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6HOH

Structure of VPS34 LIR motif (S249E) bound to GABARAP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0000139cellular_componentGolgi membrane
A0000226biological_processmicrotubule cytoskeleton organization
A0000421cellular_componentautophagosome membrane
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005776cellular_componentautophagosome
A0005790cellular_componentsmooth endoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005874cellular_componentmicrotubule
A0005875cellular_componentmicrotubule associated complex
A0005886cellular_componentplasma membrane
A0005930cellular_componentaxoneme
A0006605biological_processprotein targeting
A0006914biological_processautophagy
A0006915biological_processapoptotic process
A0006995biological_processcellular response to nitrogen starvation
A0007268biological_processchemical synaptic transmission
A0008017molecular_functionmicrotubule binding
A0008429molecular_functionphosphatidylethanolamine binding
A0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
A0012505cellular_componentendomembrane system
A0015031biological_processprotein transport
A0015629cellular_componentactin cytoskeleton
A0016020cellular_componentmembrane
A0031410cellular_componentcytoplasmic vesicle
A0031625molecular_functionubiquitin protein ligase binding
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0035020biological_processregulation of Rac protein signal transduction
A0045202cellular_componentsynapse
A0048487molecular_functionbeta-tubulin binding
A0050811molecular_functionGABA receptor binding
A0097225cellular_componentsperm midpiece
A0097352biological_processautophagosome maturation
A1902524biological_processpositive regulation of protein K48-linked ubiquitination
B0000045biological_processautophagosome assembly
B0000139cellular_componentGolgi membrane
B0000226biological_processmicrotubule cytoskeleton organization
B0000421cellular_componentautophagosome membrane
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005776cellular_componentautophagosome
B0005790cellular_componentsmooth endoplasmic reticulum
B0005794cellular_componentGolgi apparatus
B0005829cellular_componentcytosol
B0005856cellular_componentcytoskeleton
B0005874cellular_componentmicrotubule
B0005875cellular_componentmicrotubule associated complex
B0005886cellular_componentplasma membrane
B0005930cellular_componentaxoneme
B0006605biological_processprotein targeting
B0006914biological_processautophagy
B0006915biological_processapoptotic process
B0006995biological_processcellular response to nitrogen starvation
B0007268biological_processchemical synaptic transmission
B0008017molecular_functionmicrotubule binding
B0008429molecular_functionphosphatidylethanolamine binding
B0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
B0012505cellular_componentendomembrane system
B0015031biological_processprotein transport
B0015629cellular_componentactin cytoskeleton
B0016020cellular_componentmembrane
B0031410cellular_componentcytoplasmic vesicle
B0031625molecular_functionubiquitin protein ligase binding
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0035020biological_processregulation of Rac protein signal transduction
B0045202cellular_componentsynapse
B0048487molecular_functionbeta-tubulin binding
B0050811molecular_functionGABA receptor binding
B0097225cellular_componentsperm midpiece
B0097352biological_processautophagosome maturation
B1902524biological_processpositive regulation of protein K48-linked ubiquitination
C0000045biological_processautophagosome assembly
C0000139cellular_componentGolgi membrane
C0000226biological_processmicrotubule cytoskeleton organization
C0000421cellular_componentautophagosome membrane
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005776cellular_componentautophagosome
C0005790cellular_componentsmooth endoplasmic reticulum
C0005794cellular_componentGolgi apparatus
C0005829cellular_componentcytosol
C0005856cellular_componentcytoskeleton
C0005874cellular_componentmicrotubule
C0005875cellular_componentmicrotubule associated complex
C0005886cellular_componentplasma membrane
C0005930cellular_componentaxoneme
C0006605biological_processprotein targeting
C0006914biological_processautophagy
C0006915biological_processapoptotic process
C0006995biological_processcellular response to nitrogen starvation
C0007268biological_processchemical synaptic transmission
C0008017molecular_functionmicrotubule binding
C0008429molecular_functionphosphatidylethanolamine binding
C0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
C0012505cellular_componentendomembrane system
C0015031biological_processprotein transport
C0015629cellular_componentactin cytoskeleton
C0016020cellular_componentmembrane
C0031410cellular_componentcytoplasmic vesicle
C0031625molecular_functionubiquitin protein ligase binding
C0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
C0035020biological_processregulation of Rac protein signal transduction
C0045202cellular_componentsynapse
C0048487molecular_functionbeta-tubulin binding
C0050811molecular_functionGABA receptor binding
C0097225cellular_componentsperm midpiece
C0097352biological_processautophagosome maturation
C1902524biological_processpositive regulation of protein K48-linked ubiquitination
D0000045biological_processautophagosome assembly
D0000139cellular_componentGolgi membrane
D0000226biological_processmicrotubule cytoskeleton organization
D0000421cellular_componentautophagosome membrane
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005764cellular_componentlysosome
D0005776cellular_componentautophagosome
D0005790cellular_componentsmooth endoplasmic reticulum
D0005794cellular_componentGolgi apparatus
D0005829cellular_componentcytosol
D0005856cellular_componentcytoskeleton
D0005874cellular_componentmicrotubule
D0005875cellular_componentmicrotubule associated complex
D0005886cellular_componentplasma membrane
D0005930cellular_componentaxoneme
D0006605biological_processprotein targeting
D0006914biological_processautophagy
D0006915biological_processapoptotic process
D0006995biological_processcellular response to nitrogen starvation
D0007268biological_processchemical synaptic transmission
D0008017molecular_functionmicrotubule binding
D0008429molecular_functionphosphatidylethanolamine binding
D0008625biological_processextrinsic apoptotic signaling pathway via death domain receptors
D0012505cellular_componentendomembrane system
D0015031biological_processprotein transport
D0015629cellular_componentactin cytoskeleton
D0016020cellular_componentmembrane
D0031410cellular_componentcytoplasmic vesicle
D0031625molecular_functionubiquitin protein ligase binding
D0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
D0035020biological_processregulation of Rac protein signal transduction
D0045202cellular_componentsynapse
D0048487molecular_functionbeta-tubulin binding
D0050811molecular_functionGABA receptor binding
D0097225cellular_componentsperm midpiece
D0097352biological_processautophagosome maturation
D1902524biological_processpositive regulation of protein K48-linked ubiquitination
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue PGE A 201
ChainResidue
ASER16
ALYS20
AHOH301
AHOH302
AHOH326

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:O88763
ChainResidueDetails
ASER-16
BSER-16
CSER-16
DSER-16

site_idSWS_FT_FI2
Number of Residues8
DetailsSITE: Interaction with LIR (LC3 nteracting Region) motif of ATG3 => ECO:0000269|PubMed:37252361, ECO:0007744|PDB:8AFI
ChainResidueDetails
AGLU17
AARG28
BGLU17
BARG28
CGLU17
CARG28
DGLU17
DARG28

222036

PDB entries from 2024-07-03

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