6HOH

Structure of VPS34 LIR motif (S249E) bound to GABARAP

Summary for 6HOH

Entry DOI	10.2210/pdb6hoh/pdb
Descriptor	Phosphatidylinositol 3-kinase catalytic subunit type 3,Gamma-aminobutyric acid receptor-associated protein, TRIETHYLENE GLYCOL (3 entities in total)
Functional Keywords	autophagy, atg8, lir, signaling protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	61084.25
Authors	Mouilleron, S.,Birgisdottir, A.B.,Bhujbal, Z.,Wirth, M.,Sjottem, E.,Evjen, G.,Zhang, W.,Lee, R.,O'Reilly, N.,Tooze, S.,Lamark, T.,Johansen, T. (deposition date: 2018-09-17, release date: 2019-02-27, Last modification date: 2024-01-24)
Primary citation	Birgisdottir, A.B.,Mouilleron, S.,Bhujabal, Z.,Wirth, M.,Sjottem, E.,Evjen, G.,Zhang, W.,Lee, R.,O'Reilly, N.,Tooze, S.A.,Lamark, T.,Johansen, T. Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs. Autophagy, 15:1333-1355, 2019 Cited by PubMed: 30767700 DOI: 10.1080/15548627.2019.1581009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation