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PDB: 402 results

8TAR
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BU of 8tar by Molmil
APC/C-CDH1-UBE2C-Ubiquitin-CyclinB-NTD
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G.
Deposit date:2023-06-27
Release date:2023-09-27
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Nat.Struct.Mol.Biol., 30, 2023
8TAU
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BU of 8tau by Molmil
APC/C-CDH1-UBE2C-UBE2S-Ubiquitin-CyclinB
Descriptor: Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ...
Authors:Bodrug, T, Welsh, K.A, Bolhuis, D.L, Paulakonis, E, Martinez-Chacin, R.C, Liu, B, Pinkin, N, Bonacci, T, Cui, L, Xu, P, Roscow, O, Amann, S.J, Grishkovskaya, I, Emanuele, M.J, Harrison, J.S, Steimel, J.P, Hahn, K.M, Zhang, W, Zhong, E, Haselbach, D, Brown, N.G.
Deposit date:2023-06-27
Release date:2023-09-27
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Time-resolved cryo-EM (TR-EM) analysis of substrate polyubiquitination by the RING E3 anaphase-promoting complex/cyclosome (APC/C).
Nat.Struct.Mol.Biol., 30, 2023
3FHA
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BU of 3fha by Molmil
Structure of endo-beta-N-acetylglucosaminidase A
Descriptor: CALCIUM ION, Endo-beta-N-acetylglucosaminidase, GLYCEROL, ...
Authors:Yin, J, Li, L, Shaw, N, Li, Y, Song, J.K, Zhang, W, Xia, C, Zhang, R, Joachimiak, A, Zhang, H.C, Wang, L.X, Wang, P, Liu, Z.J.
Deposit date:2008-12-09
Release date:2009-04-28
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis and catalytic mechanism for the dual functional endo-beta-N-acetylglucosaminidase A.
Plos One, 4, 2009
3FHQ
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BU of 3fhq by Molmil
Structure of endo-beta-N-acetylglucosaminidase A
Descriptor: 3AR,5R,6S,7R,7AR-5-HYDROXYMETHYL-2-METHYL-5,6,7,7A-TETRAHYDRO-3AH-PYRANO[3,2-D]THIAZOLE-6,7-DIOL, Endo-beta-N-acetylglucosaminidase, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose
Authors:Jie, Y, Li, L, Shaw, N, Li, Y, Song, J, Zhang, W, Xia, C, Zhang, R, Joachimiak, A, Zhang, H.-C, Wang, L.-X, Wang, P, Liu, Z.-J.
Deposit date:2008-12-10
Release date:2009-05-05
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.452 Å)
Cite:Structural basis and catalytic mechanism for the dual functional endo-beta-N-acetylglucosaminidase A
Plos One, 4, 2009
6F87
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BU of 6f87 by Molmil
Crystal structure of P. abyssi Sua5 complexed with L-threonine and PPi
Descriptor: PYROPHOSPHATE 2-, THREONINE, Threonylcarbamoyl-AMP synthase
Authors:Pichard-Kostuch, A, Zhang, W, Liger, D, Daugeron, M.C, Letoquart, J, Li de la Sierra-Gallay, I, Forterre, P, Collinet, B, van Tilbeurgh, H, Basta, T.
Deposit date:2017-12-12
Release date:2018-04-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t6A tRNA modification.
RNA, 24, 2018
6F8Y
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BU of 6f8y by Molmil
Crystal structure of P. abyssi Sua5 complexed with L-threonine
Descriptor: THREONINE, Threonylcarbamoyl-AMP synthase
Authors:Pichard-Kostuch, A, Zhang, W, Liger, D, Daugeron, M.C, Letoquart, J, Li de la Sierra-Gallay, I, Forterre, P, Collinet, B, van Tilbeurgh, H, Basta, T.
Deposit date:2017-12-13
Release date:2018-04-25
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Structure-function analysis of Sua5 protein reveals novel functional motifs required for the biosynthesis of the universal t6A tRNA modification.
RNA, 24, 2018
6GX5
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BU of 6gx5 by Molmil
Narrow Pick Filament from Pick's disease brain
Descriptor: Microtubule-associated protein tau
Authors:Falcon, B, Zhang, W, Murzin, A.G, Murshudov, G, Garringer, H.J, Vidal, R, Crowther, R.A, Ghetti, B, Scheres, S.H.W, Goedert, M.
Deposit date:2018-06-26
Release date:2018-09-12
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structures of filaments from Pick's disease reveal a novel tau protein fold.
Nature, 561, 2018
6HOG
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BU of 6hog by Molmil
Structure of VPS34 LIR motif bound to GABARAP
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Phosphatidylinositol 3-kinase catalytic subunit type 3,Gamma-aminobutyric acid receptor-associated protein, ...
Authors:Mouilleron, S, Birgisdottir, A.B, Bhujbal, Z, Wirth, M, Sjottem, E, Evjen, G, Zhang, W, Lee, R, O'Reilly, N, Tooze, S, Lamark, T, Johansen, T.
Deposit date:2018-09-17
Release date:2019-02-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.26 Å)
Cite:Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
Autophagy, 15, 2019
6HOK
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BU of 6hok by Molmil
Structure of Beclin1 LIR (S96E) motif bound to GABARAP
Descriptor: 1,2-ETHANEDIOL, Beclin-1,Gamma-aminobutyric acid receptor-associated protein
Authors:Mouilleron, S, Birgisdottir, A.B, Bhujbal, Z, Wirth, M, Sjottem, E, Evjen, G, Zhang, W, Lee, R, O'Reilly, N, Tooze, S, Lamark, T, Johansen, T.
Deposit date:2018-09-17
Release date:2019-02-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
Autophagy, 15, 2019
6HRE
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BU of 6hre by Molmil
Paired helical filament from sporadic Alzheimer's disease brain
Descriptor: Microtubule-associated protein tau
Authors:Falcon, B, Zhang, W, Schweighauser, M, Murzin, A.G, Vidal, R, Garringer, H.J, Ghetti, B, Scheres, S.H.W, Goedert, M.
Deposit date:2018-09-26
Release date:2018-10-10
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Tau filaments from multiple cases of sporadic and inherited Alzheimer's disease adopt a common fold.
Acta Neuropathol., 136, 2018
6HYL
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BU of 6hyl by Molmil
Structure of PCM1 LIR motif bound to GABARAP
Descriptor: Pericentriolar material 1 protein,Gamma-aminobutyric acid receptor-associated protein
Authors:Mouilleron, S, Wirth, M, Zhang, W, O'Reilly, N, Tooze, S, Johansen, T, Razi, M, Nyoni, L, Joshi, D.
Deposit date:2018-10-22
Release date:2019-05-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.559 Å)
Cite:Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins.
Nat Commun, 10, 2019
6HOL
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BU of 6hol by Molmil
Structure of ATG14 LIR motif bound to GABARAPL1
Descriptor: Beclin 1-associated autophagy-related key regulator, GLYCEROL, Gamma-aminobutyric acid receptor-associated protein-like 1, ...
Authors:Mouilleron, S, Birgisdottir, A.B, Bhujbal, Z, Wirth, M, Sjottem, E, Evjen, G, Zhang, W, Lee, R, O'Reilly, N, Tooze, S, Lamark, T, Johansen, T.
Deposit date:2018-09-17
Release date:2019-02-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs.
Autophagy, 15, 2019
7M3Q
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BU of 7m3q by Molmil
Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV)
Descriptor: 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, CHLORIDE ION, ...
Authors:Chowdhury, A, Singer, A.U, Ogunjimi, A.A, Teyra, J, Zhang, W, Sicheri, F, Sidhu, S.S.
Deposit date:2021-03-18
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Smurf2 HECT Domain with a High Affinity Ubiquitin Variant (UbV)
To be published
7Q4M
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BU of 7q4m by Molmil
Type II beta-amyloid 42 Filaments from Human Brain
Descriptor: Amyloid-beta precursor protein, UNKNOWN ATOM OR ION
Authors:Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M.
Deposit date:2021-11-01
Release date:2021-11-24
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Cryo-EM structures of amyloid-beta 42 filaments from human brains.
Science, 375, 2022
7Q4B
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BU of 7q4b by Molmil
Type I beta-amyloid 42 Filaments from Human Brain
Descriptor: Amyloid-beta precursor protein, UNKNOWN ATOM OR ION
Authors:Yang, Y, Arseni, D, Zhang, W, Huang, M, Lovestam, S.K.A, Schweighauser, M, Kotecha, A, Murzin, A.G, Peak-Chew, S.Y, Macdonald, J, Lavenir, I, Garringer, H.J, Gelpi, E, Newell, K.L, Kovacs, G.G, Vidal, R, Ghetti, B, Falcon, B, Scheres, S.H.W, Goedert, M.
Deposit date:2021-10-30
Release date:2021-11-24
Last modified:2024-07-17
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Cryo-EM structures of amyloid-beta 42 filaments from human brains.
Science, 375, 2022
7QIG
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BU of 7qig by Molmil
Infectious mouse-adapted RML scrapie prion fibril purified from terminally-infected mouse brains
Descriptor: Major prion protein
Authors:Manka, S.W, Zhang, W, Wenborn, A, Betts, J, Joiner, S, Saibil, H.R, Collinge, J, Wadsworth, J.D.F.
Deposit date:2021-12-14
Release date:2022-07-27
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:2.7 angstrom cryo-EM structure of ex vivo RML prion fibrils.
Nat Commun, 13, 2022
5XKA
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BU of 5xka by Molmil
Crystal structure of M.tuberculosis PknI kinase domain
Descriptor: Serine/threonine-protein kinase PknI
Authors:Yan, Q, Jiang, D, Qian, L, Zhang, Q, Zhang, W, Zhou, W, Mi, K, Guddat, L, Yang, H, Rao, Z.
Deposit date:2017-05-06
Release date:2018-05-16
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.599 Å)
Cite:Structural Insight into the Activation of PknI Kinase from M. tuberculosis via Dimerization of the Extracellular Sensor Domain.
Structure, 25, 2017
6RV4
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BU of 6rv4 by Molmil
Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 2341237
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, POTASSIUM ION, ...
Authors:Rodstrom, K.E.J, Pike, A.C.W, Zhang, W, Quigley, A, Speedman, D, Mukhopadhyay, S.M.M, Shrestha, L, Chalk, R, Venkaya, S, Bushell, S.R, Tessitore, A, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2019-05-30
Release date:2019-08-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A lower X-gate in TASK channels traps inhibitors within the vestibule.
Nature, 582, 2020
6RV2
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BU of 6rv2 by Molmil
Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, DECYL-BETA-D-MALTOPYRANOSIDE, ...
Authors:Rodstrom, K.E.J, Pike, A.C.W, Zhang, W, Quigley, A, Speedman, D, Mukhopadhyay, S.M.M, Shrestha, L, Chalk, R, Venkaya, S, Bushell, S.R, Tessitore, A, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2019-05-30
Release date:2019-08-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3 Å)
Cite:A lower X-gate in TASK channels traps inhibitors within the vestibule.
Nature, 582, 2020
2Y2E
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BU of 2y2e by Molmil
crystal structure of AmpD grown at pH 5.5
Descriptor: 1,6-ANHYDRO-N-ACETYLMURAMYL-L-ALANINE AMIDASE AMPD, ZINC ION
Authors:Carrasco-Lopez, C, Rojas-Altuve, A, Zhang, W, Hesek, D, Lee, M, Barbe, S, Andre, I, Silva-Martin, N, Martinez-Ripoll, M, Mobashery, S, Hermoso, J.A.
Deposit date:2010-12-14
Release date:2011-07-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Bacterial Peptidoglycan Amidase Ampd and an Unprecedented Activation Mechanism.
J.Biol.Chem., 286, 2011
2Y2D
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BU of 2y2d by Molmil
crystal structure of AmpD holoenzyme
Descriptor: 1,6-ANHYDRO-N-ACETYLMURAMYL-L-ALANINE AMIDASE AMPD, ZINC ION
Authors:Carrasco-Lopez, C, Rojas-Altuve, A, Zhang, W, Hesek, D, Lee, M, Barbe, S, Andre, I, Silva-Martin, N, Martinez-Ripoll, M, Mobashery, S, Hermoso, J.A.
Deposit date:2010-12-14
Release date:2011-07-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Bacterial Peptidoglycan Amidase Ampd and an Unprecedented Activation Mechanism.
J.Biol.Chem., 286, 2011
2Y2C
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BU of 2y2c by Molmil
crystal structure of AmpD Apoenzyme
Descriptor: 1,6-ANHYDRO-N-ACETYLMURAMYL-L-ALANINE AMIDASE AMPD
Authors:Carrasco-Lopez, C, Rojas-Altuve, A, Zhang, W, Hesek, D, Lee, M, Barbe, S, Andre, I, Silva-Martin, N, Martinez-Ripoll, M, Mobashery, S, Hermoso, J.A.
Deposit date:2010-12-14
Release date:2011-07-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Crystal Structures of Bacterial Peptidoglycan Amidase Ampd and an Unprecedented Activation Mechanism.
J.Biol.Chem., 286, 2011
2Y2B
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BU of 2y2b by Molmil
crystal structure of AmpD in complex with reaction products
Descriptor: 1,6-ANHYDRO-N-ACETYLMURAMYL-L-ALANINE AMIDASE AMPD, 2-(2-ACETYLAMINO-4-HYDROXY-6,8-DIOXA-BICYCLO[3.2.1]OCT-3-YLOXY)-PROPIONIC ACID, L-ALA-GAMMA-D-GLU-MESO-DIAMINOPIMELIC ACID, ...
Authors:Carrasco-Lopez, C, Rojas-Altuve, A, Zhang, W, Hesek, D, Lee, M, Barbe, S, Andre, I, Silva-Martin, N, Martinez-Ripoll, M, Mobashery, S, Hermoso, J.A.
Deposit date:2010-12-14
Release date:2011-07-20
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of Bacterial Peptidoglycan Amidase Ampd and an Unprecedented Activation Mechanism.
J.Biol.Chem., 286, 2011
6RV3
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BU of 6rv3 by Molmil
Crystal structure of the human two pore domain potassium ion channel TASK-1 (K2P3.1) in a closed conformation with a bound inhibitor BAY 1000493
Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, DECYL-BETA-D-MALTOPYRANOSIDE, ...
Authors:Rodstrom, K.E.J, Pike, A.C.W, Zhang, W, Quigley, A, Speedman, D, Mukhopadhyay, S.M.M, Shrestha, L, Chalk, R, Venkaya, S, Bushell, S.R, Tessitore, A, Burgess-Brown, N, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Carpenter, E.P, Structural Genomics Consortium (SGC)
Deposit date:2019-05-30
Release date:2019-08-07
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A lower X-gate in TASK channels traps inhibitors within the vestibule.
Nature, 582, 2020
2Y28
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BU of 2y28 by Molmil
crystal structure of Se-Met AmpD derivative
Descriptor: 1,6-ANHYDRO-N-ACETYLMURAMYL-L-ALANINE AMIDASE AMPD, ZINC ION
Authors:Carrasco-Lopez, C, Rojas-Altuve, A, Zhang, W, Hesek, D, Lee, M, Barbe, S, Andre, I, Silva-Martin, N, Martinez-Ripoll, M, Mobashery, S, Hermoso, J.A.
Deposit date:2010-12-14
Release date:2011-07-20
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Bacterial Peptidoglycan Amidase Ampd and an Unprecedented Activation Mechanism.
J.Biol.Chem., 286, 2011

227561

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