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PDB: 100 件

7YVF
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Omicron BA.4/5 SARS-CoV-2 S RBD in complex with TH027 Fab
分子名称: Spike glycoprotein, TH027 Fab heavy chain, TH027 Fab light chain
著者Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z.
登録日2022-08-19
公開日2023-06-28
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection.
Nat Commun, 14, 2023
7YVE
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Omicron BA.4/5 SARS-CoV-2 S in complex with TH027 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, TH027 Fab heavy chain, ...
著者Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z.
登録日2022-08-19
公開日2023-06-28
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection.
Nat Commun, 14, 2023
7YVH
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Omicron BA.4/5 SARS-CoV-2 S RBD in complex with TH132 Fab
分子名称: Spike glycoprotein, TH132 Fab heavy chain, TH132 Fab light chain
著者Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z.
登録日2022-08-19
公開日2023-06-28
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection.
Nat Commun, 14, 2023
7YVP
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Omicron BA.4/5 SARS-CoV-2 S in complex with TH272/281 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, TH272 Fab heavy chain, ...
著者Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z.
登録日2022-08-19
公開日2023-06-28
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection.
Nat Commun, 14, 2023
8IL3
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Cryo-EM structure of CD38 in complex with FTL004
分子名称: ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1, Heavy chain, Light chain
著者Yang, J, Wang, Y, Zhang, G.
登録日2023-03-01
公開日2023-03-29
実験手法ELECTRON MICROSCOPY (3.86 Å)
主引用文献FTL004, an anti-CD38 mAb with negligible RBC binding and enhanced pro-apoptotic activity, is a novel candidate for treatments of multiple myeloma and non-Hodgkin lymphoma.
J Hematol Oncol, 15, 2022
2FRH
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Crystal Structure of Sara, A Transcription Regulator From Staphylococcus Aureus
分子名称: CALCIUM ION, Staphylococcal accessory regulator A
著者Liu, Y, Manna, A.C, Ingavale, S, Cheung, A.L, Zhang, G.
登録日2006-01-19
公開日2006-01-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural and function analyses of the global regulatory protein SarA from Staphylococcus aureus.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2FNP
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Crystal structure of SarA
分子名称: Staphylococcal accessory regulator A
著者Liu, Y, Manna, A.C, Pan, C.H, Cheung, A.L, Zhang, G.
登録日2006-01-11
公開日2006-01-31
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural and function analyses of the global regulatory protein SarA from Staphylococcus aureus.
Proc.Natl.Acad.Sci.Usa, 103, 2006
5X8I
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Crystal structure of human CLK1 in complex with compound 25
分子名称: 5-[1-[(1S)-1-(4-fluorophenyl)ethyl]-[1,2,3]triazolo[4,5-c]quinolin-8-yl]-1,3-benzoxazole, Dual specificity protein kinase CLK1
著者Sun, Q.Z, Lin, G.F, Li, L.L, Jin, X.T, Huang, L.Y, Zhang, G, Wei, Y.Q, Lu, G.W, Yang, S.Y.
登録日2017-03-02
公開日2017-08-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (1.902 Å)
主引用文献Discovery of Potent and Selective Inhibitors of Cdc2-Like Kinase 1 (CLK1) as a New Class of Autophagy Inducers
J. Med. Chem., 60, 2017
5JFB
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Crystal structure of the scavenger receptor cysteine-rich domain 5 (SRCR5) from porcine CD163
分子名称: Scavenger receptor cysteine-rich type 1 protein M130
著者Ma, H, Jiang, L, Qiao, S, Zhang, G, Li, R.
登録日2016-04-19
公開日2017-03-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The Crystal Structure of the Fifth Scavenger Receptor Cysteine-Rich Domain of Porcine CD163 Reveals an Important Residue Involved in Porcine Reproductive and Respiratory Syndrome Virus Infection
J. Virol., 91, 2017
4N4X
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Crystal Structure of the MBP fused human SPLUNC1 (native form)
分子名称: DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, Maltose-binding periplasmic/Palate lung and nasal epithelium clone fusion protein
著者Ning, F, Wang, C, Niu, L, Chu, H.W, Zhang, G.
登録日2013-10-08
公開日2014-09-17
最終更新日2019-07-17
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Lipid ligands of human SPLUNC1
To be Published
2W7X
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Cellular inhibition of checkpoint kinase 2 and potentiation of cytotoxic drugs by novel Chk2 inhibitor PV1019
分子名称: 1,2-ETHANEDIOL, MAGNESIUM ION, N-[4-[(E)-N-carbamimidamido-C-methyl-carbonimidoyl]phenyl]-7-nitro-1H-indole-2-carboxamide, ...
著者Jobson, A.G, Lountos, G.T, Lorenzi, P.L, Llamas, J, Connelly, J, Tropea, J.E, Onda, A, Kondapaka, S, Zhang, G, Caplen, N.J, Caredellina, J.H, Monks, A, Self, C, Waugh, D.S, Shoemaker, R.H, Pommier, Y.
登録日2009-01-06
公開日2009-09-22
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Cellular Inhibition of Chk2 Kinase and Potentiation of Camptothecins and Radiation by the Novel Chk2 Inhibitor Pv1019.
J.Pharmacol.Exp.Ther., 331, 2009
6LM2
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BU of 6lm2 by Molmil
Crystal structure of Zinc binding protein ZinT from E. coli
分子名称: Metal-binding protein ZinT, ZINC ION
著者Xiang, L, Zhang, G, Zhou, J.
登録日2019-12-24
公開日2020-07-08
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.130084 Å)
主引用文献Crystal structure of Zinc binding protein ZinT from E. coli
To Be Published
6LPS
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Crystal structure of family 10 xylanase from Bacillus halodurans
分子名称: Beta-xylanase, MAGNESIUM ION
著者Xiang, L, Zhang, G, Zhou, J.
登録日2020-01-12
公開日2021-01-13
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.21357155 Å)
主引用文献Crystal structure of family 10 xylanase from Bacillus halodurans
To Be Published
2YIQ
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Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1322
分子名称: (E)-5-(1-(2-CARBAMIMIDOYLHYDRAZONO)ETHYL)-N-(1H-INDOL-6-YL)-1H-INDOLE-2-CARBOXAMIDE, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2
著者Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C, Zhang, G, Pommier, Y, Shoemaker, R.H, Waugh, D.S.
登録日2011-05-16
公開日2011-09-07
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献X-Ray Structures of Checkpoint Kinase 2 in Complex with Inhibitors that Target its Gatekeeper-Dependent Hydrophobic Pocket.
FEBS Lett., 585, 2011
2YIT
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Structural analysis of checkpoint kinase 2 in complex with PV1162, a novel inhibitor
分子名称: N-{4-[(1E)-N-carbamimidoylbutanehydrazonoyl]phenyl}-5-methoxy-1H-indole-2-carboxamide, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2
著者Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C, Zhang, G, Pommier, Y, Shoemaker, R.H, Waugh, D.S.
登録日2011-05-16
公開日2011-09-07
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献X-Ray Structures of Checkpoint Kinase 2 in Complex with Inhibitors that Target its Gatekeeper-Dependent Hydrophobic Pocket.
FEBS Lett., 585, 2011
2YIR
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Structural analysis of checkpoint kinase 2 in complex with inhibitor PV1352
分子名称: (E)-N-(5-(2-CARBAMIMIDOYLHYDRAZONO)-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)-7-NITRO-1H-INDOLE-2-CARBOXAMIDE, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2
著者Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C, Zhang, G, Pommier, Y, Shoemaker, R.H, Waugh, D.S.
登録日2011-05-16
公開日2011-09-07
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献X-Ray Structures of Checkpoint Kinase 2 in Complex with Inhibitors that Target its Gatekeeper-Dependent Hydrophobic Pocket.
FEBS Lett., 585, 2011
1RQL
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BU of 1rql by Molmil
Crystal Structure of Phosponoacetaldehyde Hydrolase Complexed with Magnesium and the Inhibitor Vinyl Sulfonate
分子名称: MAGNESIUM ION, Phosphonoacetaldehyde Hydrolase, VINYLSULPHONIC ACID
著者Morais, M.C, Zhang, G, Zhang, W, Olsen, D.B, Dunaway-Mariano, D, Allen, K.N.
登録日2003-12-05
公開日2004-04-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献X-ray crystallographic and site-directed mutagenesis analysis of the mechanism of Schiff-base formation in phosphonoacetaldehyde hydrolase catalysis
J.Biol.Chem., 279, 2004
2YCQ
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Crystal structure of checkpoint kinase 2 in complex with inhibitor PV1115
分子名称: N-{4-[(1E)-N-1H-IMIDAZOL-2-YLETHANEHYDRAZONOYL]PHENYL}-7-NITRO-1H-INDOLE-2-CARBOXAMIDE, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2
著者Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C.R, Pommier, Y, Shoemaker, R.H, Zhang, G, Waugh, D.S.
登録日2011-03-16
公開日2011-11-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy.
J.Struct.Biol., 176, 2011
2YCR
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Crystal structure of checkpoint kinase 2 in complex with inhibitor PV976
分子名称: 1,3-BIS{4-[(1E)-N-(4,5-DIHYDRO-1H-IMIDAZOL-2-YL)ETHANEHYDRAZONOYL]PHENYL}UREA, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2
著者Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C.R, Pommier, Y, Shoemaker, R.H, Zhang, G, Waugh, D.S.
登録日2011-03-16
公開日2011-11-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy.
J.Struct.Biol., 176, 2011
1RQN
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Phosphonoacetaldehyde hydrolase complexed with magnesium
分子名称: MAGNESIUM ION, Phosphonoacetaldehyde Hydrolase
著者Morais, M.C, Zhang, G, Zhang, W, Olsen, D.B, Dunaway-Mariano, D, Allen, K.N.
登録日2003-12-05
公開日2004-04-20
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献X-ray crystallographic and site-directed mutagenesis analysis of the mechanism of Schiff-base formation in phosphonoacetaldehyde hydrolase catalysis
J.Biol.Chem., 279, 2004
8GOU
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Omicron BA.4/5 SARS-CoV-2 S in complex with TH003 Fab
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, TH003 Fab heavy chain, ...
著者Guo, Y, Zhang, G, Liang, J, Liu, F, Rao, Z.
登録日2022-08-25
公開日2023-06-28
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Discovery and characterization of potent pan-variant SARS-CoV-2 neutralizing antibodies from individuals with Omicron breakthrough infection.
Nat Commun, 14, 2023
2YCF
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BU of 2ycf by Molmil
Crystal Structure of Checkpoint Kinase 2 in complex with Inhibitor PV1531
分子名称: (2E)-N-hydroxy-2-[1-(4-{[(4-{(1E)-1-[2-(N'-hydroxycarbamimidoyl)hydrazinylidene]ethyl}phenyl)carbamoyl]amino}phenyl)ethylidene]hydrazinecarboximidamide, MAGNESIUM ION, NITRATE ION, ...
著者Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C.R, Pommier, Y, Shoemaker, R.H, Zhang, G, Waugh, D.S.
登録日2011-03-14
公開日2011-11-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy.
J.Struct.Biol., 176, 2011
2YCS
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Crystal structure of checkpoint kinase 2 in complex with PV788
分子名称: N-{4-[(1E)-N-CARBAMIMIDOYLETHANEHYDRAZONOYL]PHENYL}-1H-INDOLE-3-CARBOXAMIDE, NITRATE ION, SERINE/THREONINE-PROTEIN KINASE CHK2
著者Lountos, G.T, Jobson, A.G, Tropea, J.E, Self, C.R, Pommier, Y, Shoemaker, R.H, Zhang, G, Waugh, D.S.
登録日2011-03-16
公開日2011-11-16
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural Characterization of Inhibitor Complexes with Checkpoint Kinase 2 (Chk2), a Drug Target for Cancer Therapy.
J.Struct.Biol., 176, 2011
2AMN
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Solution structure of Fowlicidin-1, a novel Cathelicidin antimicrobial peptide from chicken
分子名称: cathelicidin
著者Xiao, Y, Dai, H, Bommineni, Y.R, Prakash, O, Zhang, G.
登録日2005-08-09
公開日2006-07-18
最終更新日2024-05-08
実験手法SOLUTION NMR
主引用文献Structure-activity relationships of fowlicidin-1, a cathelicidin antimicrobial peptide in chicken.
Febs J., 273, 2006
7U13
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TMEM106B(120-254) singlet amyloid fibril from frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) type A (case 4)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B
著者Fitzpatrick, A.W.P, Stowell, M.H.B, Chang, A, Xiang, X, Wang, J, Lee, C, Arakhamia, T, Simjanoska, M, Wang, C, Carlomagno, Y, Zhang, G, Dhingra, S, Thierry, M, Perneel, J, Heeman, B, Forgrave, L.M, DeTure, M, DeMarco, M.L, Cook, C.N, Rademakers, R, Dickson, D, Petrucelli, L, Mackenzie, I.R.A.
登録日2022-02-19
公開日2022-03-23
最終更新日2022-04-27
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Homotypic fibrillization of TMEM106B across diverse neurodegenerative diseases.
Cell, 185, 2022

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