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PDB: 1650 件
1FBC
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CRYSTALLOGRAPHIC STUDIES OF THE CATALYTIC MECHANISM OF THE NEUTRAL FORM OF FRUCTOSE-1,6-BISPHOSPHATASE
分子名称: 2,5-anhydro-1,6-di-O-phosphono-D-glucitol, FRUCTOSE 1,6-BISPHOSPHATASE, MAGNESIUM ION
著者Zhang, Y, Liang, J.-Y, Huang, S, Ke, H, Lipscomb, W.N.
登録日1992-10-14
公開日1993-10-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase.
Biochemistry, 32, 1993
1FBF
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CRYSTALLOGRAPHIC STUDIES OF THE CATALYTIC MECHANISM OF THE NEUTRAL FORM OF FRUCTOSE-1,6-BISPHOSPHATASE
分子名称: 2,5-anhydro-1,6-di-O-phosphono-D-mannitol, FRUCTOSE 1,6-BISPHOSPHATASE, MAGNESIUM ION
著者Zhang, Y, Liang, J.-Y, Huang, S, Ke, H, Lipscomb, W.N.
登録日1992-10-16
公開日1993-10-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase.
Biochemistry, 32, 1993
7T1F
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Crystal structure of GDP-bound T50I mutant of human KRAS4B
分子名称: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas, MAGNESIUM ION
著者Zhang, Y, Zhang, C.
登録日2021-12-01
公開日2022-12-14
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural and functional analyses of a germline KRAS T50I mutation provide insights into Raf activation.
JCI Insight, 8, 2023
4XVC
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Crystal structure of an esterase from the bacterial hormone-sensitive lipase (HSL) family
分子名称: Esterase E40, phenylmethanesulfonic acid
著者Zhang, Y, Li, P.
登録日2015-01-27
公開日2015-03-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Interdomain Hydrophobic Interactions Modulate the Thermostability of Microbial Esterases from the Hormone-Sensitive Lipase Family.
J.Biol.Chem., 290, 2015
1FBD
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BU of 1fbd by Molmil
CRYSTALLOGRAPHIC STUDIES OF THE CATALYTIC MECHANISM OF THE NEUTRAL FORM OF FRUCTOSE-1,6-BISPHOSPHATASE
分子名称: 2,5-anhydro-1,6-di-O-phosphono-D-glucitol, FRUCTOSE 1,6-BISPHOSPHATASE, MANGANESE (II) ION
著者Zhang, Y, Liang, J.-Y, Huang, S, Ke, H, Lipscomb, W.N.
登録日1992-10-16
公開日1993-10-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase.
Biochemistry, 32, 1993
1FBH
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CRYSTALLOGRAPHIC STUDIES OF THE CATALYTIC MECHANISM OF THE NEUTRAL FORM OF FRUCTOSE-1,6-BISPHOSPHATASE
分子名称: 1,6-di-O-phosphono-alpha-D-fructofuranose, 1,6-di-O-phosphono-beta-D-fructofuranose, FRUCTOSE 1,6-BISPHOSPHATASE
著者Zhang, Y, Liang, J.-Y, Huang, S, Ke, H, Lipscomb, W.N.
登録日1992-10-16
公開日1993-10-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase.
Biochemistry, 32, 1993
1FBE
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CRYSTALLOGRAPHIC STUDIES OF THE CATALYTIC MECHANISM OF THE NEUTRAL FORM OF FRUCTOSE-1,6-BISPHOSPHATASE
分子名称: 2,5-anhydro-1,6-di-O-phosphono-D-glucitol, FRUCTOSE 1,6-BISPHOSPHATASE, ZINC ION
著者Zhang, Y, Liang, J.-Y, Huang, S, Ke, H, Lipscomb, W.N.
登録日1992-10-16
公開日1993-10-31
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Crystallographic studies of the catalytic mechanism of the neutral form of fructose-1,6-bisphosphatase.
Biochemistry, 32, 1993
5GSN
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Tmm in complex with methimazole
分子名称: 1-METHYL-1,3-DIHYDRO-2H-IMIDAZOLE-2-THIONE, FLAVIN-ADENINE DINUCLEOTIDE, Flavin-containing monooxygenase, ...
著者Zhang, Y.Z, Li, C.Y.
登録日2016-08-16
公開日2017-01-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.203 Å)
主引用文献Structural mechanism for bacterial oxidation of oceanic trimethylamine into trimethylamine N-oxide
Mol. Microbiol., 103, 2017
8UAI
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Crystal structure of hetero hexameric hazelnut allergen Cor a 9
分子名称: 11S globulin 1, 11S globulin 2, 11S globulin 3, ...
著者Zhang, Y.Z, Guo, F.
登録日2023-09-21
公開日2024-05-15
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Crystal structure of hetero hexameric 11S seed storage protein of hazelnut.
Plant Physiol Biochem., 210, 2024
6U3U
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Crystal Structure of Shiga Toxin 2K
分子名称: 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Shiga toxin 2K subunit A, ...
著者Zhang, Y.Z, He, X.H.
登録日2019-08-22
公開日2020-07-01
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.287 Å)
主引用文献Structural and Functional Characterization of Stx2k, a New Subtype of Shiga Toxin 2.
Microorganisms, 8, 2019
5LQ6
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BU of 5lq6 by Molmil
Salmonella effector SpvD - R161 variant
分子名称: SODIUM ION, Virulence protein vsdE
著者Zhang, Y, Grabe, G.J, Rolhion, N, Yang, Y, Holden, D.W, Hare, S.A.
登録日2016-08-16
公開日2016-11-02
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献The Salmonella Effector SpvD Is a Cysteine Hydrolase with a Serovar-specific Polymorphism Influencing Catalytic Activity, Suppression of Immune Responses, and Bacterial Virulence.
J. Biol. Chem., 291, 2016
7ST4
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BU of 7st4 by Molmil
Calcium-saturated jGCaMP8.410.80
分子名称: CALCIUM ION, GLYCEROL, L(+)-TARTARIC ACID, ...
著者Zhang, Y, Looger, L.L.
登録日2021-11-11
公開日2022-11-16
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Fast and sensitive GCaMP calcium indicators for imaging neural populations
Nature, 615, 2023
1FTA
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FRUCTOSE-1,6-BISPHOSPHATASE(D-FRUCTOSE-1,6-BISPHOSPHATE, 1-PHOSPHOHYDROLASE) (E.C.3.1.3.11) COMPLEXED WITH THE ALLOSTERIC INHIBITOR AMP
分子名称: ADENOSINE MONOPHOSPHATE, FRUCTOSE-1,6-BISPHOSPHATASE
著者Zhang, Y, Liang, J.-Y, Huang, S, Lipscomb, W.N.
登録日1993-09-27
公開日1995-11-14
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The allosteric site of human liver fructose-1,6-bisphosphatase. Analysis of six AMP site mutants based on the crystal structure.
J.Biol.Chem., 269, 1994
4RZZ
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BU of 4rzz by Molmil
Crystal structure of metallopeptidase-like dimethylsulphoniopropionate (DMSP) lyase RlDddP in complex with phosphate
分子名称: FE (III) ION, GLYCEROL, PHOSPHATE ION, ...
著者Zhang, Y, Wang, P.
登録日2014-12-27
公開日2015-08-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and molecular basis for the novel catalytic mechanism and evolution of DddP, an abundant peptidase-like bacterial Dimethylsulfoniopropionate lyase: a new enzyme from an old fold.
Mol.Microbiol., 98, 2015
8HIC
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BU of 8hic by Molmil
Crystal structure of UrtA from Prochlorococcus marinus str. MIT 9313 in complex with urea and calcium
分子名称: CALCIUM ION, Putative urea ABC transporter, substrate binding protein, ...
著者Zhang, Y.Z, Wang, P, Wang, C.
登録日2022-11-19
公開日2023-11-22
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural and molecular basis for urea recognition by Prochlorococcus.
J.Biol.Chem., 299, 2023
4S00
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BU of 4s00 by Molmil
Crystal structure of metallopeptidase-like dimethylsulphoniopropionate (DMSP) lyase RlDddP mutant Y366A in complex with acrylate
分子名称: ACRYLIC ACID, FE (III) ION, GLYCEROL, ...
著者Zhang, Y, Wang, P.
登録日2014-12-27
公開日2015-08-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献Structural and molecular basis for the novel catalytic mechanism and evolution of DddP, an abundant peptidase-like bacterial Dimethylsulfoniopropionate lyase: a new enzyme from an old fold.
Mol.Microbiol., 98, 2015
4RZY
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Crystal structure of metallopeptidase-like dimethylsulphoniopropionate (DMSP) lyase RlDddP in complex with MES
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, FE (III) ION, Peptidase M24
著者Zhang, Y, Wang, P.
登録日2014-12-26
公開日2015-08-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.949 Å)
主引用文献Structural and molecular basis for the novel catalytic mechanism and evolution of DddP, an abundant peptidase-like bacterial Dimethylsulfoniopropionate lyase: a new enzyme from an old fold.
Mol.Microbiol., 98, 2015
4S01
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Crystal structure of metallopeptidase-like dimethylsulphoniopropionate (DMSP) lyase RlDddP mutant D377N in complex with acrylate
分子名称: ACRYLIC ACID, FE (III) ION, GLYCEROL, ...
著者Zhang, Y, Wang, P.
登録日2014-12-27
公開日2015-08-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and molecular basis for the novel catalytic mechanism and evolution of DddP, an abundant peptidase-like bacterial Dimethylsulfoniopropionate lyase: a new enzyme from an old fold.
Mol.Microbiol., 98, 2015
6XNX
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Structure of RAG1 (R848M/E649V)-RAG2-DNA Strand Transfer Complex (Dynamic-Form)
分子名称: 12RSS integration strand DNA (55-MER), 12RSS signal top strand DNA (34-MER), 23RSS integration strand DNA (66-MER), ...
著者Zhang, Y, Corbett, E, Wu, S, Schatz, D.G.
登録日2020-07-05
公開日2020-08-26
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structural basis for the activation and suppression of transposition during evolution of the RAG recombinase.
Embo J., 39, 2020
4XV9
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BU of 4xv9 by Molmil
B-Raf Kinase domain in complex with PLX5568
分子名称: N-{3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl}-4-(trifluoromethyl)benzenesulfonamide, SULFATE ION, Serine/threonine-protein kinase B-raf
著者zhang, Y, zhang, c, wang, w.
登録日2015-01-26
公開日2015-10-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献RAF inhibitors that evade paradoxical MAPK pathway activation.
Nature, 526, 2015
4XZ6
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TmoX in complex with TMAO
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, GLYCEROL, ...
著者Zhang, Y.Z, Li, C.Y.
登録日2015-02-04
公開日2015-08-19
最終更新日2015-10-28
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Mechanistic Insight into Trimethylamine N-Oxide Recognition by the Marine Bacterium Ruegeria pomeroyi DSS-3
J.Bacteriol., 197, 2015
6N33
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Crystal structure of fms kinase domain with a small molecular inhibitor, PLX5622
分子名称: 6-fluoro-N-[(5-fluoro-2-methoxypyridin-3-yl)methyl]-5-[(5-methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl]pyridin-2-amine, Macrophage colony-stimulating factor 1 receptor
著者Zhang, Y.
登録日2018-11-14
公開日2019-09-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model.
Nat Commun, 10, 2019
8H97
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GH86 agarase Aga86A_Wa
分子名称: Beta-agarase, CALCIUM ION, HEXAETHYLENE GLYCOL
著者Zhang, Y.Y, Dong, S, Feng, Y.G, Chang, Y.G.
登録日2022-10-25
公開日2023-02-22
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.194 Å)
主引用文献Structural characterization on a beta-agarase Aga86A_Wa from Wenyingzhuangia aestuarii reveals the prevalent methyl-galactose accommodation capacity of GH86 enzymes at subsite -1.
Carbohydr Polym, 306, 2023
8H91
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Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with nanobody N19
分子名称: Spike protein S1, nanobody
著者Zhang, Y.T, Li, J, Zhang, J.
登録日2022-10-24
公開日2023-11-01
実験手法X-RAY DIFFRACTION (3.07 Å)
主引用文献Crystal structure of SARS-CoV-2 spike receptor-binding domain in complex with nanobody N19
To Be Published
5LS6
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Structure of Human Polycomb Repressive Complex 2 (PRC2) with inhibitor
分子名称: 1-[(1~{R})-1-[1-[2,2-bis(fluoranyl)propyl]piperidin-4-yl]ethyl]-~{N}-[(4-methoxy-6-methyl-2-oxidanylidene-3~{H}-pyridin-3-yl)methyl]-2-methyl-indole-3-carboxamide, Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2,Histone-lysine N-methyltransferase EZH2, Jarid2 K116me3, ...
著者Zhang, Y, Justin, N, Chen, S, Wilson, J, Gamblin, S.
登録日2016-08-22
公開日2017-02-22
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.47 Å)
主引用文献Identification of (R)-N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205), a Potent and Selective Inhibitor of Histone Methyltransferase EZH2, Suitable for Phase I Clinical Trials for B-Cell Lymphomas.
J. Med. Chem., 59, 2016

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件を2024-07-17に公開中

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