinez-Ripoll, M, Mobashery, S, Hermoso, J.A.
Deposit date:2010-12-14
Release date:2011-07-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of Bacterial Peptidoglycan Amidase Ampd and an Unprecedented Activation Mechanism.
J.Biol.Chem., 286, 2011
6HOL
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BU of 6hol by Molmil
Structure of ATG14 LIR motif bound to GABARAPL1
Descriptor: Beclin 1-associated autophagy-related key regulator, GLYCEROL, Gamma-aminobutyric acid receptor-associated protein-like 1, ...
Authors:Mouilleron, S, Birgisdottir, A.B, Bhujbal, Z, Wirth, M, Sjottem, E, Evjen, G, Zhang, W, Lee, R, O'Reilly, N, Tooze, S, Lamark, T, Johansen, T.
Deposit date:2018-09-17
Release date:2019-02-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
Autophagy, 15, 2019
6HYL
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BU of 6hyl by Molmil
Structure of PCM1 LIR motif bound to GABARAP
Descriptor: Pericentriolar material 1 protein,Gamma-aminobutyric acid receptor-associated protein
Authors:Mouilleron, S, Wirth, M, Zhang, W, O'Reilly, N, Tooze, S, Johansen, T, Razi, M, Nyoni, L, Joshi, D.
Deposit date:2018-10-22
Release date:2019-05-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.559 Å)
Cite:Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins.
Nat Commun, 10, 2019
6HOH
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BU of 6hoh by Molmil
Structure of VPS34 LIR motif (S249E) bound to GABARAP
Descriptor: Phosphatidylinositol 3-kinase catalytic subunit type 3,Gamma-aminobutyric acid receptor-associated protein, TRIETHYLENE GLYCOL
Authors:Mouilleron, S, Birgisdottir, A.B, Bhujbal, Z, Wirth, M, Sjottem, E, Evjen, G, Zhang, W, Lee, R, O'Reilly, N, Tooze, S, Lamark, T, Johansen, T.
Deposit date:2018-09-17
Release date:2019-02-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
Autophagy, 15, 2019
6HOI
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BU of 6hoi by Molmil
Structure of Beclin1 LIR motif bound to GABARAPL1
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, Beclin-1, ...
Authors:Mouilleron, S, Birgisdottir, A.B, Bhujbal, Z, Wirth, M, Sjottem, E, Evjen, G, Zhang, W, Lee, R, O'Reilly, N, Tooze, S, Lamark, T, Johansen, T.
Deposit date:2018-09-17
Release date:2019-02-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
Autophagy, 15, 2019

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